El risc de desenvolupar c\u00e0ncer de mama est\u00e0 en gran part determinat per la capacitat de les c\u00e8l\u00b7lules de reparar danys en el seu ADN i, a la vegada, per la regulaci\u00f3 de les \u201cc\u00e8l\u00b7lules mare\u201d que donen origen als tumors. Tanmateix, es desconeix com aquests dos processos fonamentals es coregulen.<\/p>\n
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En un estudi recent, investigadors IDIBELL – ICO del programa ProCURE, Oncobell,\u00a0 en col\u00b7laboraci\u00f3 amb investigadors del Princess Margaret Cancer Center (Toronto, Canada), descriuen el paper del supressor tumoral RNF8 en la regulaci\u00f3 de la resposta a danys en l\u2019ADN i el control de les c\u00e8l\u00b7lules mare. Els equips de recerca han demostrat que RNF8 coordina ambd\u00f3s processos, modulant tant la resposta al dany com l\u2019activaci\u00f3 del receptor NOTCH, que regula els progenitors de les c\u00e8l\u00b7lules epitelials mam\u00e0ries que poden arribar-se a convertir en tumorals.<\/p>\n
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D\u2019altra banda, l\u2019estudi demostra que tumors amb nivells baixos de RNF8 poden ser tractats efectivament amb la combinaci\u00f3 de inhibidors dels receptors NOTCH i PARP. \u201cAquesta observaci\u00f3 obre la possibilitat d\u2019establir una nova ter\u00e0pia precisa i efica\u00e7 per determinades pacients de c\u00e0ncer de mama\u201d, explica el Dr. Miquel \u00c0ngel Pujana, cap del grup de recerca en c\u00e0ncer de mama de l\u2019IDIBELL i autor de l\u2019estudi.<\/p>\n
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Cada any es produeixen uns 4500 nous casos i 900 morts per c\u00e0ncer de mama a Catalunya. El c\u00e0ncer de mama \u00e9s, de lluny, el m\u00e9s freq\u00fcent en les dones, tant en els pa\u00efsos desenvolupats com en els pa\u00efsos en desenvolupament. El Mes de Sensibilitzaci\u00f3 sobre el C\u00e0ncer de Mama, que se celebra a tot el m\u00f3n cada mes d’octubre, contribueix a augmentar l’atenci\u00f3 i el suport prestats a la sensibilitzaci\u00f3, la detecci\u00f3 preco\u00e7, el tractament i les cures pal\u00b7liatives.<\/p>\n","protected":false},"excerpt":{"rendered":"
El risc de desenvolupar c\u00e0ncer de mama est\u00e0 en gran part determinat per la capacitat de les c\u00e8l\u00b7lules de reparar danys en el seu ADN i, a la vegada, per la regulaci\u00f3 de les \u201cc\u00e8l\u00b7lules mare\u201d que donen origen als tumors. Tanmateix, es desconeix com aquests dos processos fonamentals es coregulen. \u00a0 \u00a0 En un […]<\/p>\n","protected":false},"author":6,"featured_media":10542,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[332,390],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-12 18:42:28","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7572"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=7572"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7572\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/10542"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=7572"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=7572"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=7572"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}