El grup del Dr. Oscar M. Tirado del IDIBELL ha identificat LOXL2 com una pe\u00e7a clau en la capacitat metast\u00e0tica dels tumors en el Rabdomiosarcoma alveolar. LOXL2 actuaria dins les c\u00e8l\u00b7lules promovent la migraci\u00f3 i la invasi\u00f3 d\u2019aquestes, el que faria augmentar la capacitat metast\u00e0tica dels tumors, i per tant, obtenir un pitjor pron\u00f2stic dels pacients. El treball aporta informaci\u00f3 molt valuosa pel disseny de nous f\u00e0rmacs contra aquest tipus de tumors.<\/p>\n
El Rabdomiosarcoma \u00e9s el c\u00e0ncer infantil m\u00e9s freq\u00fcent en els teixits que anomenem parts toves, originant-se principalment en els m\u00fasculs del cos. Representa gaireb\u00e9 el 5% dels tumors pedi\u00e0trics i la seva taxa de superviv\u00e8ncia es troba entre el 60% i el 70%. El treball publicat a la revista \u201cCancer Letters\u201d se centra en el tipus m\u00e9s agressiu i dif\u00edcil de tractar d\u2019aquests tumors, el rabdomiosarcoma alveolar. La met\u00e0stasi juga un paper clau en el desenvolupament de la malaltia, ja que la seva aparici\u00f3 implica una caiguda dr\u00e0stica de la superviv\u00e8ncia dels pacients, que no supera el 30%. El grup del Dr. Oscar M. Tirado de l\u2019Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) ha observat que les c\u00e8l\u00b7lules d\u2019aquest tipus de sarcoma tenen nivells molt alts de la prote\u00efna LOXL2, i que a m\u00e9s, aquesta est\u00e0 implicada en la capacitat metast\u00e0tica dels tumors.<\/p>\n
En una situaci\u00f3 normal, la prote\u00efna LOXL2 actua fora de la c\u00e8l\u00b7lula modificant la matriu extracel\u00b7lular que l\u2019envolta. Tanmateix, en una ambient tumoral, LOXL2 promou la met\u00e0stasi des de l\u2019interior de les c\u00e8l\u00b7lules i per un mecanisme alternatiu a la seva activitat normal. La Dra. Olga Almacellas, primera autora de l\u2019estudi, afirma que en possibles futurs tractaments que inhibeixin LOXL2 per reduir la met\u00e0stasi en Rabdomiosarcoma, s\u2019haur\u00e0 de tenir en compte la penetraci\u00f3 dels f\u00e0rmacs a l\u2019interior de les c\u00e8l\u00b7lules. A m\u00e9s, afegeix, els f\u00e0rmacs ja existents que bloquegen la funci\u00f3 cl\u00e0ssica de LOXL2 no tindran cap efecte en el seu rol metast\u00e0tic, ja que \u00e9s independent d\u2019aquesta funci\u00f3.<\/p>\n
No solament els models cel\u00b7lulars de rabdomiosarcoma alveolar mostraven una clara disminuci\u00f3 de la capacitat metast\u00e0tica a l\u2019eliminar LOXL2, sin\u00f3 que tamb\u00e9, a l\u2019injectar aquestes c\u00e8l\u00b7lules a ratolins sans, les que expressaven LOXL2 formaven m\u00e9s met\u00e0stasis que les que no. D\u2019altra banda, mostres de pacients provinents de l\u2019Hospital Universitario Virgen del Roc\u00edo suggerien una menor superviv\u00e8ncia dels pacients que tenien nivells m\u00e9s alts de LOXL2. Tanmateix, un estudi m\u00e9s ampli amb m\u00e9s mostres seria necessari per a confirmar aquesta relaci\u00f3.<\/p>\n
Un dels interrogants que queda obert \u00e9s com LOXL2 regula la funci\u00f3 metast\u00e0tica en les c\u00e8l\u00b7lules tumorals. Els investigadors han vist que interacciona amb Vimentina, una prote\u00efna del citoesquelet que dona suport estructural i resist\u00e8ncia a les c\u00e8l\u00b7lules, i que, a m\u00e9s, t\u00e9 un paper crucial en la migraci\u00f3 cel\u00b7lular, un proc\u00e9s b\u00e0sic per a la met\u00e0stasi.<\/p>\n
Aquest estudi ha estat finan\u00e7at en part per Fundaci\u00f3n Alba P\u00e9rez lucha contra el c\u00e1ncer infantil, Instituto de Salud Carlos III, EU\u2019s Fondo Europeo de Desarrollo Regional (FEDER) i CERCA Program \/ Generalitat de Catalunya (2017SGR332).<\/p>\n","protected":false},"excerpt":{"rendered":"
El grup del Dr. Oscar M. Tirado del IDIBELL ha identificat LOXL2 com una pe\u00e7a clau en la capacitat metast\u00e0tica dels tumors en el Rabdomiosarcoma alveolar. LOXL2 actuaria dins les c\u00e8l\u00b7lules promovent la migraci\u00f3 i la invasi\u00f3 d\u2019aquestes, el que faria augmentar la capacitat metast\u00e0tica dels tumors, i per tant, obtenir un pitjor pron\u00f2stic dels […]<\/p>\n","protected":false},"author":6,"featured_media":10390,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"full-width-container","site-content-style":"unboxed","site-sidebar-style":"unboxed","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[332,447,398],"tags":[],"class_list":["post-7353","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cancer","category-p-de-mecanismes-molelculars-i-terapia-experimental-en-oncologia-oncobell","category-sarcoma"],"publishpress_future_action":{"enabled":false,"date":"2025-01-25 06:55:13","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7353","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=7353"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7353\/revisions"}],"predecessor-version":[{"id":24626,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7353\/revisions\/24626"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/10390"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=7353"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=7353"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=7353"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}