{"id":22744,"date":"2023-01-24T09:20:32","date_gmt":"2023-01-24T08:20:32","guid":{"rendered":"https:\/\/idibell.cat\/?p=22744"},"modified":"2024-02-16T15:18:03","modified_gmt":"2024-02-16T14:18:03","slug":"un-farmac-que-impulsa-la-regeneracio-de-les-cellules-mare-allarga-lesperanca-de-vida-en-ratolins","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2023\/01\/un-farmac-que-impulsa-la-regeneracio-de-les-cellules-mare-allarga-lesperanca-de-vida-en-ratolins\/","title":{"rendered":"Un f\u00e0rmac que impulsa la regeneraci\u00f3 de les c\u00e8l\u00b7lules mare allarga l\u2019esperan\u00e7a de vida en ratolins"},"content":{"rendered":"<p>Un equip d\u2019investigadors demostra que el trasplantament de c\u00e8l\u00b7lules mare de la sang pr\u00e8viament tractades amb un f\u00e0rmac que potencia la seva capacitat de regeneraci\u00f3 aconsegueix allargar l\u2019esperan\u00e7a de vida en ratolins. Els cient\u00edfics de l&#8217;Institut de Recerca Biom\u00e8dica de Bellvitge (IDIBELL) i del Programa de Translaci\u00f3 Cl\u00ednica en Medicina Regenerativa de Catalunya (P-CMR[C]), en col\u00b7laboraci\u00f3 amb la Universitat d&#8217;Ulm a Alemanya, han publicat els resultats a la revista <a href=\"https:\/\/www.nature.com\/articles\/s41536-022-00275-y\"><em>Regenerative Medicine<\/em><\/a> del grup <em>Nature<\/em>.<\/p>\n<p><iframe loading=\"lazy\" width=\"560\" height=\"315\" src=\"https:\/\/www.youtube.com\/embed\/MH4UUq-D2Qo?si=ZkV1f2nY6_ZRkjAz\" title=\"YouTube video player\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" allowfullscreen><\/iframe><\/p>\n<p>L&#8217;envelliment s&#8217;associa a la disminuci\u00f3 de la regeneraci\u00f3 dels teixits causada per l&#8217;esgotament de les c\u00e8l\u00b7lules mare. &#8220;<em>Aquest treball proporciona la primera prova de concepte en que es demostra que augmentar el potencial regeneratiu de les c\u00e8l\u00b7lules mare end\u00f2genes envellides podria representar una estrat\u00e8gia important per rejovenir els teixits i millorar la salut i l&#8217;esperan\u00e7a de vida en la gent gran<\/em>&#8220;, assegura la <strong>Dra. Carolina Florian<\/strong>, cap de grup a l&#8217;IDIBELL i el P-CMR[C] i l\u00edder del projecte.<\/p>\n<p>Les c\u00e8l\u00b7lules mare sangu\u00ednies, que donaran lloc a tots els tipus cel\u00b7lulars de la sang, contenen una gran quantitat de factors de regeneraci\u00f3. Aquests resultats mostren com el rejoveniment d&#8217;aquestes c\u00e8l\u00b7lules podria representar una <strong>estrat\u00e8gia efectiva per millorar l&#8217;envelliment de tot l&#8217;organisme<\/strong>, ja que sembla que la seva estimulaci\u00f3 podria ser suficient per rejovenir-ho tot.<\/p>\n<p>&nbsp;<\/p>\n<h3>Un f\u00e0rmac per rejovenir les c\u00e8l\u00b7lules mare sangu\u00ednies<\/h3>\n<p>El f\u00e0rmac utilitzat en aquest estudi per rejovenir les c\u00e8l\u00b7lules mare s&#8217;anomena CASIN, un inhibidor d&#8217;una prote\u00efna Cdc42. Els resultats mostren que el tractament de c\u00e8l\u00b7lules mare amb aquest inhibidor n&#8217;estimula la regeneraci\u00f3 i, en conseq\u00fc\u00e8ncia, el trasplantament millora l&#8217;esperan\u00e7a de vida en ratolins.<\/p>\n<p>La prote\u00efna Cdc42 est\u00e0 involucrada a la polaritat cel\u00b7lular, i \u00e9s l&#8217;encarregada de mantenir la simetria durant la divisi\u00f3 cel\u00b7lular. La seva activitat incrementa amb l&#8217;edat i la inhibici\u00f3, amb un gran potencial rejovenidor, es pot aconseguir amb un tractament breu amb CASIN en ratolins d&#8217;edat avan\u00e7ada.<\/p>\n<p>Aquest treball ha estat possible gr\u00e0cies a la col\u00b7laboraci\u00f3 de l&#8217;IDIBELL i el P-CMR[C] amb l&#8217;equip del professor Hartmut Geiger de la Universitat d&#8217;Ulm (Alemanya) i el professor Yi Zheng de l&#8217;Hospital de nens de Cincinnati.<\/p>\n<p><em>\u00a0<\/em><\/p>\n<p><em>L\u2019Institut d&#8217;Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) \u00e9s un centre de recerca en biomedicina creat l\u2019any 2004. Est\u00e0 participat per l&#8217;Hospital Universitari de Bellvitge i l\u2019Hospital de Viladecans de l&#8217;Institut Catal\u00e0 de la Salut, l&#8217;Institut Catal\u00e0 d&#8217;Oncologia, la Universitat de Barcelona i l\u2019Ajuntament de l\u2019Hospitalet de Llobregat.<\/em><\/p>\n<p><em>L\u2019IDIBELL \u00e9s membre del Campus d&#8217;Excel\u00b7l\u00e8ncia Internacional de la Universitat de Barcelona HUBc i forma part de la instituci\u00f3 CERCA de la Generalitat de Catalunya. L&#8217;any 2009 es va convertir en un dels cinc primers centres d\u2019investigaci\u00f3 espanyols acreditats com a institut d\u2019investigaci\u00f3 sanit\u00e0ria per l\u2019Instituto de Salud Carlos III. A m\u00e9s, forma part del programa \u201cHR Excellence in Research\u201d de la Uni\u00f3 Europea i \u00e9s membre de EATRIS i REGIC. Des de l\u2019any 2018, l\u2019IDIBELL \u00e9s un Centro Acreditado de la Fundaci\u00f3n Cient\u00edfica AECC (FCAECC).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>El treball posa el focus en el rejoveniment de les c\u00e8l\u00b7lules mare de la sang end\u00f2genes com a possible estrat\u00e8gia per regenerar els teixits, millorar la salut i l&#8217;esperan\u00e7a de vida de les persones grans.<\/p>\n","protected":false},"author":8,"featured_media":22745,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1,484,349,482],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-09 19:35:07","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/22744"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=22744"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/22744\/revisions"}],"predecessor-version":[{"id":25077,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/22744\/revisions\/25077"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/22745"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=22744"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=22744"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=22744"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}