{"id":23734,"date":"2023-05-11T10:48:57","date_gmt":"2023-05-11T08:48:57","guid":{"rendered":"https:\/\/idibell.cat\/?p=23734"},"modified":"2023-05-11T11:20:40","modified_gmt":"2023-05-11T09:20:40","slug":"les-terapies-personalitzades-basades-en-lestudi-de-les-alteracions-genetiques-podrien-incrementar-la-supervivencia-del-limfoma-nk-t-nasal","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2023\/05\/les-terapies-personalitzades-basades-en-lestudi-de-les-alteracions-genetiques-podrien-incrementar-la-supervivencia-del-limfoma-nk-t-nasal\/","title":{"rendered":"Les ter\u00e0pies personalitzades basades en l’estudi de les alteracions gen\u00e8tiques podrien incrementar la superviv\u00e8ncia del limfoma NK-T nasal"},"content":{"rendered":"

El limfoma NK-T nasal \u00e9s un tipus de limfoma molt agressiu que afecta normalment l’\u00e0rea nasal i orofar\u00edngia. Aquest limfoma, que tot i el tractament encara t\u00e9 mal pron\u00f2stic, a Europa es considera una malaltia rara per la seva baixa incid\u00e8ncia, per\u00f2, en canvi, \u00e9s molt m\u00e9s freq\u00fcent i prevalent en la poblaci\u00f3 de l’\u00c0sia Oriental i a l’Am\u00e8rica Llatina que representa entre un 5% i un 15% de tots els diagnosticats de limfoma.<\/p>\n

\u00c9s per aquest motiu que un grup de cient\u00edfics encap\u00e7alats per la investigadora de l’Institut d’Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) i hemat\u00f2loga de l’Institut Catal\u00e0 d’Oncologia (ICO), Eva Gonz\u00e1lez-Barca, amb la col\u00b7laboraci\u00f3 del Grup Espanyol de Limfomes i Tractaments de Medul\u00b7la \u00d2ssia (GETALMO), han realitzat un estudi comparatiu de l’immunofenotip, l’expressi\u00f3 g\u00e8nica i les mutacions entre Europa i l’\u00c0sia Oriental, amb la intenci\u00f3 de poder identificar noves dianes terap\u00e8utiques.<\/p>\n

El treball, publicat a la revista American Journal of Hematology<\/em><\/a>, ha reclutat 89 pacients (7 dels quals provinents de l’ICO l’Hospitalet i 1 de l’ICO Tarragona) i \u00e9s el m\u00e9s nombr\u00f3s fet al continent europeu.<\/p>\n

A partir d’aqu\u00ed, i un cop analitzats els resultats, s’ha observat que la malaltia es comporta de manera similar a la que afecta els asi\u00e0tics o als habitants de l’Am\u00e8rica Llatina on t\u00e9 m\u00e9s incid\u00e8ncia. A m\u00e9s, s’han identificat noves dianes per tal de poder confeccionar alternatives terap\u00e8utiques, ja que, encara, aquests malalts tenen un pron\u00f2stic dolent.<\/p>\n

“Aquest estudi ens ha donat l’oportunitat de poder fer una comparativa amb les dades que existien en els pa\u00efsos asi\u00e0tics i veure que es tracta de la mateixa malaltia tot i que all\u00e0, per una ra\u00f3 que encara desconeixem, t\u00e9 molta m\u00e9s prevalen\u00e7a<\/em>” assegura Gonz\u00e1lez-Barca<\/strong> i afegeix “el m\u00e9s important \u00e9s que hem trobat diverses alteracions gen\u00e8tiques que podrien ser utilitzades per dissenyar nous f\u00e0rmacs i millorar la superviv\u00e8ncia del limfoma NK-T nasal<\/em>“.<\/p>\n

Es tracta d’un tipus de limfoma molt agressiu al que, en els \u00faltims anys, s’ha incorporat un nou tractament anomenat L- asparginasa. Aquest nou f\u00e0rmac ha millorat la superviv\u00e8ncia en els pacients asi\u00e0tics, per\u00f2, en els estudis realitzats a occident, encara no hi ha dades que confirmin la millora en la superviv\u00e8ncia.<\/p>\n","protected":false},"excerpt":{"rendered":"

Un estudi centrat en aquesta malaltia fa la comparativa entre pacients de l\u2019Estat, on \u00e9s una malaltia minorit\u00e0ria, i els resultats de d\u2019altres estudis realitzats a l\u2019\u00c0sia Oriental i Am\u00e8rica Llatina on la malaltia t\u00e9 major freq\u00fc\u00e8ncia i prevalen\u00e7a entre la poblaci\u00f3.<\/p>\n","protected":false},"author":8,"featured_media":23735,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[332,447,449],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-04 21:24:44","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/23734"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=23734"}],"version-history":[{"count":1,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/23734\/revisions"}],"predecessor-version":[{"id":23736,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/23734\/revisions\/23736"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/23735"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=23734"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=23734"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=23734"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}