{"id":7461,"date":"2019-06-17T00:00:00","date_gmt":"2019-06-16T22:00:00","guid":{"rendered":"https:\/\/idibell.cat\/blog\/2019\/06\/17\/les-analisis-moleculars-podrien-millorar-la-deteccio-precoc-i-la-prevencio-del-cancer-dendometri\/"},"modified":"2021-07-28T14:57:58","modified_gmt":"2021-07-28T12:57:58","slug":"les-analisis-moleculars-podrien-millorar-la-deteccio-precoc-i-la-prevencio-del-cancer-dendometri","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2019\/06\/les-analisis-moleculars-podrien-millorar-la-deteccio-precoc-i-la-prevencio-del-cancer-dendometri\/","title":{"rendered":"Les an\u00e0lisis moleculars podrien millorar la detecci\u00f3 preco\u00e7 i la prevenci\u00f3 del c\u00e0ncer d\u2019endometri"},"content":{"rendered":"

L\u2019\u00fas de biomarcadors moleculars en els mostrejos m\u00ednimament invasius obre una perspectiva prometedora per la detecci\u00f3 preco\u00e7 del c\u00e0ncer d\u2019endometri. Aquesta \u00e9s la conclusi\u00f3 a la qual han arribat, en el seu darrer treball, els membres del grup de recerca Screenwide<\/i>, format per investigadores i investigadors de l\u2019Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) i de l\u2019Institut Catal\u00e0 d\u2019Oncologia (ICO-Hospitalet). L\u2019article que han elaborat, i que ha estat publicat a la revista International Journal of Cancer, <\/i>remarca els buits que existeixen en el coneixement actual per a poder accelerar la implementaci\u00f3 de noves tecnologies, amb l\u2019objectiu de millorar el cribratge i la detecci\u00f3 preco\u00e7 en entorns cl\u00ednics d\u2019aquest tipus de c\u00e0ncer de la dona.<\/span><\/span><\/span><\/p>\n

Gr\u00e0cies a la continu\u00eftat anat\u00f2mica entre la cavitat uterina i el coll de l\u2019\u00fater, l\u2019explotaci\u00f3 gen\u00f2mica del material biol\u00f2gic provinent de la prova de Papanicolaou, o citologia cervical, que s\u2019utilitza de rutina en programes de prevenci\u00f3 de c\u00e0ncer de c\u00e8rvix, representen, juntament amb altres m\u00e8todes de mostreig no invasiu, una oportunitat \u00fanica per detectar signes de malaltia del tracte genital superior. Aquest fet pot contribuir a millorar el diagn\u00f2stic i la prevenci\u00f3 del c\u00e0ncer d\u2019endometri. <\/span><\/span><\/span><\/p>\n

Actualment, les estrat\u00e8gies de detecci\u00f3 dels signes d\u2019aquest c\u00e0ncer es limiten a les poblacions d\u2019alt risc i en dones simptom\u00e0tiques, ja que el 90 % dels c\u00e0ncers d\u2019endometri es presenten amb sagnat anormal. Les noves an\u00e0lisis no nom\u00e9s beneficiaran de forma clara aquests casos: el seu potencial podria repercutir en un millor cribratge de les dones asimptom\u00e0tiques. Les proves moleculars poden ajudar a refinar els algoritmes de diagn\u00f2stic actuals, ja que reduiran la taxa de frac\u00e0s del diagn\u00f2stic histol\u00f2gic cl\u00e0ssic. A m\u00e9s, els m\u00e8todes m\u00ednimament invasius son m\u00e9s apropiats en poblacions \u00e0mplies de dones asimptom\u00e0tiques, ja que es toleren molt millor. Les primeres dones en beneficiar-se d\u2019aquest nou enfoc en la detecci\u00f3 seran segurament les que tenen antecedents familiars de c\u00e0ncer, com en el cas de la s\u00edndrome de Lynch, degut al seu elevat risc subjacent.<\/span><\/span><\/span><\/p>\n

El grup Screenwide<\/i> es cre\u00e0 el 2016 amb l\u2019objectiu de desenvolupar eines de detecci\u00f3 preco\u00e7 i cribratge del c\u00e0ncer d\u2019endometri i ovari. L\u2019equip est\u00e0 liderat pel grup d\u2019epidemiologia (Dra. Laura Costas), amb l\u2019alian\u00e7a dels grups de patologia (Dr. Xavier Matias-Guiu), ginecologia (Dr. Jordi Ponce), oncologia (Dr. Josep Maria Piulats), Procure (Dr. \u00c0lvaro Ayt\u00e9s), i consell gen\u00e8tic (Dr. Joan Brunet). El grup compta amb la col\u00b7laboraci\u00f3 internacional del Consorci d\u2019Epidemiologia del C\u00e0ncer d\u2019Endometri (Dra. Sara Olson), de la John Hopkins University (Dr. Bert Vogelstein) i del Consorci Forecee (Dr. Martin Widschwendter); i, a nivell nacional, amb la del Vall d\u2019Hebron Institut de Recerca (VHIR; Dra. Eva Col\u00e0s), entre d\u2019altres. Durant els darrers dos anys, l\u2019esfor\u00e7 combinat d\u2019aquest grup multidisciplinari ha perm\u00e8s reclutar gaireb\u00e9 500 dones i reunir m\u00e9s de 1600 mostres biol\u00f2giques. Tota aquesta informaci\u00f3 ser\u00e0 la base per a poder avaluar noves estrat\u00e8gies de detecci\u00f3 del c\u00e0ncer d\u2019endometri i ovari de forma preco\u00e7.<\/span><\/span><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Investigadors de l\u2019IDIBELL i de l\u2019ICO lideren la proposta d\u2019avaluar an\u00e0lisis gen\u00f2miques en citologies cervicals per millorar la detecci\u00f3 del c\u00e0ncer de la cavitat uterina<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[332,365,337,395,487],"tags":[],"class_list":["post-7461","post","type-post","status-publish","format-standard","hentry","category-cancer","category-cancer-ginecologic","category-infeccions-i-cancer","category-mecanismes-de-resistencia-i-progressio-en-el-cancer-de-prostata","category-recerca-de-serveis-de-salut-en-cancer"],"publishpress_future_action":{"enabled":false,"date":"2024-12-02 00:12:04","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7461","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=7461"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7461\/revisions"}],"predecessor-version":[{"id":18603,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7461\/revisions\/18603"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=7461"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=7461"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=7461"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}