{"id":23835,"date":"2023-06-01T09:20:22","date_gmt":"2023-06-01T07:20:22","guid":{"rendered":"https:\/\/idibell.cat\/?p=23835"},"modified":"2023-06-01T09:20:22","modified_gmt":"2023-06-01T07:20:22","slug":"la-despolimeritzacio-dels-microtubuls-contribueix-a-lalliberacio-espontania-de-neurotransmissors","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2023\/06\/la-despolimeritzacio-dels-microtubuls-contribueix-a-lalliberacio-espontania-de-neurotransmissors\/","title":{"rendered":"La despolimeritzaci\u00f3 dels microt\u00fabuls contribueix a l\u2018alliberaci\u00f3 espont\u00e0nia de neurotransmissors"},"content":{"rendered":"<p>El grup de recerca en Neurobiologia Cel\u00b7lular i Molecular de l&#8217;Institut d&#8217;Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) i de l&#8217;Institut de Neuroci\u00e8ncies de la Universitat de Barcelona (UB) liderat pel <strong>Dr. Artur Llobet<\/strong> ha publicat un estudi que revela que els microt\u00fabuls, a m\u00e9s de la seva funci\u00f3 estructural coneguda dins les c\u00e8l\u00b7lules, tamb\u00e9 exerceixen una influ\u00e8ncia activa en la comunicaci\u00f3 neuronal.<\/p>\n<p>L&#8217;estudi, publicat a la revista <a href=\"https:\/\/www.nature.com\/articles\/s42003-023-04779-1\"><em>Communications Biology<\/em><\/a> mostra un augment significatiu en la freq\u00fc\u00e8ncia de l&#8217;alliberaci\u00f3 espont\u00e0nia de neurotransmissors quan els microt\u00fabuls es despolimeritzen. La conseq\u00fc\u00e8ncia \u00e9s una major comunicaci\u00f3 neuronal sense necessitat de rebre est\u00edmuls externs espec\u00edfics.<\/p>\n<p>Tal com explica la <strong>Dra. Cec\u00edlia Velasco<\/strong>, primera autora del treball i membre de la Facultat de Medicina i Ci\u00e8ncies de la Salut de la UB, a qualsevol sinapsi qu\u00edmica, els terminals presin\u00e0ptics alliberen els neurotransmissors en resposta a un senyal el\u00e8ctric, definint aix\u00ed les bases de la comunicaci\u00f3 neuronal. Ara b\u00e9, una petita part dels neurotransmissors s&#8217;alliberen espont\u00e0niament, sense necessitat de l&#8217;arribada d&#8217;un est\u00edmul. Com i per qu\u00e8 aix\u00f2 passa encara \u00e9s una inc\u00f2gnita que aquest treball mira de desentrellar.<\/p>\n<p>L&#8217;estudi s&#8217;ha centrat en el paper dels microt\u00fabuls, que s\u00f3n un element del citoesquelet cel\u00b7lular que cont\u00ednuament estan creixent i decreixent. Aquesta propietat determina m\u00faltiples funcions cel\u00b7lulars com poden ser la divisi\u00f3 o el moviment cel\u00b7lular. Per primera vegada, s&#8217;ha observat com la din\u00e0mica dels microt\u00fabuls tamb\u00e9 \u00e9s rellevant per l&#8217;alliberament espontani de neurotransmissors. Els resultats de l&#8217;estudi suggereixen que les vies moleculars que promouen l&#8217;escur\u00e7ament dels microt\u00fabuls podrien ser utilitzades per les neurones per establir la comunicaci\u00f3 neuronal en abs\u00e8ncia de senyals el\u00e8ctrics.<\/p>\n<p>Aquest descobriment obre la possibilitat a explicar els mecanismes que promouen els alts nivells d&#8217;alliberament espontani de neurotransmissors que es donen durant les etapes primerenques del desenvolupament. La identificaci\u00f3 d&#8217;un mecanisme que pot ser clau en l&#8217;assemblatge dels circuits neuronals porta a considerar l&#8217;estabilitat de microt\u00fabuls no solament com un determinant clau de la connectivitat sin\u00e0ptica, sin\u00f3 tamb\u00e9 com una nova diana farmacol\u00f2gica capa\u00e7 de regular l&#8217;alliberament de neurotransmissors.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><em>L\u2019Institut d&#8217;Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) \u00e9s un centre de recerca en biomedicina creat l\u2019any 2004. Est\u00e0 participat per l&#8217;Hospital Universitari de Bellvitge i l\u2019Hospital de Viladecans de l&#8217;Institut Catal\u00e0 de la Salut, l&#8217;Institut Catal\u00e0 d&#8217;Oncologia, la Universitat de Barcelona i l\u2019Ajuntament de l\u2019Hospitalet de Llobregat.<\/em><\/p>\n<p><em>L\u2019IDIBELL \u00e9s membre del Campus d&#8217;Excel\u00b7l\u00e8ncia Internacional de la Universitat de Barcelona HUBc i forma part de la instituci\u00f3 CERCA de la Generalitat de Catalunya. L&#8217;any 2009 es va convertir en un dels cinc primers centres d\u2019investigaci\u00f3 espanyols acreditats com a institut d\u2019investigaci\u00f3 sanit\u00e0ria per l\u2019Instituto de Salud Carlos III. A m\u00e9s, forma part del programa \u201cHR Excellence in Research\u201d de la Uni\u00f3 Europea i \u00e9s membre de EATRIS i REGIC. Des de l\u2019any 2018, l\u2019IDIBELL \u00e9s un Centro Acreditado de la Fundaci\u00f3n Cient\u00edfica AECC (FCAECC).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un estudi que revela que els microt\u00fabuls, a m\u00e9s de la seva funci\u00f3 estructural coneguda dins les c\u00e8l\u00b7lules, tamb\u00e9 exerceixen una influ\u00e8ncia activa en la comunicaci\u00f3 neuronal.<\/p>\n","protected":false},"author":8,"featured_media":23836,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[458,340,457],"tags":[],"class_list":["post-23835","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-neurobiologia-cellular-i-molecular","category-neurociencies","category-p-de-neurociencies"],"publishpress_future_action":{"enabled":false,"date":"2025-03-01 23:44:07","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/23835","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=23835"}],"version-history":[{"count":1,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/23835\/revisions"}],"predecessor-version":[{"id":23837,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/23835\/revisions\/23837"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/23836"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=23835"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=23835"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=23835"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}