Colonbiome<\/a>. Aquest gran projecte t\u00e9 per objectiu buscar marcadors de la microbiota que puguin servir per a la detecci\u00f3 preco\u00e7 del c\u00e0ncer de c\u00f2lon. Per fer-ho, es recolliran bi\u00f2psies de c\u00f2lon i mostres de femta de pacients sans i pacients amb diferents fases de c\u00e0ncer colorectal, despr\u00e9s se\u2019n seq\u00fcenciar\u00e0 el genoma de la microbiota per identificar les difer\u00e8ncies entre els grups.<\/p>\n <\/p>\n
Dades a l\u2019abast de tothom<\/h4>\n
<\/p>\n
Totes les dades obtingudes en aquest estudi pilot han estat introdu\u00efdes en la European Nucleotide Archive, una base de dades p\u00fablica i col\u00b7laborativa, on es comparteixen seq\u00fc\u00e8ncies gen\u00f2miques de tota mena per a l\u2019aprofitament de tota la comunitat cient\u00edfica. A m\u00e9s, tots els resultats d\u2019aquesta primera prova pilot han estat publicats a la revista Scientific Data, revista tamb\u00e9 p\u00fablica, on s\u2019hi han detallat tant les seq\u00fc\u00e8ncies com les f\u00f3rmules d\u2019an\u00e0lisi bioinform\u00e0tic utilitzades.<\/p>\n
Aquest estudi no nom\u00e9s pret\u00e9n ser \u00fatil per als futurs treballs del grup, sin\u00f3 que gr\u00e0cies al seu car\u00e0cter obert i p\u00fablic pret\u00e9n ser una ajuda a tots aquells grups de recerca que estiguin realitzant an\u00e0lisis similars o provant noves eines bioinform\u00e0tiques, als quals se\u2019ls posa a l\u2019abast tots els resultats obtinguts. A m\u00e9s, els investigadors asseguren que tamb\u00e9 faran p\u00fablics tots els detalls dels estudis posteriors, per aix\u00ed seguir contribuint en la col\u00b7laboraci\u00f3 i l\u2019aven\u00e7 del camp.<\/p>\n
<\/p>\n
Els dos m\u00e8todes de seq\u00fcenciaci\u00f3<\/h4>\n
<\/p>\n
En l\u2019estudi s\u2019han comparat dos m\u00e8todes de seq\u00fcenciaci\u00f3: el 16s i el Shotgun. El primer desxifra la seq\u00fc\u00e8ncia d\u2019un sol gen dels microorganismes, mentre que el segon ens dona la seq\u00fc\u00e8ncia completa de tot el genoma. Tot i que en seq\u00fcenciar un \u00fanic gen perdem resoluci\u00f3, pot resultar m\u00e9s econ\u00f2mic. A m\u00e9s, el fet de seq\u00fcenciar un gen nom\u00e9s present en la microbiota ens permet analitzar mostres de bi\u00f2psies sense que el genoma hum\u00e0 hi interfereixi.<\/p>\n
Addicionalment, la prova pilot ha mostrat que ambdues t\u00e8cniques s\u00f3n consistents. Tot i que la seq\u00fcenciaci\u00f3 completa \u00e9s m\u00e9s sensible i hi distingim m\u00e9s esp\u00e8cies de microorganismes, en cap moment contradiu els resultats obtinguts en seq\u00fcenciar un \u00fanic gen.<\/p>\n","protected":false},"excerpt":{"rendered":"
En aquest estudi pilot s\u2019han comparat dos m\u00e8todes de seq\u00fcenciaci\u00f3, utilitzant mostres de bi\u00f2psies de c\u00f2lon i mostres de femta de nou pacients. Tamb\u00e9 s\u2019han definit els m\u00e8todes d\u2019an\u00e0lisi bioinform\u00e0tic m\u00e9s adients per a aquest tipus d\u2019estudis.<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[332,375],"tags":[],"class_list":["post-7319","post","type-post","status-publish","format-standard","hentry","category-cancer","category-colorectal"],"publishpress_future_action":{"enabled":false,"date":"2024-11-29 12:23:45","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7319","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=7319"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7319\/revisions"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=7319"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=7319"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=7319"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}