{"id":24617,"date":"2023-11-23T12:29:41","date_gmt":"2023-11-23T11:29:41","guid":{"rendered":"https:\/\/idibell.cat\/?p=24617"},"modified":"2023-11-23T12:33:16","modified_gmt":"2023-11-23T11:33:16","slug":"un-estudi-de-lidibell-lico-i-ligtp-posa-la-medicina-de-precisio-al-servei-dels-tumors-nerviosos","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2023\/11\/un-estudi-de-lidibell-lico-i-ligtp-posa-la-medicina-de-precisio-al-servei-dels-tumors-nerviosos\/","title":{"rendered":"Un estudi de l\u2019IDIBELL, l\u2019ICO i l\u2019IGTP posa la medicina de precisi\u00f3 al servei dels tumors nerviosos"},"content":{"rendered":"<p>Un equip de recerca, liderat per la Dra. Conxi L\u00e1zaro cap del <a href=\"https:\/\/idibell.cat\/recerca\/area-de-cancer\/programa-de-mecanismes-molleculars-i-terapia-experimental-en-oncologia-oncobell\/cancer-hereditari\/\">grup de c\u00e0ncer hereditari<\/a> de l\u2019IDIBELL i l\u2019Institut Catal\u00e0 d\u2019Oncologia (ICO), i el Dr. Eduard Serra, de l\u2019Institut de Recerca Germans Trias i Pujol (IGTP), ha <a href=\"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1002\/1878-0261.13534\">publicat a la revista Molecular Oncology<\/a> l\u2019ampliaci\u00f3 d\u2019una plataforma de medicina de precisi\u00f3 per analitzar i millorar els tractaments dels tumors malignes de la beina nerviosa perif\u00e8rica (MPNSTs, per les seves sigles en angl\u00e8s). Aquests tumors, s\u00f3n coneguts per la seva agressivitat i tenen una taxa de superviv\u00e8ncia baixa, especialment en pacients amb un trastorn gen\u00e8tic anomenat neurofibromatosi tipus 1 (NF1), una malaltia heredit\u00e0ria que afecta aproximadament a 1 de cada 3.000 persones. Representen entre el 3 i el 10% de tots els tumors de teixits tous o sarcomes en la poblaci\u00f3 general, mentre que tenen una prevalen\u00e7a que oscil\u00b7la entre l&#8217;8 i el 15% en pacients amb NF1.<\/p>\n<p>&nbsp;<\/p>\n<p>Ara, els investigadors han sigut capa\u00e7os d&#8217;implantar fragments de nous MPNSTs de pacients en ratolins, i d\u2019a\u00efllar l\u00ednies cel\u00b7lulars dels mateixos tumors, proporcionant aix\u00ed un entorn de laboratori per estudiar aquests tumors. Un cop creades aquestes r\u00e8pliques biol\u00f2giques que mantenen les caracter\u00edstiques dels tumors originals, han realitzat una caracteritzaci\u00f3 exhaustiva del seu genoma, epigenoma i histologia. Aquesta aproximaci\u00f3 permet als investigadors entendre millor el comportament dels tumors i com podrien respondre als tractaments. Edgar Creus-Bachiller, estudiant de doctorat de l\u2019IDIBELL, i la Dra. Juana Fernandez, responsable de Mouse Lab de l\u2019IDIBELL, han liderat el treball experimental i posterior an\u00e0lisi.<\/p>\n<p>&nbsp;<\/p>\n<figure id=\"attachment_24658\" aria-describedby=\"caption-attachment-24658\" style=\"width: 300px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-24658 size-medium\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2023\/11\/HEREDITARY-CANCER_IGTP-300x200.jpg\" alt=\"\" width=\"300\" height=\"200\" srcset=\"https:\/\/idibell.cat\/wp-content\/uploads\/2023\/11\/HEREDITARY-CANCER_IGTP-300x200.jpg 300w, https:\/\/idibell.cat\/wp-content\/uploads\/2023\/11\/HEREDITARY-CANCER_IGTP-1024x683.jpg 1024w, https:\/\/idibell.cat\/wp-content\/uploads\/2023\/11\/HEREDITARY-CANCER_IGTP-768x512.jpg 768w, https:\/\/idibell.cat\/wp-content\/uploads\/2023\/11\/HEREDITARY-CANCER_IGTP-1536x1025.jpg 1536w, https:\/\/idibell.cat\/wp-content\/uploads\/2023\/11\/HEREDITARY-CANCER_IGTP-2048x1366.jpg 2048w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><figcaption