La malaltia d’Alzheimer d’inici tard\u00e0 (LOAD), \u00e9s a dir, la que apareix m\u00e9s enll\u00e0 dels 65 anys, \u00e9s la forma m\u00e9s freq\u00fcent d’aquesta malaltia neurodegenerativa, suposa m\u00e9s del 90% dels casos. Els primers canvis cerebrals associats a la malaltia poden apar\u00e8ixer anys abans que els primers s\u00edmptomes siguin evidents, per\u00f2 la falta de marcadors de risc clars dificulta que es posin en marxa estrat\u00e8gies de prevenci\u00f3 adequades per a usuaris amb major vulnerabilitat.<\/p>\n
Ara un estudi, publicat a la revista Journal of Psychiatric Research, ha proporcionat la primera evid\u00e8ncia que una connexi\u00f3 neuronal deficient entre el tronc de l’enc\u00e8fal i el cerebel pot ser predictiva del risc de desenvolupar Alzheimer. L’article compta amb la participaci\u00f3 d’investigadors de l’Institut d’Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) i del Consorci d’Investigaci\u00f3 Biom\u00e8dica en Xarxa de Salut Mental (CIBERSAM), la Universitat de Barcelona i l\u2019Hospital Universitari de Bellvitge, en col\u00b7laboraci\u00f3 amb investigadors del centre FLENI de Buenos Aires (Argentina) i del Consorci d’Investigaci\u00f3 Biom\u00e8dica en Xarxa de Malalties Neurodegeneratives (CIBERNED).<\/p>\n
Tot i que el component hereditari de la LOAD \u00e9s molt menor que el de la forma primerenca de la malaltia, tenir antecedents familiars d’Alzheimer d’inici tard\u00e0 incrementa lleugerament el risc de patir la malaltia. Per tant, l’estudi se centra en un grup de fills de pacients amb malaltia d’Alzheimer d’inici tard\u00e0 per mirar de trobar marcadors de risc primerencs. Els individus, en bon estat de salut i amb una edat mitjana de 50 anys, van mostrar un pitjor rendiment en tests de mem\u00f2ria, encara que dins de la franja de la normalitat, en comparaci\u00f3 amb voluntaris sense hist\u00f2ria familiar d’Alzheimer.<\/p>\n
Els investigadors van descobrir, despr\u00e9s de realitzar una prova de neuroimatge funcional, que aquesta ‘pitjor mem\u00f2ria’ s’associava al funcionament d’un circuit cerebral que connecta una regi\u00f3 del tronc encef\u00e0lic coneguda com a Locus Coeruleus amb el cerebel. Una estructura tradicionalment relacionada amb el control de l’equilibri i altres conductes motores, per\u00f2 que recentment s’ha associat tamb\u00e9 amb la capacitat de recordar a llarg termini.<\/p>\n
Aquest circuit cerebral s’estableix com una base neurobiol\u00f2gica de d\u00e8ficits neurocognitius primerencs i subtils, i el seu estudi podria identificar aquells subjectes amb un major risc de desenvolupar la malaltia d’Alzheimer en edats avan\u00e7ades. Igualment, el desenvolupament d’intervencions i estrat\u00e8gies terap\u00e8utiques que potenci\u00efn la connectivitat entre el Locus Coeruleus i el cerebel podria, en un futur, retardar l’edat d’aparici\u00f3 dels s\u00edmptomes o ajudar a minimitzar el seu impacte i alentir la seva progressi\u00f3. Aix\u00f2 obre la porta a estudis en qu\u00e8 \u00abseria d’inter\u00e8s determinar de quina manera l’adopci\u00f3 d’h\u00e0bits de vida saludables (com els bons h\u00e0bits diet\u00e8tics, eliminar el tabaquisme, o fer exercici f\u00edsic moderat) podria modular l’activitat d’aquest circuit cerebral\u00bb, en paraules de Carles Soriano-Mas, autor de correspond\u00e8ncia de l’article.<\/p>\n","protected":false},"excerpt":{"rendered":"
Investigadors de l’IDIBELL i CIBERSAM han descobert que alteracions en la connectivitat entre dues regions del cervell podrien ser un possible biomarcador de vulnerabilitat en l’Alzheimer.<\/p>\n","protected":false},"author":6,"featured_media":24634,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"full-width-container","site-content-style":"unboxed","site-sidebar-style":"unboxed","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[340,429],"tags":[],"class_list":["post-7346","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-neurociencies","category-psiquiatria-i-salut-mental"],"publishpress_future_action":{"enabled":false,"date":"2024-12-02 14:10:19","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7346","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=7346"}],"version-history":[{"count":1,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7346\/revisions"}],"predecessor-version":[{"id":24633,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7346\/revisions\/24633"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/24634"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=7346"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=7346"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=7346"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}