{"id":24387,"date":"2023-11-02T12:53:56","date_gmt":"2023-11-02T11:53:56","guid":{"rendered":"https:\/\/idibell.cat\/?p=24387"},"modified":"2023-11-02T12:53:56","modified_gmt":"2023-11-02T11:53:56","slug":"un-estudi-avanca-en-la-comprensio-dels-mecanismes-de-resistencia-d-haemophilus-parainfluenzae","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2023\/11\/un-estudi-avanca-en-la-comprensio-dels-mecanismes-de-resistencia-d-haemophilus-parainfluenzae\/","title":{"rendered":"Un estudi avan\u00e7a en la comprensi\u00f3 dels mecanismes de resist\u00e8ncia d\u2019 \u2018Haemophilus parainfluenzae\u2019"},"content":{"rendered":"

Un estudi desenvolupat al Servei de Microbiologia de l\u2019Hospital Universitari de Bellvitge i el Grup de Recerca d\u2019Infeccions Bacterianes<\/a> de l\u2019IDIBELL ha detectat per primera vegada l\u2019adquisici\u00f3 d\u2019una beta-lactamassa d\u2019espectre est\u00e8s (ESBL) CTX-M-15 en ceps multiresistents d\u2019Haemophilus parainfluenzae<\/em> a\u00efllats de mostres urogenitals. Aquesta troballa, publicada a International Journal of Antimicrobial Agents<\/em><\/a>, destaca la possibilitat que aquest mecanisme de resist\u00e8ncia es propagui a altres pat\u00f2gens de transmissi\u00f3 sexual.<\/p>\n

El patogen oportunista H. parainfluenzae<\/em> colonitza les vies respirat\u00f2ries i el tracte urogenital hum\u00e0. El material gen\u00e8tic d\u2019aquest bacteri t\u00e9 una alta plasticitat, cosa que li permet actuar com a possible reservori de gens de resist\u00e8ncia. L\u2019augment de la prevalen\u00e7a de ceps multiresistents detectats en els darrers anys, combinat amb l\u2019increment d’infeccions urogenitals associades a aquest microorganisme, subratlla la necessitat de comprendre detalladament els seus mecanismes d’adquisici\u00f3 i propagaci\u00f3 de resist\u00e8ncia antibi\u00f2tica.<\/p>\n

Aquest treball descriu els mecanismes moleculars de resist\u00e8ncia associats a quatre ceps multiresistents d\u2019H. parainfluenzae<\/em> a\u00efllats en pacients amb uretritis. Els ceps eren resistents a sis fam\u00edlies d’antibi\u00f2tics, incloent beta-lact\u00e0mics, fluoroquinolones, macr\u00f2lids, tetraciclina, cloranfenicol i cotrimoxazol. A m\u00e9s, tenien com a particularitat un perfil de resist\u00e8ncia compatible amb la pres\u00e8ncia de l\u2019enzim ESBL, cosa que no s\u2019havia descrit anteriorment en aquesta esp\u00e8cie. Mitjan\u00e7ant seq\u00fcenciaci\u00f3, es va identificar una beta-lactamassa blaCTX-M-15 integrada al genoma a causa de la transposici\u00f3 de nous elements gen\u00e8tics m\u00f2bils que conferien nivells elevats de resist\u00e8ncia a les cefalosporines.<\/p>\n

Aquesta ha estat la primera vegada que es detecta aquesta beta-lactamassa a H. parainfluenzae<\/em>. El potencial d\u2019aquest patogen per acumular determinants de resist\u00e8ncia antibi\u00f2tica, unit a la possibilitat de transmetre aquests elements a altres pat\u00f2gens associats a infeccions de transmissi\u00f3 sexual, \u00e9s un motiu de preocupaci\u00f3 per a la salut p\u00fablica.<\/p>\n","protected":false},"excerpt":{"rendered":"

Aquesta troballa, publicada a International Journal of Antimicrobial Agents, destaca la possibilitat que aquest mecanisme de resist\u00e8ncia es propagui a altres pat\u00f2gens de transmissi\u00f3 sexual.<\/p>\n","protected":false},"author":8,"featured_media":24388,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[480,334,479],"tags":[],"class_list":["post-24387","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-epidemiologia-de-les-infeccions-bacterianes-patogenesis-i-bases-moleculars-de-la-resistencia-al-antimicrobians","category-medicina-translacional","category-p-de-malalties-infeccioses-i-transplantaments"],"publishpress_future_action":{"enabled":false,"date":"2025-01-29 05:19:23","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/24387","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=24387"}],"version-history":[{"count":1,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/24387\/revisions"}],"predecessor-version":[{"id":24389,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/24387\/revisions\/24389"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/24388"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=24387"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=24387"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=24387"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}