\u2022\u00a0\u00a0 \u00a0La identificaci\u00f3 de signatures neurals espec\u00edfiques pot ajudar a desenvolupar biomarcadors espec\u00edfics i tractaments personalitzats per a la malaltia de Huntington.
\u2022\u00a0\u00a0 \u00a0Els resultats subratllen el valor dels enfocaments multimodals en la caracteritzaci\u00f3 de patrons heterogenis de neurodegeneraci\u00f3.<\/p>\n
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Investigadores del grup Cognici\u00f3 i Plasticitat Cerebral de l’Institut d’Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) i de l\u2019Institut de Neuroci\u00e8ncies de la Universitat de Barcelona (UBNeuro), amb la col\u00b7laboraci\u00f3 de la Universitat de Radboud, als Pa\u00efsos Baixos, han identificat dos patrons espec\u00edfics d’alteracions cerebrals subjacents a dos perfils cl\u00ednics de la malaltia de Huntington. L’estudi, publicat a “Neuroimage: Clinical”, pot ajudar a desenvolupar biomarcadors espec\u00edfics i tractaments personalitzats per a cada perfil d’aquesta malaltia minorit\u00e0ria.<\/p>\n
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La recerca, liderada per les doctores Estela C\u00e0mara i Ruth de Diego i que compta amb la investigadora predoctoral Clara Garc\u00eda Gorro com a primera autora, amplia el coneixement sobre la malaltia de Huntington. Aquesta malaltia gen\u00e8tica neurodegenerativa es caracteritza per generar d\u00e8ficits motrius, cognitius i psiqui\u00e0trics, per\u00f2 existeix \u201cuna heterogene\u00eftat molt gran a nivell simptom\u00e0tic entre els pacients, de manera que vam decidir investigar les bases neurobiol\u00f2giques d’aquestes difer\u00e8ncies per veure si pod\u00edem enlla\u00e7ar-les amb els perfils cl\u00ednics”, explica la doctora de Diego, investigadora ICREA.\u00a0<\/p>\n
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Per a l\u2019estudi, els investigadors van utilitzar una t\u00e8cnica d’an\u00e0lisi de fusi\u00f3 multimodal que permet combinar diferents tipus de modalitats d’imatges per resson\u00e0ncia magn\u00e8tica. “Aquest tipus d’an\u00e0lisi ens permet integrar la informaci\u00f3 de les diferents modalitats i estudiar aix\u00ed el cervell i el patr\u00f3 de neurodegeneraci\u00f3 de manera m\u00e9s global, el que fa possible identificar alteracions cerebrals m\u00e9s subtils”, explica la doctora C\u00e0mara.<\/p>\n
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L\u2019an\u00e0lisi de la relaci\u00f3 entre els s\u00edmptomes de la malaltia i les mesures de les alteracions estructurals de la mat\u00e8ria blanca i gris va permetre als investigadors establir que els s\u00edmptomes cognitius i motors compartien una base neurobiol\u00f2gica comuna, mentre que el domini psiqui\u00e0tric presentava una signatura neural diferenciada.<\/p>\n
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“Els s\u00edmptomes cognitius i motrius es van associar de forma conjunta amb un patr\u00f3 de reducci\u00f3 de la mat\u00e8ria grisa, el gruix cortical i la integritat de la subst\u00e0ncia blanca en regions cerebrals responsables de l’execuci\u00f3 de moviments i del processament de diferents funcions cognitives, com la mem\u00f2ria, planificaci\u00f3 o processament visual-espacial. Els s\u00edmptomes depressius, d’altra banda, estaven associats a un patr\u00f3 molt diferent, caracteritzat per un menor gruix en l’escor\u00e7a cerebral en regions responsables del processament d’emocions t\u00edpicament associades a alteracions psiqui\u00e0triques”, afegeix la doctora Garc\u00eda Gorro.<\/p>\n
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Aquests resultats aporten una nova visi\u00f3 sobre una malaltia tradicionalment considerada com a entitat uniforme, i impulsen noves l\u00ednies de recerca que tinguin en compte aquestes difer\u00e8ncies qualitatives individuals. “Els nostres resultats s\u00f3n especialment rellevants en el context dels assajos cl\u00ednics, ja que es podrien utilitzar per definir biomarcadors espec\u00edfics per a cada perfil simptomatol\u00f2gic, fins i tot abans que apareguin signes cl\u00ednics”, afirma la doctora C\u00e0mara, i afegeix que “a m\u00e9s a m\u00e9s, estem obrint una porta a la medicina personalitzada en la malaltia de Huntington, ja que augmenta la probabilitat de trobar tractaments individualitzats orientats a alteracions cognitives, motrius i psiqui\u00e0triques especifiques\u201d.<\/p>\n
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En l’estudi han participat tamb\u00e9 diferents hospitals de Barcelona, com l’Hospital Universitari de Bellvitge, l\u2019Hospital de la Santa Creu i Sant Pau, l\u2019Hospital Cl\u00ednic de Barcelona i l’Hospital Mare de D\u00e9u de la Merc\u00e8. Aix\u00f2 ha perm\u00e8s investigar amb una mostra de pacients gran, fet d\u2019especial import\u00e0ncia en una malaltia minorit\u00e0ria com \u00e9s la malaltia de Huntington.
\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"
Els perfils cognitiu-motriu i psiqui\u00e0tric de la malaltia de Huntington mostren un patr\u00f3 d\u2019alteracions cerebrals diferenciat<\/p>\n","protected":false},"author":6,"featured_media":10471,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[368,340],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-04 22:39:57","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7456"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=7456"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7456\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/10471"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=7456"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=7456"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=7456"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}