Investigadors del grup de cognici\u00f3 i plasticitat cerebral del l\u2019Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) i de l\u2019Institut de Neuroci\u00e8ncies de la Universitat de Barcelona (UBNeuro) han liderat un innovador estudi que identifica modificacions en la connectivitat de la mat\u00e8ria blanca cerebral associades a la naturalesa heterog\u00e8nia de l\u2019apatia en la malaltia de Huntington (HD), fent que sigui possible utilitzar aquesta s\u00edndrome com a biomarcador de progressi\u00f3 de la malaltia. Les seves troballes, publicades a Neuroimage: Clinical, tamb\u00e9 obren una porta per al tractament personalitzat de l\u2019apatia com a s\u00edndrome multidimensional en d\u2019altres trastorns neurodegeneratius.<\/p>\n
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“El nostre objectiu era estudiar l\u2019apatia com un s\u00edndrome multidimensional i explorar, per primera vegada, la relaci\u00f3 entre els diferents subtipus d’apatia i la connectivitat de la mat\u00e8ria blanca en la malaltia de Huntington”, afirma la doctora Estela C\u00e0mara, autora principal.\u00a0<\/p>\n
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Malgrat l\u2019apatia s\u2019identifica normalment amb una falta d\u2019inter\u00e8s i motivaci\u00f3 generalitzada, \u00e9s una s\u00edndrome molt m\u00e9s complexa que es pot associar a tres dominis: cognitiu (\u201cTrobo dif\u00edcil plantejar objectius de futur\u201d), emocional (\u201cSento indifer\u00e8ncia per problemes que abans m\u2019interessaven\u201d) i de d\u00e8ficit d\u2019activaci\u00f3 autom\u00e0tica (“Necessito una empenta per comen\u00e7ar les coses”). “Distingir la configuraci\u00f3 de la mat\u00e8ria blanca associada a cada subtipus en HD pot permetre\u2019ns definir perfils de la malaltia a trav\u00e9s de l’espectre de l’apatia, facilitant el diagn\u00f2stic i el tractament de l’apatia”, afegeix Audrey DePaepe, estudiant Fullbright i primera autora de l\u2019 estudi.<\/p>\n
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“El nostre estudi planteja una metodologia nova i a mida, que utilitza mesures d’apatia espec\u00edfiques i un protocol optimitzat per estudiar la s\u00edndrome amb precisi\u00f3 i a la vegada considerar l’heterogene\u00eftat subjacent de la HD a nivell individual”, explica la Dra. Sierpowska.<\/p>\n
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Quaranta sis pacients amb la malaltia de Huntington i trenta-cinc controls sans es van sotmetre a una avaluaci\u00f3 psiqui\u00e0trica de l’apatia en els seus tres dominis, a m\u00e9s a m\u00e9s de diverses proves d\u2019imatge, per estudiar si les difer\u00e8ncies individuals dels tractes cortico-estriatals espec\u00edfics predien l’apatia global i els seus subdominis.\u00a0<\/p>\n
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Els investigadors van trobar que els perfils d\u2019apatia poden desenvolupar-se amb temporalitats diferents; per exemple, el domini de d\u00e8ficit d\u2019autoactivaci\u00f3 es manifesta abans que el motor. “Aquesta relaci\u00f3 \u00e9s molt rellevant per corroborar la naturalesa progressiva de l’apatia com a biomarcador en HD i el seu potencial per captar la progressi\u00f3 de la neurodegeneraci\u00f3”, explica la doctora C\u00e0mara. Aquests resultats tenen tamb\u00e9 implicacions en un diagn\u00f2stic diferencial de subtipus d’apatia i, posteriorment, en el disseny de tractaments farmacol\u00f2gics m\u00e9s individualitzats.<\/p>\n
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En l\u2019estudi han participat tamb\u00e9 diferents hospitals de Barcelona, com l\u2019Hospital Universitari de Bellvitge, l\u2019Hospital de la Santa Creu i Sant Pau, l\u2019Hospital Cl\u00ednic de Barcelona i l\u2019Hospital Mare de D\u00e9u de la Merc\u00e8. Aix\u00f2 ha perm\u00e8s investigar amb una mostra de pacients gran, fet d\u2019especial import\u00e0ncia en una malaltia minorit\u00e0ria com \u00e9s la malaltia de Huntington.<\/p>\n","protected":false},"excerpt":{"rendered":"
Investigadors IDIBELL-UB associen modificacions en la connectivitat en la mat\u00e8ria blanca a diferents subtipus d\u2019apatia, una de les s\u00edndromes psiqui\u00e0triques m\u00e9s comunes en la malaltia de Huntington (HD).<\/p>\n","protected":false},"author":6,"featured_media":10454,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[368,340],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-08 08:28:00","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7434"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=7434"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7434\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/10454"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=7434"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=7434"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=7434"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}