{"id":23994,"date":"2023-07-12T09:11:04","date_gmt":"2023-07-12T07:11:04","guid":{"rendered":"https:\/\/idibell.cat\/?p=23994"},"modified":"2023-07-12T09:11:04","modified_gmt":"2023-07-12T07:11:04","slug":"la-monoterapia-podria-reemplacar-la-terapia-combinada-en-la-endocarditis","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2023\/07\/la-monoterapia-podria-reemplacar-la-terapia-combinada-en-la-endocarditis\/","title":{"rendered":"La monoterapia podria reempla\u00e7ar la ter\u00e0pia combinada en la endocarditis"},"content":{"rendered":"<p>L\u2019estudi multic\u00e8ntric sobre el tractament antibi\u00f2tic de l\u2019endocarditis estreptoc\u00f2ccica, publicat a la revista <em>Clinical Infectious Diseases, <\/em>ha comptat amb les dades de 914 pacients i la participaci\u00f3 de 40 centres hospitalaris de l\u2019Estat que formen part de la cohort prospectiva GAMES (<a href=\"https:\/\/www.seicav.org\/grupos\/\">Grupo de Apoyo al Manejo de la Endocarditis en Espa\u00f1a<\/a>), de la Societat Espanyola d\u2019Infeccions Cardiovasculars (SEICAV). La investigaci\u00f3 ha estat liderada per professionals del Servei de Malalties Infeccioses de l\u2019Hospital Universitari de Bellvitge i l\u2019Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL).<\/p>\n<p>L\u2019endocarditis infecciosa \u00e9s una malaltia heterog\u00e8nia i greu, amb una taxa de cirurgia major de m\u00e9s del 50% i una mortalitat del 25%. Fins ara, les guies internacionals recomanen l\u2019\u00fas de ter\u00e0pia combinada amb betalact\u00e0mics m\u00e9s aminoglic\u00f2sids en les endocarditis causades per estreptococs amb sensibilitat interm\u00e8dia a penicil\u00b7lina, per\u00f2 els aminoglic\u00f2sids s\u2019associen a desenvolupament d\u2019insufici\u00e8ncia renal i altres efectes adversos importants.<\/p>\n<p>Segons els resultats de l\u2019estudi liderat per l\u2019HUB i l\u2019IDIBELL, la monoter\u00e0pia amb una cefalosporina de tercera generaci\u00f3 \u00e9s una alternativa efica\u00e7 i segura al tractament combinat amb aminoglic\u00f2sids, presentant similars taxes de mortalitat intrahospital\u00e0ria i recaigudes. Els resultats de l\u2019estudi haurien de ser implementats a les properes guies internacionals pel maneig de l\u2019endocarditis infecciosa i canviar la pr\u00e0ctica cl\u00ednica.<\/p>\n<p>Com a centre hospitalari d\u2019alta complexitat, l\u2019Hospital Universitari de Bellvitge at\u00e9n anualment unes 80 endocarditis, dona suport al maneig de centres comarcals, i coordina la Unitat d\u2019Endocarditis de la regi\u00f3 sanit\u00e0ria Metropolitana Sud. Identificar noves estrat\u00e8gies que permetin millorar el diagn\u00f2stic i el tractament d\u2019aquesta patologia infecciosa greu \u00e9s un tema prioritari de recerca.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><em>L\u2019Institut d&#8217;Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) \u00e9s un centre de recerca en biomedicina creat l\u2019any 2004. Est\u00e0 participat per l&#8217;Hospital Universitari de Bellvitge i l\u2019Hospital de Viladecans de l&#8217;Institut Catal\u00e0 de la Salut, l&#8217;Institut Catal\u00e0 d&#8217;Oncologia, la Universitat de Barcelona i l\u2019Ajuntament de l\u2019Hospitalet de Llobregat.<\/em><\/p>\n<p><em>L\u2019IDIBELL \u00e9s membre del Campus d&#8217;Excel\u00b7l\u00e8ncia Internacional de la Universitat de Barcelona HUBc i forma part de la instituci\u00f3 CERCA de la Generalitat de Catalunya. L&#8217;any 2009 es va convertir en un dels cinc primers centres d\u2019investigaci\u00f3 espanyols acreditats com a institut d\u2019investigaci\u00f3 sanit\u00e0ria per l\u2019Instituto de Salud Carlos III. A m\u00e9s, forma part del programa \u201cHR Excellence in Research\u201d de la Uni\u00f3 Europea i \u00e9s membre de EATRIS i REGIC. Des de l\u2019any 2018, l\u2019IDIBELL \u00e9s un Centro Acreditado de la Fundaci\u00f3n Cient\u00edfica AECC (FCAECC).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Investigadors del grup d\u2019Infeccions respirat\u00f2ries i en l&#8217;hoste immunocomprom\u00e8s de l\u2019IDIBELL i de l\u2019Hospital Universitari de Bellvitge han demostrat que la monoter\u00e0pia amb una cefalosporina de 3a generaci\u00f3 \u00e9s efica\u00e7 i segura com a tractament d\u2019aquesta malaltia infecciosa greu. Aquests resultats canviaran les recomanacions internacionals per al seu maneig.<\/p>\n","protected":false},"author":8,"featured_media":23995,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[391,334,479],"tags":[],"class_list":["post-23994","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-infeccions-respiratories-i-en-lhoste-immunocompromes","category-medicina-translacional","category-p-de-malalties-infeccioses-i-transplantaments"],"publishpress_future_action":{"enabled":false,"date":"2024-11-28 22:48:51","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/23994","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=23994"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/23994\/revisions"}],"predecessor-version":[{"id":23997,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/23994\/revisions\/23997"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/23995"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=23994"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=23994"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=23994"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}