Investigadors de l’Institut d’Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) i de l\u2019Institut Catal\u00e0 d\u2019Oncologia (programa ProCURE), liderats pel Dr. David G. Mollev\u00ed i amb la Dra. Natalia Guill\u00e9n D\u00edaz-Maroto com a primera autora, publiquen a Clinical Cancer Research les bases per a noves ter\u00e0pies contra el c\u00e0ncer colorectal. L\u2019estudi est\u00e0 integrat dins el programa de recerca Oncobell, el programa de l\u2019IDIBELL destinat a la investigaci\u00f3 de ter\u00e0pies experimentals i mecanismes moleculars en c\u00e0ncer.<\/p>\n
\u00a0<\/p>\n
\u201cHem descobert que si inactivem dues prote\u00efnes, anomenades TAK1 i TGFBR1, que participen en la senyalitzaci\u00f3 cel\u00b7lular del teixit normal associat als tumors, les c\u00e8l\u00b7lules tumorals s\u00f3n m\u00e9s sensibles a la quimioter\u00e0pia i es redueix la capacitat de met\u00e0stasi dels tumors\u201d, comenta el Dr. Mollev\u00ed.<\/p>\n
\u00a0<\/p>\n
En un tumor desenvolupat trobem diferents tipus de c\u00e8l\u00b7lules. Per una banda, les pr\u00f2piament canceroses, i per l\u2019altra, hi ha c\u00e8l\u00b7lules normals, anomenades gen\u00e8ricament estroma. Entre elles, les m\u00e9s nombroses s\u00f3n els fibroblasts, que proporcionen sosteniment a mode de bastida. Aquests fibroblasts a trav\u00e9s d\u2019aquestes dues prote\u00efnes (TAK1 i TGFBR1) proporcionen mol\u00e8cules i factors que nodreixen a les c\u00e8l\u00b7lules tumorals i faciliten que aquestes siguin invisibles als tractaments de quimioter\u00e0pia.<\/p>\n
\u00a0<\/p>\n
Una de les moltes l\u00ednies d\u2019estudi que existeixen per combatre el c\u00e0ncer \u00e9s influir en la interacci\u00f3 entre l\u2019estroma i el tumor, per fer que aquest sigui m\u00e9s vulnerable ja que s\u2019interfereix en el seu desenvolupament. D\u2019aquesta manera, els tumors es poden tractar amb quimioter\u00e0pia amb menys possibilitat de que tornin a apar\u00e8ixer.\u00a0<\/p>\n
\u00a0<\/p>\n
\u201cAquest nou descobriment aporta raons per crear noves ter\u00e0pies contra c\u00e0ncers colorectals especialment en el subgrup de tumors m\u00e9s abundant en fibroblasts\u201d afegeix Mollev\u00ed.<\/p>\n
\u00a0<\/p>\n
S\u2019espera les bases descobertes per aquest estudi permetin desenvolupar noves ter\u00e0pies en el futur.
\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"
El descobriment es basa en afectar el teixit associat al tumor, enlloc d\u2019atacar directament el tumor<\/p>\n","protected":false},"author":6,"featured_media":10496,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[332,346],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-12 03:05:59","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7487"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=7487"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7487\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/10496"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=7487"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=7487"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=7487"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}