L\u2019investigador \u00c1lvaro Ayt\u00e9s, cap del grup de recerca en c\u00e0ncer de pr\u00f2stata de l’IDIBELL-ICO (Programa Contra la Resist\u00e8ncia al C\u00e0ncer – ProCURE, Oncobell), ha rebut un ajut \u201cIdea Development Award\u201d, per valor de 400.000$, del Programa d’investigaci\u00f3 m\u00e8dica (CDMRP) del Departament de Defensa dels Estats Units (DoD). Aquest guard\u00f3 finan\u00e7ar\u00e0 un projecte de recerca innovador sobre el c\u00e0ncer de pr\u00f2stata que vol entendre per qu\u00e8 les c\u00e8l\u00b7lules de c\u00e0ncer de pr\u00f2stata s\u00f3n resistents als tractaments est\u00e0ndard i identificar nous objectius terap\u00e8utics.<\/p>\n
\u00a0<\/p>\n
Malgrat aven\u00e7os impressionants assolits en els darrers anys, el c\u00e0ncer de pr\u00f2stata continua sent el c\u00e0ncer m\u00e9s diagnosticat i la tercera causa m\u00e9s important de mortalitat relacionada amb el c\u00e0ncer entre els homes als EUA. Afortunadament, la seq\u00fcenciaci\u00f3 del genoma per a la medicina personalitzada est\u00e0 evolucionant r\u00e0pidament. “Avui, tenim una imatge precisa del panorama de mutacions associades al c\u00e0ncer de pr\u00f2stata; el repte \u00e9s identificar les veritables mutacions responsables i els \u201ctalons d’Aquil\u00b7les” que sorgeixen durant la progressi\u00f3 de la malaltia i que poden considerar-se vulnerabilitats”, explica el Dr. \u00c1lvaro Ayt\u00e9s.<\/p>\n
\u00a0<\/p>\n
Les dades preliminars obtingudes per l\u2019equip del doctor Ayt\u00e9s assenyalaven una nova diana potencial (anomenada NSD2) com a ter\u00e0pia en c\u00e0ncer de pr\u00f2stata; ara, el projecte finan\u00e7at pel DoD t\u00e9 com per objectiu validar aquesta diana molecular utilitzant sofisticats models de c\u00e0ncer de pr\u00f2stata en ratolins gen\u00e8ticament modificats aproximacions de biologia computacional i eines d’edici\u00f3 del genoma. “Volem entendre tamb\u00e9 la biologia subjacent que explica com aquesta nova diana afavoreix l’agressivitat del c\u00e0ncer de pr\u00f2stata i si pot ser explotada com a biomarcador de predicci\u00f3”, afegeix el Dr. Ayt\u00e9s.<\/p>\n
\u00a0<\/p>\n
“Creiem fermament que aquest projecte pot proporcionar les dades precl\u00edniques necess\u00e0ries per moure immediatament f\u00e0rmacs contra aquestes dianes a assaigs cl\u00ednics”, afirma l’investigador IDIBELL-ICO. En aquest sentit, l’estreta col\u00b7laboraci\u00f3 del grup de recerca amb col\u00b7lectius de pacients com The Prostate Net, UsToo o la Fundaci\u00f3 Movember, i el destacat grup de col\u00b7laboradors implicats en el projecte asseguren que els resultats i descobriments es traduiran a l\u2019\u00e0mbit cl\u00ednic un cop assolits.<\/p>\n
\u00a0<\/p>\n
La missi\u00f3 del Programa d\u2019investigaci\u00f3 m\u00e8dica del congr\u00e9s dels EUA i el Programa de Recerca sobre C\u00e0ncer de Pr\u00f2stata (PCRP) del DoD \u00e9s finan\u00e7ar recerca innovadora que condueixi a convertir el c\u00e0ncer de pr\u00f2stata en una malaltia no mortal i a millorar el benestar dels homes que pateixen la malaltia. De forma espec\u00edfica, la PCRP busca promoure estudis translacionals amb rellev\u00e0ncia cl\u00ednica a curt termini.<\/p>\n
\u00a0<\/p>\n
Aquest premi \u00e9s un reconeixement a l’estrat\u00e8gia cient\u00edfica de l’ICO i de l’IDIBELL, que el 2016 va reclutar al doctor Ayt\u00e9s des de la Columbia Medical University of New York per liderar el laboratori de Recerca contra el C\u00e0ncer de Pr\u00f2stata en el Programa Contra la Resist\u00e8ncia Terap\u00e8utica del C\u00e0ncer (ProCURE), dins del marc del recentment creat programa Oncobell. El Dr. Ayt\u00e9s ha rebut premis de l’Associaci\u00f3 Europea de Recerca en Urologia, aix\u00ed com de l’Institut Nacional de Salut, entre d’altres.
\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"
El projecte del Dr. \u00c1lvaro Ayt\u00e9s (IDIBELL – ICO \/ ProCure) rep un ajut \u201cIdea Development Award\u201d del Departament de Defensa dels Estats Units (DoD) en el marc del seu Programa de Recerca en C\u00e0ncer de Pr\u00f2stata<\/p>\n","protected":false},"author":6,"featured_media":10545,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[332,395],"tags":[],"class_list":["post-7577","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cancer","category-mecanismes-de-resistencia-i-progressio-en-el-cancer-de-prostata"],"publishpress_future_action":{"enabled":false,"date":"2024-11-29 19:39:44","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7577","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=7577"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7577\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/10545"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=7577"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=7577"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=7577"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}