El proc\u00e9s pel qual es formen els \u00f2rgans, passant d’un estat immadur a un completament madur i funcional, \u00e9s extremadament complex i desconegut, encara hi ha molts mecanismes cel\u00b7lulars i moleculars que controlen el proc\u00e9s que s\u00f3n desconeguts. En el cas de l’intest\u00ed, aix\u00f2 implica adquirir la capacitat de digerir i absorbir els nutrients, proc\u00e9s controlat molecularment per factors de transcripci\u00f3 espec\u00edfics. Aquests factors de transcripci\u00f3 s\u00f3n els responsables d’activar i desactivar els gens que codifiquen prote\u00efnes que permeten a les c\u00e8l\u00b7lules transitar entre c\u00e8l\u00b7lules mare fetals o adultes i c\u00e8l\u00b7lules diferenciades.<\/p>\n
Desentrellar el funcionament de determinats factors de transcripci\u00f3<\/strong> en la formaci\u00f3 de l’intest\u00ed ha estat l’objectiu de l’equip del Professor Kim Bak Jensen<\/strong>, de la Novo Nordisk Foundation of Stem Cell Medicine (reNEW), en el que tamb\u00e9 hi ha participat el Dr. Jordi Guiu<\/strong>, cap del grup de recerca en Plasticitat i Regeneraci\u00f3 Cel\u00b7lular<\/a> de l’Institut d’Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) i del Programa de Translaci\u00f3 Cl\u00ednica de Medicina Regenerativa de Catalunya (P-CMR[C]). Ara els seus resultats es presenten en dos articles publicats a la revista cient\u00edfica Science Advances<\/em><\/a>.<\/p>\n En els dos estudis publicats, l’equip cient\u00edfic utilitza com a model l\u2019organoid d’intest\u00ed<\/strong>, una estructura tridimensional similars a miniintestins creada al laboratori a partir de c\u00e8l\u00b7lules mare. Gr\u00e0cies a la utilitzaci\u00f3 de diferents aproximacions moleculars demostren la utilitat dels models d’organoids per identificar els factors que regulen el dest\u00ed cel\u00b7lular, i revela que els factors de transcripci\u00f3 SMARCA4 i SMARCC1 eviten la diferenciaci\u00f3 preco\u00e7 de les c\u00e8l\u00b7lules mare durant el desenvolupament intestinal. A m\u00e9s, identifiquen l’activitat transcripcional de la prote\u00efna YAP com a principal reguladora de l’estat fetal immadur.<\/p>\n El Dr. Jordi Guiu<\/strong> explica: “Entendre la transici\u00f3 d’un \u00f2rgan immadur a un \u00f2rgan madur ens podria ajudar a con\u00e8ixer com podem entrenar c\u00e8l\u00b7lules cultivades al laboratori per transitar en diferents estadis de maduresa. Aquest coneixement en \u00faltima inst\u00e0ncia ajudaria a generar ter\u00e0pies cel\u00b7lulars, per exemple, mitjan\u00e7ant la producci\u00f3 de c\u00e8l\u00b7lules epitelials al laboratori que es podrien trasplantar a pacients amb ulceres intestinals com poden ser el pacients amb la malaltia de Chron, o pacients tractats amb radioter\u00e0pia a la cavitat abdominal, entre d\u2019altres defectes epitelials<\/em>“.<\/p>\n Cr\u00e8dit imatge: Novo Nordisk Foundation Center for Stem Cell Medicine<\/p>\n <\/p>\n <\/p>\n L\u2019Institut d’Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) \u00e9s un centre de recerca en biomedicina creat l\u2019any 2004. Est\u00e0 participat per l’Hospital Universitari de Bellvitge i l\u2019Hospital de Viladecans de l’Institut Catal\u00e0 de la Salut, l’Institut Catal\u00e0 d’Oncologia, la Universitat de Barcelona i l\u2019Ajuntament de l\u2019Hospitalet de Llobregat.<\/em><\/p>\n L\u2019IDIBELL \u00e9s membre del Campus d’Excel\u00b7l\u00e8ncia Internacional de la Universitat de Barcelona HUBc i forma part de la instituci\u00f3 CERCA de la Generalitat de Catalunya. L’any 2009 es va convertir en un dels cinc primers centres d\u2019investigaci\u00f3 espanyols acreditats com a institut d\u2019investigaci\u00f3 sanit\u00e0ria per l\u2019Instituto de Salud Carlos III. A m\u00e9s, forma part del programa \u201cHR Excellence in Research\u201d de la Uni\u00f3 Europea i \u00e9s membre de EATRIS i REGIC. Des de l\u2019any 2018, l\u2019IDIBELL \u00e9s un Centro Acreditado de la Fundaci\u00f3n Cient\u00edfica AECC (FCAECC).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":" En els dos estudis publicats, l’equip cient\u00edfic utilitza com a model l\u2019organoid d’intest\u00ed, una estructura tridimensional similars a miniintestins creada al laboratori a partir de c\u00e8l\u00b7lules mare. Desentrellar el funcionament de determinats factors de transcripci\u00f3 en la formaci\u00f3 de l’intest\u00ed ha estat l’objectiu de l’equip.<\/p>\n","protected":false},"author":8,"featured_media":24013,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[349,482,494],"tags":[],"class_list":["post-24012","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicina-regenerativa","category-p-de-medicina-regenerativa","category-plasticitat-cellular"],"publishpress_future_action":{"enabled":false,"date":"2025-01-25 06:57:04","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/24012","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=24012"}],"version-history":[{"count":3,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/24012\/revisions"}],"predecessor-version":[{"id":24018,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/24012\/revisions\/24018"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/24013"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=24012"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=24012"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=24012"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}