{"id":7529,"date":"2018-12-13T00:00:00","date_gmt":"2018-12-12T23:00:00","guid":{"rendered":"https:\/\/idibell.cat\/blog\/2018\/12\/13\/lidibell-i-lhospital-de-bellvitge-desenvolupen-un-tractament-per-guanyar-la-batalla-a-les-infeccions-hospitalaries-sense-lus-dantibiotics\/"},"modified":"2020-08-07T10:41:57","modified_gmt":"2020-08-07T08:41:57","slug":"lidibell-i-lhospital-de-bellvitge-desenvolupen-un-tractament-per-guanyar-la-batalla-a-les-infeccions-hospitalaries-sense-lus-dantibiotics","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2018\/12\/lidibell-i-lhospital-de-bellvitge-desenvolupen-un-tractament-per-guanyar-la-batalla-a-les-infeccions-hospitalaries-sense-lus-dantibiotics\/","title":{"rendered":"L&#8217;IDIBELL i L\u2019Hospital de Bellvitge desenvolupen un tractament per guanyar la batalla a les infeccions hospital\u00e0ries sense l\u2019\u00fas d\u2019antibi\u00f2tics"},"content":{"rendered":"<p>La resist\u00e8ncia dels bacteris als antibi\u00f2tics \u00e9s un dels problemes m\u00e9s importants als quals s\u2019enfronta la salut p\u00fablica a nivell mundial. El continu creixement de les infeccions causades per aquests microbis pot causar m\u00e9s de 10 milions de morts anuals l\u2019any 2050, com succe\u00efa a l\u2019era preantibi\u00f2tica.<\/p>\n<p>La majoria d\u2019aquestes infeccions s\u2019adquireixen dins dels hospitals, per la qual cosa, a m\u00e9s, grans \u00e8xits de la medicina com ara els trasplantaments o la immunoter\u00e0pia contra el c\u00e0ncer poden perillar per elles. El problema \u00e9s especialment urgent a les UCIs. El 70% dels pacients ingressats m\u00e9s de 7 dies desenvolupen una infecci\u00f3 i reben tractaments antibi\u00f2tics, amb uns costos de milers de milions per als sistemes de salut a nivell mundial.<\/p>\n<p>Investigadors de l\u2019Hospital Universitari de Bellvitge i de l\u2019Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) han desenvolupat uns glicopol\u00edmers que permeten eliminar anticossos que s\u2019uneixen als bacteris Gram-negatius sense causar-los cap mal. Aquests anticossos (anomenats bloquejants) s\u00f3n utilitzats pels bacteris com a escut.<\/p>\n<p>Si s\u2019eliminen els anticossos bloquejants, s\u2019elimina l\u2019escut i els anticossos amb capacitat de matar els bacteris poden actuar de forma immediata. Aix\u00f2 representa un gran avantatge dels glicopol\u00edmers comparat amb altres ter\u00e0pies com ara les vacunes, que necessiten de diverses setmanes per poder generar una immunitat protectora.<\/p>\n<p>El nou tractament, que pot tenir un important impacte sanitari i econ\u00f2mic per als sistemes de salut, ha estat patentat internacionalment. A comen\u00e7aments del 2018 es va crear l\u2019empresa spin-off de l\u2019IDIBELL RemAb Therapeutics (<a href=\"https:\/\/remabtx.com;\">https:\/\/remabtx.com;<\/a> @RemAb_Tx), que est\u00e0 actualment executant els procediments precl\u00ednics amb les autoritats regulat\u00f2ries i una ronda d\u2019inversi\u00f3, amb l\u2019objectiu d\u2019iniciar els primers assajos cl\u00ednics dels glicoconjugats en humans a principis de l\u2019any 2020.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>El nou tractament evitaria que m\u00e9s de 4 milions de pacients ingressats a les Unitats de Cures Intensives (UCI) a nivell mundial desenvolupin infeccions i necessitin antibi\u00f2tics<\/p>\n","protected":false},"author":6,"featured_media":10517,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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