A trav\u00e9s d\u2019un estudi bioinform\u00e0tic de gran quantitat de dades, investigadors de l\u2019IDIBELL – ICO (ProCURE, programa Oncobell) han contribu\u00eft a desxifrar les caracter\u00edstiques metab\u00f2liques de diferents tipus de c\u00e0ncer. A m\u00e9s, aquest estudi ha identificat multitud de noves vulnerabilitats que obren portes a tractaments m\u00e9s precisos del c\u00e0ncer. La recerca, publicada a la revista Cancer Research, ha sigut possible gr\u00e0cies a la col\u00b7laboraci\u00f3 establerta amb el grup del professor Joaqu\u00edn Dopazo de la \u201cFundaci\u00f3n Andaluza Progreso y Salud\u201d i l\u2019\u201cInstituto Nacional de Bioinform\u00e1tica (INB)\u201d.<\/p>\n
\u00a0<\/p>\n
\u201cEl metabolisme cel\u00b7lular es troba reorganitzat o reprogramat en el c\u00e0ncer; aquesta caracter\u00edstica contribueix de forma decisiva a la progressi\u00f3 de la malaltia i formaci\u00f3 de met\u00e0stasis\u201d, explica el Dr. Miquel \u00c1ngel Pujana, investigador IDIBELL-ICO. \u201cTanmateix es desconeix el perfil metab\u00f2lic de molts tipus de tumors\u201d, afegeix.<\/p>\n
\u00a0<\/p>\n
L\u2019equip d\u2019investigadors va partir de 9.428 mostres corresponents a 25 tipus de c\u00e0ncers per tal d\u2019elucidar les caracter\u00edstiques metab\u00f2liques de cadascun d\u2019ells. \u201cAquesta informaci\u00f3, combinada amb dades d\u2019expressi\u00f3 g\u00e8nica, esdev\u00e9 una valu\u00f3s compendi de perfils metab\u00f2lics en c\u00e0ncer i ens permet establir relacions entre ells i respecte al pron\u00f2stic de la malaltia\u201d, afegeix el Dr. Pujana.\u00a0<\/p>\n
\u00a0<\/p>\n
En els darrers anys, el metabolisme del c\u00e0ncer ha esdevingut una \u00e0rea de molt inter\u00e8s \u00a0pel desenvolupament de noves i precises estrat\u00e8gies terap\u00e8utiques. \u201cEn el nostre estudi, proposem inhibir diferents dianes metab\u00f2liques com a nova estrat\u00e8gia terap\u00e8utica per evitar la progressi\u00f3 de la malaltia\u201d, comenta l\u2019investigador Oncobell. \u00a0
\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"
Gr\u00e0cies a un estudi bioinform\u00e0tic de 9.428 mostres tumorals, tamb\u00e9 s\u2019identifiquen vulnerabilitats capaces de donar lloc a nous tractaments m\u00e9s precisos<\/p>\n","protected":false},"author":6,"featured_media":7581,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[332,390],"tags":[],"class_list":["post-7580","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cancer","category-cancer-de-mama"],"publishpress_future_action":{"enabled":false,"date":"2024-11-30 01:34:44","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7580","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=7580"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7580\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/7581"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=7580"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=7580"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=7580"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}