L\u2019equip d\u2019investigaci\u00f3 en c\u00e0ncer colorectal (CCR) de l\u2019IDIBELL, liderat pel doctor V\u00efctor Moreno, ha participat en un estudi a gran escala que ha perm\u00e8s descriure 11 noves variants gen\u00e8tiques associades amb aquest tipus de c\u00e0ncer. Aquest estudi, publicat al Journal of the National Cancer Institute, proporciona un coneixement de l’arquitectura de la variaci\u00f3 gen\u00e8tica com\u00fa que contribueix a l’etiologia del CCR i millora la predicci\u00f3 del risc per al cribratge individualitzat.<\/p>\n
\u00a0<\/p>\n
La predisposici\u00f3 gen\u00e8tica \u00e9s un factor de risc important per al c\u00e0ncer colorectal (CCR), com ho demostra l’elevada freq\u00fc\u00e8ncia d’aquesta malaltia en les fam\u00edlies afectades. A m\u00e9s de les diverses mutacions conductores conegudes dels gens clau implicats en la tumorog\u00e8nesi, tamb\u00e9 existeixen polimorfismes gen\u00e8tics comuns implicats en el CCR. Cada un d’aquests polimorfismes confereix un petit augment en el risc, per\u00f2 la concurr\u00e8ncia de m\u00faltiples al\u00b7lels de risc en una persona defineix un risc rellevant que pot estar subjecte a un cribratge personalitzat.<\/p>\n
\u00a0<\/p>\n
El descobriment d’aquests polimorfismes requereix estudis a gran escala, i s’ha demostrat que a mesura que augmenta la mida de la mostra, es fan nous descobriments. L’equip d’investigaci\u00f3 del Dr. Moreno (Oncobell) forma part dels grans consorcis internacionals GECCO (Genetics and Epidemiology of Colorectal Cancer Consortium) i CORECT (Estudi transdisciplinari de c\u00e0ncer colorectal) que busquen variacions gen\u00e8tiques en tot el genoma, importants per dilucidar els factors de risc heretats i la seva interacci\u00f3 amb els factors de medi ambient.<\/p>\n
\u00a0<\/p>\n
El Dr. Moreno i la Sra. Henar Alonso d’ICO-IDIBELL, UB i CIBERESP van contribuir amb gaireb\u00e9 2.000 subjectes a aquest gran esfor\u00e7 del consorci per dur a terme un extens estudi d\u2019Associaci\u00f3 del Genoma (GWAS), amb un total de 165.315 subjectes analitzats. Els resultats, descriuen 11 noves variants associades amb CCR ap <5 \u00d7 10-8, que constitueixen l'augment del 14.7% en el risc relatiu familiar explicat pels al\u00b7lels de risc com\u00fa (del 10.3 % al 11.9%). Per arribar a aquests resultats, l'estudi va realitzar GWAS en casos i controls de CCR de descend\u00e8ncia europea, utilitzant un disseny de replicaci\u00f3 de descobriment, seguit de les proves de troballes noves en una mostra multi \u00e8tnica.<\/p>\n","protected":false},"excerpt":{"rendered":"
L\u2019equip d\u2019investigaci\u00f3 en c\u00e0ncer colorectal (CCR) de l\u2019IDIBELL, liderat pel doctor V\u00efctor Moreno, ha participat en un estudi a gran escala que ha perm\u00e8s descriure 11 noves variants gen\u00e8tiques associades amb aquest tipus de c\u00e0ncer. Aquest estudi, publicat al Journal of the National Cancer Institute, proporciona un coneixement de l’arquitectura de la variaci\u00f3 gen\u00e8tica com\u00fa […]<\/p>\n","protected":false},"author":6,"featured_media":7610,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[332,375],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-13 00:42:05","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7609"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=7609"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7609\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/7610"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=7609"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=7609"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=7609"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}