Un estudi de l\u2019IDIBELL, l\u2019Hospital de Bellvitge i l\u2019Institut d\u2019Investigaci\u00f3 contra la Leuc\u00e8mia Josep Carreras i l\u2019Hospital Infantil Meyer de Flor\u00e8ncia ha descobert un mecanisme clau relacionat amb la recuperaci\u00f3 de la funci\u00f3 del rony\u00f3 despr\u00e9s d\u2019un trasplantament. En concret, l\u2019estudi ha descrit una causa per la qual les c\u00e8l\u00b7lules progenitores renals de vegades no poden reparar els teixits danyats durant un trasplantament.<\/p>\n
L\u2019estudi, publicat a American Journal of Transplantation<\/em>, la revista de major impacte en trasplantament, aporta un important coneixement per ajudar a trobar nous tractaments que previnguin la necessitat de fer di\u00e0lisi despr\u00e9s d\u2019un trasplantament, el que es coneix com a funci\u00f3 retardada de l\u2019empelt renal<\/em>. Es tracta d\u2019una complicaci\u00f3 freq\u00fcent, que no t\u00e9 tractament i que afecta al voltant d\u2019un de cada 3 trasplantaments. A m\u00e9s, t\u00e9 unes conseq\u00fc\u00e8ncies negatives en termes de m\u00e9s dies d\u2019hospitalitzaci\u00f3, augment del risc de rebuig agut i reducci\u00f3 de la durada del rony\u00f3 trasplantat.<\/p>\n Sempre que es trasplanta un \u00f2rgan com ara un rony\u00f3, es produeix en alguna mesura un dany anomenat lesi\u00f3 per isqu\u00e8mia i reperfusi\u00f3<\/em>. Aquest dany deriva, entre d\u2019altres factors, de les caracter\u00edstiques del donant i del temps que el rony\u00f3 est\u00e0 preservat en fred, i acostuma a ser reparat a partir de l\u2019activitat de les anomenades c\u00e8l\u00b7lules progenitores renals<\/em>, les quals tenen la propietat de poder dividir-se i convertir-se en altres tipus de c\u00e8l\u00b7lules. Aquest pioner estudi ha descobert que la mateixa lesi\u00f3 d\u2019isqu\u00e8mia i reperfusi\u00f3, quan \u00e9s prou greu, provoca canvis epigen\u00e8tics en les c\u00e8l\u00b7lules progenitores renals que afecten negativament la seva acci\u00f3 reparadora. Aix\u00ed mateix, l\u2019estudi ha identificat un gen anomenat LHX1 com un protagonista principal d\u2019aquesta afectaci\u00f3.<\/p>\n Per arribar a aquestes conclusions, l\u2019estudi ha portat a terme l\u2019an\u00e0lisi epigen\u00e8tica de tot el genoma de c\u00e8l\u00b7lules progenitores a\u00efllades de l\u2019orina i ronyons de donants i trasplantats renals. Aix\u00ed mateix, l\u2019estudi ha incl\u00f2s treballs amb ratolins i estudis funcionals.<\/p>\n El treball ha estat liderat pel Dr. Josep M. Cruzado, cap del Servei de Nefrologia de l\u2019Hospital Universitari de Bellvitge i del Grup de Recerca en Nefrologia i Trasplantament Renal de l\u2019IDIBELL, i la Dra. Mar\u00eda Berdasco, l\u00edder del Grup de Recerca en Ter\u00e0pies Epigen\u00e8tiques de l\u2019Institut de Recerca contra la Leuc\u00e8mia Josep Carreras.<\/p>\n Segons destaca el Dr. Cruzado, \u201caquesta investigaci\u00f3 s\u2019inscriu en una l\u00ednia de recerca que no pret\u00e9n evitar directament el dany dels teixits, sin\u00f3 protegir i potenciar l\u2019acci\u00f3 de les c\u00e8l\u00b7lules encarregades de reparar aquests danys\u201d. En la mateixa l\u00ednia, la Dra. Berdasco subratlla que l\u2019estudi \u201cobre noves perspectives perqu\u00e8 puguem arribar a desenvolupar ter\u00e0pies epigen\u00e8tiques que puguin prevenir de manera molt efectiva un frac\u00e0s renal despr\u00e9s del trasplantament\u201d.<\/p>\n <\/p>\n <\/p>\n L\u2019Institut d’Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) \u00e9s un centre de recerca en biomedicina creat l\u2019any 2004. Est\u00e0 participat per l’Hospital Universitari de Bellvitge i l\u2019Hospital de Viladecans de l’Institut Catal\u00e0 de la Salut, l’Institut Catal\u00e0 d’Oncologia, la Universitat de Barcelona i l\u2019Ajuntament de l\u2019Hospitalet de Llobregat.<\/em><\/p>\n L\u2019IDIBELL \u00e9s membre del Campus d’Excel\u00b7l\u00e8ncia Internacional de la Universitat de Barcelona HUBc i forma part de la instituci\u00f3 CERCA de la Generalitat de Catalunya. L’any 2009 es va convertir en un dels cinc primers centres d\u2019investigaci\u00f3 espanyols acreditats com a institut d\u2019investigaci\u00f3 sanit\u00e0ria per l\u2019Instituto de Salud Carlos III. A m\u00e9s, forma part del programa \u201cHR Excellence in Research\u201d de la Uni\u00f3 Europea i \u00e9s membre de EATRIS i REGIC. Des de l\u2019any 2018, l\u2019IDIBELL \u00e9s un Centro Acreditado de la Fundaci\u00f3n Cient\u00edfica AECC (FCAECC).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":" Han descrit una causa per la qual les c\u00e8l\u00b7lules progenitores renals de vegades no poden reparar els teixits danyats
\nL\u2019estudi s\u2019ha publicat a American Journal of Transplantation, la revista de major impacte en trasplantament<\/p>\n","protected":false},"author":8,"featured_media":26790,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[334,339,479],"tags":[],"class_list":["post-26787","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicina-translacional","category-nefrologia-i-transplantament-renal","category-p-de-malalties-infeccioses-i-transplantaments"],"publishpress_future_action":{"enabled":false,"date":"2024-12-25 17:11:05","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/26787","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=26787"}],"version-history":[{"count":1,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/26787\/revisions"}],"predecessor-version":[{"id":26791,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/26787\/revisions\/26791"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/26790"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=26787"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=26787"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=26787"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}