El 2018, al m\u00f3n es van produir 1,7 milions de morts per c\u00e0ncer de pulm\u00f3 (l’equivalent a la poblaci\u00f3 de la ciutat de Barcelona). L’alta taxa de mortalitat dels pacients amb c\u00e0ncer de pulm\u00f3 reflecteix la necessitat de desenvolupar noves ter\u00e0pies m\u00e9s eficaces.<\/p>\n
Un estudi, liderat pel Dr. \u00c1ngel R. Nebreda, investigador de l’Institut de Recerca Biom\u00e8dica (IRB), en el que han col\u00b7laborat el Dr. Mariano Barbacid del Centre Nacional d\u2019Investigacions Oncol\u00f2giques (CNIO) i el Dr. Alberto Villanueva del programa del IDIBELL ONCOBELL (ProCure-ICO), i que s\u2019ha publicat en la revista PNAS. Demostra que la prote\u00efna p38 \u00e9s un dels pilars en els quals se sustenten les c\u00e8l\u00b7lules tumorals de pulm\u00f3. En concret, el treball se centra en c\u00e8l\u00b7lules que expressen l’oncog\u00e8n Kras, causant de la transformaci\u00f3 d’una c\u00e8l\u00b7lula sana en una c\u00e8l\u00b7lula tumoral i les mutacions del qual s\u00f3n les responsables del 25% dels casos de c\u00e0ncer de pulm\u00f3.<\/p>\n
La import\u00e0ncia d’aquest treball \u00e9s que “mostra com els tumors s’aprofiten, per a la seva progressi\u00f3, d’una prote\u00efna que en principi protegia les c\u00e8l\u00b7lules sanes del pulm\u00f3”, assenyala\u00a0 Jessica Vitos, primera autora de l’article. El resultat de l’estudi pot tenir aplicaci\u00f3 terap\u00e8utica, “ja que els compostos qu\u00edmics que inhibeixin la funci\u00f3 de p38 interferirien amb el creixement dels tumors de pulm\u00f3”, continua.<\/p>\n
L’estudi ha comptat amb finan\u00e7ament del Consell Europeu de Recerca (ERC), el Ministeri de Ci\u00e8ncia, Innovaci\u00f3 i Universitats, l’Ag\u00e8ncia de Gesti\u00f3 d’Ajuts Universitaris (AGAUR) i de Recerca de la Generalitat de Catalunya i la Fundaci\u00f3 BBVA.<\/p>\n","protected":false},"excerpt":{"rendered":"
El 2018, al m\u00f3n es van produir 1,7 milions de morts per c\u00e0ncer de pulm\u00f3 (l’equivalent a la poblaci\u00f3 de la ciutat de Barcelona). L’alta taxa de mortalitat dels pacients amb c\u00e0ncer de pulm\u00f3 reflecteix la necessitat de desenvolupar noves ter\u00e0pies m\u00e9s eficaces. Un estudi, liderat pel Dr. \u00c1ngel R. Nebreda, investigador de l’Institut de […]<\/p>\n","protected":false},"author":6,"featured_media":10393,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"full-width-container","site-content-style":"unboxed","site-sidebar-style":"unboxed","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[332,447,346],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-10 21:19:46","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7357"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=7357"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7357\/revisions"}],"predecessor-version":[{"id":24628,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7357\/revisions\/24628"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/10393"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=7357"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=7357"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=7357"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}