Un grup de recerca multidisciplinari format per professionals de l\u2019IDIBELL, l\u2019Hospital Universitari de Bellvitge i l\u2019Institut Catal\u00e0 d\u2019Oncologia ha evaluat l\u2019\u00fas d\u2019una plataforma de seq\u00fcenciaci\u00f3 massiva per trobar mutacions que predisposin a desenvolupar certs tipus de tumors o que ajudin a escollir ter\u00e0pies dirigides per a cada pacient. L\u2019estudi ha estat publicat a ESMO Open i \u00e9s el primer treball del Comit\u00e8 Molecular de Tumors i del Laboratori Core d\u2019An\u00e0lisi Molecular del Campus de Bellvitge, en qu\u00e8 participen conjuntament pat\u00f2legs, onc\u00f2legs, bi\u00f2legs, farmac\u00e8utics, genetistes i bioinform\u00e0tics de les tres institucions.<\/p>\n
En aquesta primera avaluaci\u00f3, s\u2019han analitzat 200 pacients amb c\u00e0ncer de pulm\u00f3 i s\u2019han detectat alteracions potencialment tractables en un 26,5% dels casos. S\u2019observa tamb\u00e9 que hi ha una major superviv\u00e8ncia en aquells malalts en qu\u00e8 es detecta una diana terap\u00e8utica i que rebien la ter\u00e0pia dirigida adient, comparat amb els que no la rebien o amb els pacients que no presentaven cap diana. Actualment, \u00e9s fonamental dur a terme un estudi molecular massiu per poder definir el tractament m\u00e9s \u00f2ptim pels pacients amb c\u00e0ncer de pulm\u00f3.<\/p>\n
<\/p>\n
La seq\u00fcenciaci\u00f3 massiva<\/strong><\/p>\n Aquesta plataforma de seq\u00fcenciaci\u00f3 massiva NGS permet identificar alteracions a l\u2019ADN i l\u2019ARN de m\u00e9s de 500 gens i tamb\u00e9 avaluar altres tipus de marcadors gen\u00e8tics com poden ser la inestabilitat de microsat\u00e8l\u00b7lits o la c\u00e0rrega mutacional tumoral, els quals s\u00f3n de gran utilitat per predir l\u2019efic\u00e0cia de la immunoter\u00e0pia. A m\u00e9s d’estudiar els gens m\u00e9s rellevants en la rutina cl\u00ednica oncol\u00f2gica, tamb\u00e9 permet analitzar altres gens associats a la susceptibilitat a desenvolupar un tumor o alteracions moleculars que poden ser tribut\u00e0ries de ter\u00e0pies experimentals, fet que pot beneficiar als pacients i facilitar l’acc\u00e9s a noves estrat\u00e8gies terap\u00e8utiques.<\/p>\n","protected":false},"excerpt":{"rendered":" L\u2019\u00fas d\u2019aquesta plataforma de seq\u00fcenciaci\u00f3 gen\u00e8tica massiva podria millorar la superviv\u00e8ncia dels pacients gr\u00e0cies a la detecci\u00f3 de dianes terap\u00e8utiques i de mutacions que predisposen al c\u00e0ncer.<\/p>\n","protected":false},"author":8,"featured_media":24811,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[332,417,446,447,333],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-23 20:15:48","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/24810"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=24810"}],"version-history":[{"count":1,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/24810\/revisions"}],"predecessor-version":[{"id":24812,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/24810\/revisions\/24812"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/24811"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=24810"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=24810"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=24810"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}