{"id":7635,"date":"2018-05-29T00:00:00","date_gmt":"2018-05-28T22:00:00","guid":{"rendered":"https:\/\/idibell.cat\/blog\/2018\/05\/29\/nou-biomarcador-no-invasiu-de-diagnostic-i-pronostic-en-esterilitat-masculina\/"},"modified":"2020-05-13T19:46:24","modified_gmt":"2020-05-13T17:46:24","slug":"nou-biomarcador-no-invasiu-de-diagnostic-i-pronostic-en-esterilitat-masculina","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2018\/05\/nou-biomarcador-no-invasiu-de-diagnostic-i-pronostic-en-esterilitat-masculina\/","title":{"rendered":"Nou biomarcador no invasiu de diagn\u00f2stic i pron\u00f2stic en esterilitat masculina"},"content":{"rendered":"<p>Investigadors del grup de Gen\u00e8tica Molecular Humana de l&#8217;Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), liderats per la Dra Sara Larriba, han identificat un nou biomarcador no invasiu de la pres\u00e8ncia d&#8217;espermatozoides en els testicles d&#8217;homes azoosp\u00e8rmics, que representen el 10% de els casos d&#8217;esterilitat masculina. El treball, publicat a la prestigiosa revista internacional\u00a0<em>Human Reproduction<\/em>, s&#8217;ha realitzat en col\u00b7laboraci\u00f3 amb l&#8217;equip del Dr. Bassas, del Servei d&#8217;Andrologia de la Fundaci\u00f3 Puigvert.<\/p>\n<p>\u00a0<\/p>\n<p>La azoosp\u00e8rmia, abs\u00e8ncia total d&#8217;espermatozoides en l&#8217;ejaculat, provoca esterilitat, per\u00f2 no sempre descarta t\u00e8cniques de reproducci\u00f3 assistida com la ICSI (injecci\u00f3 intracitoplasm\u00e0tica d&#8217;espermatozoides) amb espermatozoides o esperm\u00e1tides recuperades del propi testicle. &#8220;Tot i que les determinacions hormonals i altres dades cl\u00edniques poden orientar-nos, encara falten m\u00e8todes de diagn\u00f2stic no invasiu que determinin amb precisi\u00f3 si hi ha espermatozoides al testicle en homes azoosp\u00e8rmics, condici\u00f3 determinant per a un tractament de reproducci\u00f3 assistida. Per tant, el diagn\u00f2stic sempre obliga a realitzar una bi\u00f2psia&#8221;, comenta el Dr. Bassas.<\/p>\n<p>\u00a0<\/p>\n<p>L&#8217;equip investigador ha determinat que la quantificaci\u00f3 de certes mol\u00e8cules d&#8217;\u00e0cid ribonucleic anomenades miRNAs, contingudes en unes ves\u00edcules del plasma seminal, poden utilitzar-se com biomarcadors no invasius de la pres\u00e8ncia d&#8217;espermatozoides en testicle, pel que representen una alternativa per identificar\u00a0<em>a priori<\/em>\u00a0aquells individus amb possibilitats reals de recuperaci\u00f3 positiva d&#8217;espermatozoides, evitant bi\u00f2psies innecess\u00e0ries. &#8220;El plasma seminal mostra una alta concentraci\u00f3 d&#8217;\u00e0cid ribonucleic (RNA), tant RNA missatger (mRNA) com d\u2019altres RNAs (miRNAs), que poden identificar-se i quantificar-se, el que els converteix en candidats a biomarcadors no invasius de diagn\u00f2stic i pron\u00f2stic&#8221; explica la Dra Larriba, responsable de la l\u00ednia de Gen\u00e8tica Molecular de la Fertilitat Masculina a l\u2019IDIBELL.<\/p>\n<p>\u00a0<\/p>\n<p>La troballa s&#8217;ha protegit mitjan\u00e7ant una patent i s&#8217;ha presentat com a pon\u00e8ncia convidada al 32\u00e8 Congr\u00e9s de la Societat Espanyola de Fertilitat (SEF), celebrat aquest mes de maig, i ha estat acceptada com a comunicaci\u00f3 oral al Congr\u00e9s de l&#8217;European Society of Human Reproduction and Embryology (ESHRE), que se celebrar\u00e0 a Barcelona el juliol de 2018.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Investigadors del grup de Gen\u00e8tica Molecular Humana de l&#8217;Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), liderats per la Dra Sara Larriba, han identificat un nou biomarcador no invasiu de la pres\u00e8ncia d&#8217;espermatozoides en els testicles d&#8217;homes azoosp\u00e8rmics, que representen el 10% de els casos d&#8217;esterilitat masculina. El treball, publicat a la prestigiosa revista internacional\u00a0Human Reproduction, s&#8217;ha [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":10576,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[396,334],"tags":[161],"publishpress_future_action":{"enabled":false,"date":"2024-05-04 21:41:03","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7635"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=7635"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7635\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/10576"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=7635"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=7635"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=7635"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}