Un estudi d’investigadors de la Universitat de Virginia, en col\u00b7laboraci\u00f3 amb especialistes de l\u2019IDIBELL, l\u2019HUB i l\u2019ICO, ofereix perspectives in\u00e8dites sobre els mecanismes moleculars que condueixen a la Telangiect\u00e0sia Hemorr\u00e0gica Heredit\u00e0ria (HHT), mitjan\u00e7ant la detecci\u00f3 d\u2019un mecanisme consistent en un recanvi cel\u00b7lular accelerat en aquestes malformacions vasculars. A m\u00e9s, la recerca fa pal\u00e8s que inhibint el mecanisme es pot prevenir el desenvolupament de les malformacions vasculars.<\/p>\n
Investigadors de Bellvitge han pogut aportar l’evid\u00e8ncia d’aquest nou mecanisme tamb\u00e9 en telangiect\u00e0sies cut\u00e0nies de pacients amb HHT. El coneixement ser\u00e0 de gran utilitat pels pacients amb HHT, aix\u00ed com per aquells amb malformacions vasculars d’altres afeccions, algunes tamb\u00e9 considerades malalties minorit\u00e0ries. La recerca traslacional ha estat la forma de treballar durant la investigaci\u00f3, en qu\u00e8 les preguntes cl\u00edniques s\u2019estudiaven en models cel\u00b7lulars o amb animals al laboratori per tal de retornar la informaci\u00f3 directament a l\u2019an\u00e0lisi amb pacients.<\/p>\n
La troballa s’ha publicat a la revista Circulation<\/em>, revista especialitzada en l’\u00e0rea cardiovascular, i en l’article hi han participat el Dr. Antoni Riera-Mestre, l\u00edder del grup de recerca en malalties sist\u00e8miques, vasculars i envelliment de l\u2019IDIBELL i l\u2019HUB, i el Dr. Pau Cerd\u00e0 Serra i la Dra. Agn\u00e8s Figueras, investigadors del Programa Oncobell de l\u2019IDIBELL i l\u2019ICO.<\/p>\n <\/p>\n Telangiect\u00e0sia Hemorr\u00e0gica Heredit\u00e0ria<\/strong><\/p>\n L\u2019HHT \u00e9s una malaltia minorit\u00e0ria que afecta una de cada 6.000 persones, causant-los malformacions vasculars, tant en capil\u00b7lars (denominades telangiect\u00e0sies), com en vasos de m\u00e9s calibre, sobretot a nivell pulmonar i hep\u00e0tic. La patologia, que en l’actualitat no t\u00e9 cura, t\u00e9 com a manifestaci\u00f3 cl\u00ednica m\u00e9s freq\u00fcent les hemorr\u00e0gies nasals de repetici\u00f3, per la pres\u00e8ncia de telangiect\u00e0sies a aquest nivell.<\/p>\n <\/p>\n <\/p>\n L\u2019Institut d’Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) \u00e9s un centre de recerca en biomedicina creat l\u2019any 2004. Est\u00e0 participat per l’Hospital Universitari de Bellvitge i l\u2019Hospital de Viladecans de l’Institut Catal\u00e0 de la Salut, l’Institut Catal\u00e0 d’Oncologia, la Universitat de Barcelona i l\u2019Ajuntament de l\u2019Hospitalet de Llobregat.<\/em><\/p>\n L\u2019IDIBELL \u00e9s membre del Campus d’Excel\u00b7l\u00e8ncia Internacional de la Universitat de Barcelona HUBc i forma part de la instituci\u00f3 CERCA de la Generalitat de Catalunya. L’any 2009 es va convertir en un dels cinc primers centres d\u2019investigaci\u00f3 espanyols acreditats com a institut d\u2019investigaci\u00f3 sanit\u00e0ria per l\u2019Instituto de Salud Carlos III. A m\u00e9s, forma part del programa \u201cHR Excellence in Research\u201d de la Uni\u00f3 Europea i \u00e9s membre de EATRIS i REGIC. Des de l\u2019any 2018, l\u2019IDIBELL \u00e9s un Centro Acreditado de la Fundaci\u00f3n Cient\u00edfica AECC (FCAECC).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":" Un estudi publicat a Circulation ofereix perspectives in\u00e8dites sobre els mecanismes moleculars que condueixen a la Telangiect\u00e0sia Hemorr\u00e0gica Heredit\u00e0ria.<\/p>\n","protected":false},"author":8,"featured_media":24859,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[332,427,334,466,447,425],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-18 12:54:33","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/24858"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=24858"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/24858\/revisions"}],"predecessor-version":[{"id":24861,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/24858\/revisions\/24861"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/24859"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=24858"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=24858"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=24858"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}