{"id":24867,"date":"2024-01-12T10:01:51","date_gmt":"2024-01-12T09:01:51","guid":{"rendered":"https:\/\/idibell.cat\/?p=24867"},"modified":"2024-01-12T10:01:51","modified_gmt":"2024-01-12T09:01:51","slug":"presenten-un-virus-oncolitic-dirigit-a-cellules-nk-amb-gran-potencial-antitumoral","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2024\/01\/presenten-un-virus-oncolitic-dirigit-a-cellules-nk-amb-gran-potencial-antitumoral\/","title":{"rendered":"Presenten un virus oncol\u00edtic dirigit a c\u00e8l\u00b7lules NK amb gran potencial antitumoral"},"content":{"rendered":"<p>C\u00e8l\u00b7lules immunit\u00e0ries com els limf\u00f2cits T citot\u00f2xics (LTc) o les <em>natural killer<\/em> (NK) estan especialitzades en identificar c\u00e8l\u00b7lules tumorals i eliminar-les per tal de frenar el creixement de tumors, per\u00f2 les c\u00e8l\u00b7lules tumorals tenen eines per reprimir l\u2019activitat del sistema immunitari o camuflar-se\u2019n i aix\u00ed poder-se reproduir indefinidament. La immunoter\u00e0pia del c\u00e0ncer vol revertir aquesta immunosupressi\u00f3 i estimular l\u2019activitat de c\u00e8l\u00b7lules com els LTcs o les NKs per tal que puguin seguir identificant i eliminant les c\u00e8l\u00b7lules tumorals i, aix\u00ed, combatre la malaltia. Un tipus concret d\u2019immunoter\u00e0pia utilitza virus oncol\u00edtics, que infecten les c\u00e8l\u00b7lules canceroses per tal d\u2019eliminar-les directament o d\u2019atraure-hi la resposta immunit\u00e0ria.<\/p>\n<p>Ara, un grup de recerca de l\u2019IDIBELL i l\u2019ICO ha desenvolupat un virus oncol\u00edtic concret, ICOVIR15K-MICAMut, que, en penetrar a les c\u00e8l\u00b7lules tumorals i expressar-hi el seu material gen\u00e8tic, atrau i activa les c\u00e8l\u00b7lules NK. Al laboratori, els investigadors han comprovat, utilitzant ratolins com a model experimental, com aquest virus indu\u00efa una resposta immunit\u00e0ria antitumoral m\u00e9s eficient i un major control del creixement del c\u00e0ncer. Aquest resultat obre les portes a un futur assaig cl\u00ednic.<\/p>\n<p>Els resultats amb virus oncol\u00edtics s\u00f3n prometedors, per\u00f2 encara cal fer m\u00e9s recerca per tal de dissenyar un tractament robust capa\u00e7 d\u2019erradicar un tumor. En aquest sentit, el Dr. Rafael Moreno, l\u00edder de l\u2019estudi, assegura que aquest treball \u201cdestaca el paper de les c\u00e8l\u00b7lules NK en la immunoter\u00e0pia i presenta un enfocament innovador que t\u00e9 un gran potencial cl\u00ednic\u201d.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><em>L\u2019Institut d&#8217;Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) \u00e9s un centre de recerca en biomedicina creat l\u2019any 2004. Est\u00e0 participat per l&#8217;Hospital Universitari de Bellvitge i l\u2019Hospital de Viladecans de l&#8217;Institut Catal\u00e0 de la Salut, l&#8217;Institut Catal\u00e0 d&#8217;Oncologia, la Universitat de Barcelona i l\u2019Ajuntament de l\u2019Hospitalet de Llobregat.<\/em><\/p>\n<p><em>L\u2019IDIBELL \u00e9s membre del Campus d&#8217;Excel\u00b7l\u00e8ncia Internacional de la Universitat de Barcelona HUBc i forma part de la instituci\u00f3 CERCA de la Generalitat de Catalunya. L&#8217;any 2009 es va convertir en un dels cinc primers centres d\u2019investigaci\u00f3 espanyols acreditats com a institut d\u2019investigaci\u00f3 sanit\u00e0ria per l\u2019Instituto de Salud Carlos III. A m\u00e9s, forma part del programa \u201cHR Excellence in Research\u201d de la Uni\u00f3 Europea i \u00e9s membre de EATRIS i REGIC. Des de l\u2019any 2018, l\u2019IDIBELL \u00e9s un Centro Acreditado de la Fundaci\u00f3n Cient\u00edfica AECC (FCAECC).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un grup de recerca de l\u2019IDIBELL i l\u2019ICO han presentat un virus oncol\u00edtic que estimula la resposta antitumoral de les c\u00e8l\u00b7lules NK i ajuda a frenar el creixement del c\u00e0ncer.<\/p>\n","protected":false},"author":8,"featured_media":24869,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[332,513,453,447,452,425],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-23 23:37:55","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/24867"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=24867"}],"version-history":[{"count":1,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/24867\/revisions"}],"predecessor-version":[{"id":24870,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/24867\/revisions\/24870"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/24869"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=24867"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=24867"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=24867"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}