{"id":24092,"date":"2023-08-31T09:05:19","date_gmt":"2023-08-31T07:05:19","guid":{"rendered":"https:\/\/idibell.cat\/?p=24092"},"modified":"2023-08-31T09:57:14","modified_gmt":"2023-08-31T07:57:14","slug":"nous-avencos-en-lanalisi-dels-mecanismes-que-expliquen-el-paper-dual-de-tgf-beta-en-carcinoma-hepatocellular","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2023\/08\/nous-avencos-en-lanalisi-dels-mecanismes-que-expliquen-el-paper-dual-de-tgf-beta-en-carcinoma-hepatocellular\/","title":{"rendered":"Nous aven\u00e7os en l&#8217;an\u00e0lisi dels mecanismes que expliquen el paper dual de TGF-beta en carcinoma hepatocel\u00b7lular"},"content":{"rendered":"<p>Una investigaci\u00f3 liderada pel grup de <a href=\"https:\/\/idibell.cat\/recerca\/area-de-cancer\/programa-de-mecanismes-molleculars-i-terapia-experimental-en-oncologia-oncobell\/tgf-beta-i-cancer\/\">TGF-Beta i C\u00e0ncer<\/a> de l&#8217;IDIBELL ha disseccionat el paper de la prote\u00efna NOX4 en la resposta al TGF-beta, un dels factors que controla l&#8217;aven\u00e7 del carcinoma hepatocel\u00b7lular, el tipus m\u00e9s com\u00fa de c\u00e0ncer de fetge.<\/p>\n<p>&nbsp;<\/p>\n<p>L&#8217;equip dirigit per la Dra. Isabel Fabregat, investigadora de l&#8217;IDIBELL i CIBEREHD, ha demostrat que NOX4 \u00e9s necessari per frenar el creixement de les c\u00e8l\u00b7lules canceroses en resposta a TGF-beta, com a part de les accions supressores de tumors d&#8217;aquest factor. No obstant aix\u00f2, en contra del que s&#8217;esperava, el pron\u00f2stic dels pacients que expressen alts nivells de NOX4 i TGF-beta \u00e9s menys favorable, cosa que suggereix que aquesta prote\u00efna en certs contextos tamb\u00e9 pot promoure accions pro-tumorog\u00e8niques. Davant d&#8217;aquest fet, els autors van aprofundir en el paper de NOX4 en resposta a TGF-beta demostrant que NOX4 tamb\u00e9 interv\u00e9 en la seva capacitat per induir migraci\u00f3 i invasi\u00f3, a trav\u00e9s de la regulaci\u00f3 del citoesquelet cel\u00b7lular.<\/p>\n<p>&nbsp;<\/p>\n<p>\u201cLes nostres troballes proporcionen una visi\u00f3 m\u00e9s profunda de com NOX4 i TGF-beta interactuen en el c\u00e0ncer de fetge. Aix\u00f2 podria obrir la porta a noves opcions de tractament i enfocaments personalitzats per als pacients&#8221;, afirma la Dra. Fabregat. I segueix: \u201cNOX4 ajuda a controlar el creixement del tumor, per\u00f2 tamb\u00e9 \u00e9s necessari perqu\u00e8 les c\u00e8l\u00b7lules canceroses es moguin i s\u2019estenguin\u201d.<\/p>\n<p>&nbsp;<\/p>\n<p>El treball s&#8217;ha realitzat en el context d&#8217;una col\u00b7laboraci\u00f3 dins del CIBEREHD, amb el grup de la Dra. M. Luz Mart\u00ednez-Chantar (CIC Biogune, Biscaia), i una col\u00b7laboraci\u00f3 internacional amb el grup del Dr. Gianluigi Giannelli (IRCCS Saverio De Bellis Research Hospital, Bari), i ha comptat amb el suport de l&#8217;Associaci\u00f3 Espanyola contra el C\u00e0ncer (AECC) i de l&#8217;Ag\u00e8ncia Estatal de Recerca (MICINN).<\/p>\n<p>&nbsp;<\/p>\n<p>El carcinoma hepatocel\u00b7lular \u00e9s una de les neopl\u00e0sies malignes m\u00e9s mortals a tot el m\u00f3n a causa de la seva alta taxa de recurr\u00e8ncia, alt potencial metast\u00e0tic i resist\u00e8ncia als medicaments. Per aquest motiu, els resultats d&#8217;aquesta investigaci\u00f3 s\u00f3n molt valuosos per a una comprensi\u00f3 millor i eventualment una lluita m\u00e9s efectiva contra aquesta malaltia.<\/p>\n<p>&nbsp;<\/p>\n<p><em>L\u2019Institut d&#8217;Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) \u00e9s un centre de recerca en biomedicina creat l\u2019any 2004. Est\u00e0 participat per l&#8217;Hospital Universitari de Bellvitge i l\u2019Hospital de Viladecans de l&#8217;Institut Catal\u00e0 de la Salut, l&#8217;Institut Catal\u00e0 d&#8217;Oncologia, la Universitat de Barcelona i l\u2019Ajuntament de l\u2019Hospitalet de Llobregat.<\/em><\/p>\n<p><em>L\u2019IDIBELL \u00e9s membre del Campus d&#8217;Excel\u00b7l\u00e8ncia Internacional de la Universitat de Barcelona HUBc i forma part de la instituci\u00f3 CERCA de la Generalitat de Catalunya. L&#8217;any 2009 es va convertir en un dels cinc primers centres d\u2019investigaci\u00f3 espanyols acreditats com a institut d\u2019investigaci\u00f3 sanit\u00e0ria per l\u2019Instituto de Salud Carlos III. A m\u00e9s, forma part del programa \u201cHR Excellence in Research\u201d de la Uni\u00f3 Europea i \u00e9s membre de EATRIS i REGIC. Des de l\u2019any 2018, l\u2019IDIBELL \u00e9s un Centro Acreditado de la Fundaci\u00f3n Cient\u00edfica AECC (FCAECC).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Els resultats posen de manifest que una prote\u00efna, la NADPH oxidasa NOX4, que havia estat descrita com a mediadora de la mort cel\u00b7lular indu\u00efda per TGF-beta, tamb\u00e9 participa en la resposta pro-tumorog\u00e8nica a aquest factor, concretament mitjan\u00e7ant la seva capacitat pro-migrat\u00f2ria e invasiva.<\/p>\n","protected":false},"author":8,"featured_media":24093,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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