{"id":26494,"date":"2024-11-13T10:44:46","date_gmt":"2024-11-13T09:44:46","guid":{"rendered":"https:\/\/idibell.cat\/?p=26494"},"modified":"2024-11-13T11:55:04","modified_gmt":"2024-11-13T10:55:04","slug":"aurora-pujol-rep-financament-de-la-convocatoria-caixaresearch-dinvestigacio-en-salut-2024","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2024\/11\/aurora-pujol-rep-financament-de-la-convocatoria-caixaresearch-dinvestigacio-en-salut-2024\/","title":{"rendered":"Aurora Pujol rep finan\u00e7ament de la convocat\u00f2ria CaixaResearch d\u2019Investigaci\u00f3 en Salut 2024"},"content":{"rendered":"

La convocat\u00f2ria CaixaResearch d\u2019Investigaci\u00f3 en Salut 2024 finan\u00e7ar\u00e0 un projecte de l\u2019IDIBELL liderat per la Dra. Aurora Pujol.\u00a0 La convocat\u00f2ria competitiva de la Fundaci\u00f3 \u201dla Caixa\u201d est\u00e0 dotada amb 25,7 milions d\u2019euros i premia projectes de recerca biom\u00e8dica d\u2019excel\u00b7l\u00e8ncia amb gran impacte social, seleccionats per experts internacionals de gran prestigi en els seus camps d\u2019estudi. Entre els guardonats d\u2019enguany hi ha 11 projectes liderats des de 6 centres de recerca catalans. L\u2019acte de lliurament dels ajuts tingu\u00e9 lloc ahir al CaixaForum Madrid.<\/span>\u00a0<\/span><\/p>\n

El projecte liderat per la Dra. Aurora Pujol, que ha rebut una subvenci\u00f3 de 999.782,47 euros, t\u00e9 per objectiu la <\/span>cerca d\u2019una cura per a una malaltia gen\u00e8tica degenerativa letal que afecta els infants, l\u2019adrenoleucodistr\u00f2fia. <\/span><\/b>La investigaci\u00f3 es dur\u00e0 a terme en consorci amb Manel Esteller, de l\u2019Institut de Recerca contra la Leuc\u00e8mia Josep Carreras, Antonella Consiglio, de l\u2019IDIBELL, la Universitat de Barcelona i l’IBUB (Institut de Biomedicina de la UB), i la Asociaci\u00f3n Espa\u00f1ola contra las Leucodistrofias.<\/p>\n

L\u2019adrenoleucodistr\u00f2fia \u00e9s una malaltia neurometab\u00f2lica heredit\u00e0ria poc freq\u00fcent. Afecta 1 de cada 17.000 habitants, sobretot homes, tot i que algunes dones portadores poden patir formes m\u00e9s lleus de la malaltia. Est\u00e0 causada per mutacions del gen <\/span>ABCD1<\/span><\/i> i danya la mielina, la membrana que a\u00eflla les c\u00e8l\u00b7lules nervioses del cervell.\u00a0<\/span>\u00a0<\/span><\/p>\n

Hi ha diferents variants de la malaltia, amb diversos nivells de gravetat, que poden afectar diferents membres d\u2019una mateixa fam\u00edlia. La m\u00e9s greu \u00e9s l\u2019adrenoleucodistr\u00f2fia cerebral infantil, que \u00e9s degenerativa i letal i afecta infants d\u2019entre 5 i 10 anys d\u2019edat. Les variants m\u00e9s lleus s\u00f3n cr\u00f2niques. Malgrat aix\u00f2, no s\u2019acaben d\u2019entendre b\u00e9 els mecanismes moleculars que regulen la inflamaci\u00f3 cerebral i que donen lloc a formes m\u00e9s o menys greus de la malaltia.<\/span>\u00a0<\/span><\/p>\n

Mitjan\u00e7ant el projecte, els investigadors intentaran dilucidar les bases moleculars de la malaltia i identificar els factors que condueixen a la p\u00e8rdua de mielina. Per fer-ho, utilitzaran tecnologies capdavanteres i desenvoluparan nous models de la malaltia a partir del cultiu cel\u00b7lular de mostres de pacients amb les dues variants de la malaltia per identificar-ne els mecanismes moleculars i biomarcadors. Els resultats que s\u2019obtinguin en el projecte permetran millorar la comprensi\u00f3 i el maneig de la malaltia, aplanaran el cam\u00ed cap a futurs assaigs cl\u00ednics i facilitaran la implantaci\u00f3 del cribratge neonatal per a un diagn\u00f2stic preco\u00e7.<\/span><\/p>\n

 <\/p>\n

L\u2019Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) \u00e9s un centre de recerca en biomedicina creat l\u2019any 2004. Est\u00e0 participat per l\u2019Hospital Universitari de Bellvitge i l\u2019Hospital de Viladecans de l\u2019Institut Catal\u00e0 de la Salut, l\u2019Institut Catal\u00e0 d\u2019Oncologia, la Universitat de Barcelona i l\u2019Ajuntament de l\u2019Hospitalet de Llobregat.<\/em><\/p>\n

L\u2019IDIBELL \u00e9s membre del Campus d\u2019Excel\u00b7l\u00e8ncia Internacional de la Universitat de Barcelona HUBc i forma part de la instituci\u00f3 CERCA de la Generalitat de Catalunya. L\u2019any 2009 es va convertir en un dels cinc primers centres d\u2019investigaci\u00f3 espanyols acreditats com a institut d\u2019investigaci\u00f3 sanit\u00e0ria per l\u2019Instituto de Salud Carlos III. A m\u00e9s, forma part del programa \u201cHR Excellence in Research\u201d de la Uni\u00f3 Europea i \u00e9s membre de EATRIS i REGIC. Des de l\u2019any 2018, l\u2019IDIBELL \u00e9s un Centro Acreditado de la Fundaci\u00f3n Cient\u00edfica AECC (FCAECC).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

El projecte t\u00e9 per objectiu la cerca d\u2019una cura per a una malaltia gen\u00e8tica degenerativa letal que afecta els infants, l\u2019adrenoleucodistr\u00f2fia.<\/p>\n","protected":false},"author":8,"featured_media":26498,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[353,380,340,457],"tags":[],"class_list":["post-26494","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cellules-mare-i-malalties-neurodegeneratives","category-malalties-neurometaboliques","category-neurociencies","category-p-de-neurociencies"],"publishpress_future_action":{"enabled":false,"date":"2024-12-25 15:53:22","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/26494","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=26494"}],"version-history":[{"count":3,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/26494\/revisions"}],"predecessor-version":[{"id":26500,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/26494\/revisions\/26500"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/26498"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=26494"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=26494"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=26494"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}