{"id":22570,"date":"2022-12-07T11:39:08","date_gmt":"2022-12-07T10:39:08","guid":{"rendered":"https:\/\/idibell.cat\/?p=22570"},"modified":"2022-12-07T11:54:00","modified_gmt":"2022-12-07T10:54:00","slug":"demostren-lefectivitat-dun-nou-test-per-mesurar-lapatia-en-la-malaltia-de-huntington","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2022\/12\/demostren-lefectivitat-dun-nou-test-per-mesurar-lapatia-en-la-malaltia-de-huntington\/","title":{"rendered":"Demostren l\u2019efectivitat d\u2019un nou test per mesurar l\u2019apatia en la malaltia de Huntington"},"content":{"rendered":"

La investigaci\u00f3, liderada por la Dra. Estela C\u00e0mara i la investigadora de doctorat Audrey De Paepe, ajuda a entendre l\u2019apatia, el perfil m\u00e9s psiqui\u00e0tric de la malaltia de Huntington, que t\u00e9 un impacte molt gran en la qualitat de vida dels pacients.\u00a0<\/span>\u00a0<\/span><\/p>\n

L’apatia, que es defineix com una falta de motivaci\u00f3 i inter\u00e8s generalitzada, \u00e9s un s\u00edndrome m\u00e9s complex que es divideix en tres subtipus: l’apatia cognitiva (falta d\u2019iniciativa per a la realitzaci\u00f3 d\u2019activitats cognitives), el d\u00e8ficit en l’autoactivaci\u00f3 (falta d\u2019empenta per comen\u00e7ar les coses) i l’apatia emocional (disminuci\u00f3 d\u2019expressi\u00f3 d\u2019emocions). Con\u00e8ixer b\u00e9 l’apatia \u00e9s clau, ja que \u00e9s una manifestaci\u00f3 patol\u00f2gica en m\u00faltiples desordres neurol\u00f2gics. Per exemple, en el cas de la malaltia de Huntington, l’apatia es considera un marcador de progressi\u00f3.<\/span>\u00a0<\/span><\/p>\n

Ara un grup de l’IDIBELL i la Universitat de Barcelona ha demostrat l’efectivitat d’un test per mesurar l’apatia en la malaltia de Huntington que a m\u00e9s \u00e9s capa\u00e7 de discernir diferents perfils ap\u00e0tics. Aquest test, anomenat LARS-s (sigles en angl\u00e8s de <\/span>Short-Lille Apathy Rating Scale<\/span><\/i>) consisteix en una entrevista estandarditzada basada en una escala dicot\u00f2mica estructurada, reduint aix\u00ed les interpretacions subjectives. “<\/span>Hi ha molta variabilitat entre els diferents tipus ap\u00e0tics, per tant, estudiar els perfils d’apatia de cada pacient pot obrir noves perspectives per entendre aquesta simptomatologia que actualment t\u00e9 un tractament molt redu\u00eft.\u201d A m\u00e9s a m\u00e9s, \u201c\u00e9s clau tenir escales cl\u00edniques que ens permetin establir un diagn\u00f2stic diferencial apropiat amb altres s\u00edmptomes com la depressi\u00f3 o el deteriorament cognitiu<\/span><\/i> ” afegeix la <\/span>Dra. Estela C\u00e0mara<\/span><\/b>, l\u00edder del projecte i investigadora principal de l’IDIBELL.<\/span>\u00a0<\/span><\/p>\n

En paral\u00b7lel a la validaci\u00f3 del test, l’estudi intenta correlacionar els diferents perfils d’apatia amb l’activaci\u00f3 de determinades regions cerebrals a partir de la neuroimatge. Els resultats mostren que anat\u00f2micament l’apatia est\u00e0 relacionada amb xarxes motores, cognitives i l\u00edmbiques, i que existeix certa correspond\u00e8ncia entre els diferents perfils i l’activaci\u00f3 de determinats ganglis corticals i subcorticals. La <\/span>Dra. Estela C\u00e0mara<\/span><\/b> conclou que “<\/span>aquests descobriments incentiven profunditzar en l’estudi dels subtipus d’apatia per identificar dianes terap\u00e8utiques personalitzades en trastorns neurol\u00f2gics a m\u00e9s de la malaltia de Huntington <\/span><\/i>“.<\/span>\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

El test \u00e9s capa\u00e7 de distingir diferents subtipus d\u2019apatia en els pacients de Huntington, el que obre noves perspectives a entendre aquesta simptomatologia considerada un marcador de progressi\u00f3.\u00a0<\/p>\n","protected":false},"author":8,"featured_media":22572,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1,368,340,457],"tags":[],"class_list":["post-22570","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sin-categorizar","category-cognicio-i-plasticitat-cerebral","category-neurociencies","category-p-de-neurociencies"],"publishpress_future_action":{"enabled":false,"date":"2024-12-01 02:47:31","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/22570","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=22570"}],"version-history":[{"count":3,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/22570\/revisions"}],"predecessor-version":[{"id":22573,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/22570\/revisions\/22573"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/22572"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=22570"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=22570"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=22570"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}