{"id":24784,"date":"2023-12-19T12:50:06","date_gmt":"2023-12-19T11:50:06","guid":{"rendered":"https:\/\/idibell.cat\/?p=24784"},"modified":"2023-12-19T12:50:06","modified_gmt":"2023-12-19T11:50:06","slug":"sobre-una-nova-via-per-combatre-el-cancer-a-traves-del-gen-myc","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2023\/12\/sobre-una-nova-via-per-combatre-el-cancer-a-traves-del-gen-myc\/","title":{"rendered":"S\u2019obre una nova via per combatre el c\u00e0ncer a trav\u00e9s del gen MYC"},"content":{"rendered":"<p>Un estudi internacional en el que ha participat l&#8217;investigador de l\u2019IDIBELL i l\u2019ICO, Miquel \u00c0ngel Pujana, i que ha estat publicat a la revista cient\u00edfica <em>Cancer Research<\/em> obre una nova via pel tractament contra el c\u00e0ncer, sobretot els causats per l\u2019activitat desregulada d\u2019un gen anomenat MYC.\u00a0 Aquest gen es troba sobre-activat en un alt percentatge de tumors i, d\u2019aquesta manera, promou el desenvolupament i la progressi\u00f3 del c\u00e0ncer. De fet, es considera un oncogen i encara no existeixen ter\u00e0pies dirigides contra la seva activitat.<\/p>\n<p><strong>Com actua aquest gen per promoure la malaltia?<\/strong><\/p>\n<p>Com que atacar directament al MYC resulta molt complicat, l\u2019equip d\u2019investigadors\/es que ha\u00a0 participat en aquest estudi han buscat una altra estrat\u00e8gia. Han identificat prote\u00efnes que s\u00f3n necess\u00e0ries per tal de que el gen MYC promogui el desenvolupament del tumor. Per fer-ho, han utilitzat una eina gen\u00e8tica anomenada CRISPR per veure quins components s\u00f3n cr\u00edtics en les accions de MYC en el c\u00e0ncer de mama i han descobert una prote\u00efna, anomenada R-Loops, que pot causar canvis en l\u2019activitat de MYC, i una altra prote\u00efna, anomenada Topoisomerasa 1 (TOP1), que regula l\u2019anterior.<\/p>\n<p>Aix\u00ed doncs, quan han desactivat TOP1, en les c\u00e8l\u00b7lules cancer\u00edgenes gr\u00e0cies al MYC, s\u2019ha pogut observar que les c\u00e8l\u00b7lules perdien la seva habilitat per a cr\u00e9ixer i dividir-se i, per tant, s\u2019ha trobat una debilitat espec\u00edfica. Aquest proc\u00e9s s\u2019ha pogut verificar en models de tumors en animals i els resultats han demostrat la seva efectivitat. Pel Dr Pujana, \u201caquest estudi obre una nova oportunitat de tractament dirigit contra una elevada proporci\u00f3 de tumors\u201d.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><em>L\u2019Institut d&#8217;Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) \u00e9s un centre de recerca en biomedicina creat l\u2019any 2004. Est\u00e0 participat per l&#8217;Hospital Universitari de Bellvitge i l\u2019Hospital de Viladecans de l&#8217;Institut Catal\u00e0 de la Salut, l&#8217;Institut Catal\u00e0 d&#8217;Oncologia, la Universitat de Barcelona i l\u2019Ajuntament de l\u2019Hospitalet de Llobregat.<\/em><\/p>\n<p><em>L\u2019IDIBELL \u00e9s membre del Campus d&#8217;Excel\u00b7l\u00e8ncia Internacional de la Universitat de Barcelona HUBc i forma part de la instituci\u00f3 CERCA de la Generalitat de Catalunya. L&#8217;any 2009 es va convertir en un dels cinc primers centres d\u2019investigaci\u00f3 espanyols acreditats com a institut d\u2019investigaci\u00f3 sanit\u00e0ria per l\u2019Instituto de Salud Carlos III. A m\u00e9s, forma part del programa \u201cHR Excellence in Research\u201d de la Uni\u00f3 Europea i \u00e9s membre de EATRIS i REGIC. Des de l\u2019any 2018, l\u2019IDIBELL \u00e9s un Centro Acreditado de la Fundaci\u00f3n Cient\u00edfica AECC (FCAECC).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un equip d\u2019investigadors internacionals ha identificat els processos espec\u00edfics a trav\u00e9s dels quals l\u2019oncogen MYC promou la malaltia i, d\u2019aquesta manera, demostrar que aquest gen pot atacar debilitats espec\u00edfiques de les c\u00e8l\u00b7lules tumorals.<\/p>\n","protected":false},"author":8,"featured_media":24788,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[332,390,447,452],"tags":[],"class_list":["post-24784","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cancer","category-cancer-de-mama","category-p-de-mecanismes-molelculars-i-terapia-experimental-en-oncologia-oncobell","category-procure"],"publishpress_future_action":{"enabled":false,"date":"2024-12-29 08:02:06","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/24784","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=24784"}],"version-history":[{"count":1,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/24784\/revisions"}],"predecessor-version":[{"id":24789,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/24784\/revisions\/24789"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/24788"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=24784"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=24784"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=24784"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}