id=\"caption-attachment-24658\" class=\"wp-caption-text\">Grup de c\u00e0ncer hereditari de l&#8217;IGTP, co-l\u00edder d&#8217;aquesta recerca<\/figcaption><\/figure>\n<p>De fet, els resultats han perm\u00e8s fins i tot una classificaci\u00f3 m\u00e9s precisa dels tumors, identificant que alguns pr\u00e8viament considerats MPNSTs podrien correspondre a altres entitats tumorals. Aquesta descoberta, combinada amb la possibilitat de realitzar proves amb f\u00e0rmacs per avaluar la seva efic\u00e0cia, obrir\u00e0 la porta a estrat\u00e8gies terap\u00e8utiques m\u00e9s personalitzades i beneficioses.<\/p>\n<p>&nbsp;<\/p>\n<p>Aquest treball ha estat realitzat en col\u00b7laboraci\u00f3 amb l&#8217;investigador Dr. Alberto Villanueva de l&#8217;IDIBELL i l&#8217;ICO. A m\u00e9s, Fern\u00e1ndez, forma part del nucli central del <a href=\"https:\/\/idibell.cat\/linstitut\/estructura-organitzativa\/comites-i-comissions\/\">Comit\u00e8 \u00c8tic d\u2019Experimentaci\u00f3 Animal<\/a>, l\u2019\u00f2rgan responsable de vetllar pel compliment de les 3Rs en tots els models d\u2019experimentaci\u00f3 animal. Aquest principi regeix l&#8217;experimentaci\u00f3 amb animals amb l&#8217;objectiu de reempla\u00e7ar l&#8217;\u00fas d&#8217;animals sempre que sigui possible, reduir al m\u00ednim el nombre d&#8217;animals utilitzats, i refinant els procediments per minimitzar el dolor als animals de laboratori.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><em>L\u2019Institut d&#8217;Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) \u00e9s un centre de recerca en biomedicina creat l\u2019any 2004. Est\u00e0 participat per l&#8217;Hospital Universitari de Bellvitge i l\u2019Hospital de Viladecans de l&#8217;Institut Catal\u00e0 de la Salut, l&#8217;Institut Catal\u00e0 d&#8217;Oncologia, la Universitat de Barcelona i l\u2019Ajuntament de l\u2019Hospitalet de Llobregat.<\/em><\/p>\n<p><em>L\u2019IDIBELL \u00e9s membre del Campus d&#8217;Excel\u00b7l\u00e8ncia Internacional de la Universitat de Barcelona HUBc i forma part de la instituci\u00f3 CERCA de la Generalitat de Catalunya. L&#8217;any 2009 es va convertir en un dels cinc primers centres d\u2019investigaci\u00f3 espanyols acreditats com a institut d\u2019investigaci\u00f3 sanit\u00e0ria per l\u2019Instituto de Salud Carlos III. A m\u00e9s, forma part del programa \u201cHR Excellence in Research\u201d de la Uni\u00f3 Europea i \u00e9s membre de EATRIS i REGIC. Des de l\u2019any 2018, l\u2019IDIBELL \u00e9s un Centro Acreditado de la Fundaci\u00f3n Cient\u00edfica AECC (FCAECC).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Aquesta millora obre la porta a estrat\u00e8gies terap\u00e8utiques m\u00e9s personalitzades i ha quedat recollida a un article publicat recentment a la revista Molecular Oncology.<\/p>\n","protected":false},"author":8,"featured_media":24657,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[332,417,446,447,452,346],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-15 23:29:11","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/24617"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=24617"}],"version-history":[{"count":3,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/24617\/revisions"}],"predecessor-version":[{"id":24660,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/24617\/revisions\/24660"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/24657"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=24617"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=24617"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=24617"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}