{"id":7463,"date":"2019-06-12T00:00:00","date_gmt":"2019-06-11T22:00:00","guid":{"rendered":"https:\/\/idibell.cat\/blog\/2019\/06\/12\/investigadors-de-lidibell-hub-correlacionen-negativament-un-neuropeptid-amb-les-funcions-executives-en-pacients-amb-anorexia\/"},"modified":"2022-01-11T15:34:33","modified_gmt":"2022-01-11T14:34:33","slug":"investigadors-de-lidibell-hub-correlacionen-negativament-un-neuropeptid-amb-les-funcions-executives-en-pacients-amb-anorexia","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2019\/06\/investigadors-de-lidibell-hub-correlacionen-negativament-un-neuropeptid-amb-les-funcions-executives-en-pacients-amb-anorexia\/","title":{"rendered":"Investigadors de l\u2019IDIBELL-HUB correlacionen negativament un neurop\u00e8ptid amb les funcions executives en pacients amb anor\u00e8xia"},"content":{"rendered":"<p>Investigadors de l&#8217;Institut d&#8217;Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) i del grup de Trastorns de la Conducta Aliment\u00e0ria, de l\u2019Hospital Universitari Bellvitge (HUB), liderats pel Dr. <strong>Fernando Fern\u00e1ndez-Aranda<\/strong>, publiquen a <em>Scientific Reports (Nature)<\/em> un estudi que correlaciona negativament la concentraci\u00f3 d\u2019<strong>orexina A<\/strong> (un neurop\u00e8ptid) amb les funcions executives en pacients anor\u00e8xiques. L\u2019estudi s\u2019emmarca en el programa de recerca \u201c<strong>neurocognici\u00f3 i situacions extremes de pes des de l\u2019anor\u00e8xia a la obesitat<\/strong>\u201d, que duen a terme al Centre d\u2019Investigaci\u00f3 Biom\u00e8dica en Red d\u2019Obesitat i Nutrici\u00f3 (CIBEROBN), del qual tamb\u00e9 han participat altres grups en l\u2019estudi.<\/p>\n<p><em>&#8220;Hem avaluat l\u2019associaci\u00f3 entre la concentraci\u00f3 del neurop\u00e8ptid orexina A del plasma sanguini i les facultats neuropsicol\u00f2giques en dones adultes, i hem pogut establir-hi una correlaci\u00f3 negativa, \u00e9s a dir, que a m\u00e9s concentraci\u00f3 d\u2019orexina, les pacients presentaven un empobriment de les funcions executives\u201d<\/em> comenta el Dr. Fern\u00e1ndez-Aranda. En l\u2019estudi hi han participat <strong>102 dones<\/strong> adultes, 51 d\u2019elles amb<strong> anor\u00e8xia nerviosa<\/strong>, totes elles tractades al HUB; l\u2019altra meitat eren dones sanes. Els representants masculins s\u2019han excl\u00f2s degut a la baixa prevalen\u00e7a d\u2019homes en aquest trastorn.b<\/p>\n<p>En pacients amb <strong>anor\u00e8xia<\/strong> se sol observar alteracions en la presa de decisions, dificultats per adaptar-se a situacions noves (inflexibilitat i per veure el context general del que observen (fixaci\u00f3 excessiva en els detalls), alta rigidesa i perfeccionisme i, en alguns casos, nivells elevats d\u2019impulsivitat.<\/p>\n<p>Les <strong>orexines<\/strong>, altrament anomenades hipocretines, s\u00f3n neurop\u00e8ptids (subst\u00e0ncies del sistema nervi\u00f3s) que fan servir les neurones per comunicar-se entre elles. En estudis anteriors s\u2019ha observat que les orexines estan implicades en una diversitat de mecanismes, com per exemple la ingesta de menjar i processos de cognici\u00f3, trastorns de la son, entre altres.<\/p>\n<p>Un dels objectius principals del grup del Dr. Fern\u00e1ndez Aranda \u00e9s estudiar la <strong>interacci\u00f3 entre factors biol\u00f2gics, cognitius i cl\u00ednics<\/strong>. Per aconseguir-ho, busquen marcadors neurobiol\u00f2gics que puguin explicar els processos cognitius i els de les malalties (com\u00a0 l\u2019anor\u00e8xia, la bul\u00edmia o l\u2019obesitat) i d\u2019addiccions conductuals. \u201c\u00c9s per aix\u00f2, que vam voler estudiar si la orexina A podia tenir un paper important en trastorns psiqui\u00e0trics com l\u2019anor\u00e8xia\u201d, justifica el Dr. Fern\u00e1ndez Aranda.<\/p>\n<p>Un cop els pacients amb anor\u00e8xia s\u2019han recuperat, els nivells de <strong>presa de decisions<\/strong> tamb\u00e9 s\u00f3n m\u00e9s adequats, \u00e9s a dir, que s\u00f3n reversibles. Per aix\u00f2, seria de gran inter\u00e8s explorar si la millora en la presa de decisions observada en la recuperaci\u00f3 de l\u2019anor\u00e8xia, est\u00e0 relacionada amb canvis en els nivells d\u2019orexina A. D\u2019aquesta manera, podr\u00edem assegurar un biomarcador amb potencials aplicacions cl\u00edniques.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Investigadors de l&#8217;Institut d&#8217;Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) i del grup de Trastorns de la Conducta Aliment\u00e0ria, de l\u2019Hospital Universitari Bellvitge (HUB), liderats pel Dr. Fernando Fern\u00e1ndez-Aranda, publiquen a Scientific Reports (Nature) un estudi que correlaciona negativament la concentraci\u00f3 d\u2019orexina A (un neurop\u00e8ptid) amb les funcions executives en pacients anor\u00e8xiques. L\u2019estudi s\u2019emmarca en el programa [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[340,457,515,429],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-13 22:20:54","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7463"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=7463"}],"version-history":[{"count":3,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7463\/revisions"}],"predecessor-version":[{"id":20177,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7463\/revisions\/20177"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=7463"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=7463"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=7463"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}