{"id":22046,"date":"2022-08-17T10:08:29","date_gmt":"2022-08-17T08:08:29","guid":{"rendered":"https:\/\/idibell.cat\/?p=22046"},"modified":"2022-08-17T10:08:29","modified_gmt":"2022-08-17T08:08:29","slug":"una-troballa-incidental-en-biopsies-de-prostata-permet-diagnosticar-una-malaltia-sistemica-no-sospitada-previament","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2022\/08\/una-troballa-incidental-en-biopsies-de-prostata-permet-diagnosticar-una-malaltia-sistemica-no-sospitada-previament\/","title":{"rendered":"Una troballa incidental en bi\u00f2psies de pr\u00f2stata permet diagnosticar una malaltia sist\u00e8mica no sospitada pr\u00e8viament"},"content":{"rendered":"

Les amilo\u00efdosis s\u00f3n un grup de malalties en qu\u00e8 diferents tipus de prote\u00efnes es pleguen anormalment, es dipositen als teixits i n\u2019acaben comprometent la funci\u00f3. Aquests dip\u00f2sits poden ser locals o sist\u00e8mics.<\/p>\n

Tot i ser poc coneguda fa nom\u00e9s 25 anys, actualment es considera que l\u2019amilo\u00efdosi TTR (per dip\u00f2sit de la prote\u00efna Transtiretina)<\/strong> \u00e9s la forma m\u00e9s freq\u00fcent d\u2019amilo\u00efdosi sist\u00e8mica associada a l\u2019envelliment. Abans coneguda com a amilo\u00efdosi card\u00edaca senil, avui sabem que els dip\u00f2sits es poden trobar a diversos \u00f2rgans i teixits, anys abans de que es manifestin s\u00edmptomes card\u00edacs que poden arribar a ser greus.<\/p>\n

El diagn\u00f2stic preco\u00e7 d\u2019aquesta forma d\u2019amilo\u00efdosi sist\u00e8mica \u00e9s dif\u00edcil degut a que els seus principals s\u00edmptomes se superposen i es confonen sovint amb manifestacions habituals de l\u2019envelliment.<\/p>\n

Una recerca liderada per la Dra. Maria Pan\u00e9<\/strong> i el Dr. Enric Condom<\/strong>, del Servei d\u2019Anatomia Patol\u00f2gica de l\u2019HUB i investigadors de l\u2019IDIBELL, i en que tamb\u00e9 han participat els serveis de Radiologia, Urologia i Medicina Interna de l\u2019hospital, ha comprovat que la pr\u00f2stata \u00e9s un dels teixits en qu\u00e8 es diposita amiloide en els casos d\u2019amilo\u00efdosi sist\u00e8mica (especialment de tipus TTR), un fet molt poc conegut fins ara.<\/p>\n

Els autors varen trobar, de manera incidental, m\u00ednims dip\u00f2sits d\u2019amiloide en bi\u00f2psies de pr\u00f2stata de 40 pacients, d\u2019entre milers de bi\u00f2psies practicades per sospita de c\u00e0ncer prost\u00e0tic entre 2001 i 2022. L\u2019estudi immunohistoqu\u00edmic va permetre confirmar la troballa i determinar el tipus d\u2019amiloide en m\u00e9s de 80% dels casos. Molt majorit\u00e0riament corresponia a amiloide TTR. Nom\u00e9s quatre dels pacients comptaven amb un diagn\u00f2stic previ d\u2019amilo\u00efdosi sist\u00e8mica (tots ells no TTR).<\/p>\n

En revisar les hist\u00f2ries cl\u00edniques dels pacients on s\u2019havia detectat dip\u00f2sit d\u2019amiloide, els autors de l\u2019estudi, que ha publicat la revista Histopathology<\/em><\/a>, van comprovar que tots tenien, com a m\u00ednim, un dels s\u00edmptomes descrits com a caracter\u00edstics de l\u2019amilo\u00efdosi sist\u00e8mica TTR: s\u00edndrome del canal carpi\u00e0 bilateral, p\u00e8rdua auditiva i problemes osteoarticulars (tendinopaties, estenosi de canal lumbar, artrosi), entre d\u2019altres.<\/p>\n

Es tracta de\u00a0 la s\u00e8rie m\u00e9s extensa publicada fins ara de pacients en qu\u00e8 es diagnostica amilo\u00efdosi a la pr\u00f2stata. Tal i com explica la Dra. Maria Pan\u00e9<\/strong>, investigadora principal del treball, \u201cl\u2019impacte cl\u00ednic potencial i el benefici que podem obtenir d\u2019aquest diagn\u00f2stic incidental \u00e9s important, perqu\u00e8 un percentatge indeterminat dels pacients amb amilo\u00efdosi sist\u00e8mica TTR acaben desenvolupant una cardiopatia, que si es diagnostica i es tracta preco\u00e7ment, permet una millora significativa en la qualitat de vida i la superviv\u00e8ncia dels pacients<\/em>\u201d.<\/p>\n

A m\u00e9s de fer pal\u00e8s que la pr\u00f2stata \u00e9s un teixit diana per als dip\u00f2sits d\u2019amiloide, el treball de l\u2019HUB tamb\u00e9 pret\u00e9n contribuir a difondre entre els professionals el quadre cl\u00ednic de l\u2019amilo\u00efdosi sist\u00e8mica TTR, que cursa sobretot amb simptomatologia musculoesquel\u00e8tica i neurosensorial i remarcant que no tots els pacients amb aquesta forma d\u2019amilo\u00efdosi tenen afectaci\u00f3 card\u00edaca.<\/p>\n

Addicionalment, es recorda la utilitat de revisar qualsevol mostra de bi\u00f2psia en pacients amb s\u00edmptomes sospitosos d\u2019amilo\u00efdosi sist\u00e8mica, per tal d\u2019intentar detectar dip\u00f2sits d\u2019amiloide que haguessin passat desapercebuts, explica la Dra. Pan\u00e9.<\/p>\n

 <\/p>\n

 <\/p>\n

L\u2019Institut d’Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) \u00e9s un centre de recerca en biomedicina creat l\u2019any 2004. Est\u00e0 participat per l’Hospital Universitari de Bellvitge i l\u2019Hospital de Viladecans de l’Institut Catal\u00e0 de la Salut, l’Institut Catal\u00e0 d’Oncologia, la Universitat de Barcelona i l\u2019Ajuntament de l\u2019Hospitalet de Llobregat.<\/em><\/p>\n

L\u2019IDIBELL \u00e9s membre del Campus d’Excel\u00b7l\u00e8ncia Internacional de la Universitat de Barcelona HUBc i forma part de la instituci\u00f3 CERCA de la Generalitat de Catalunya. L’any 2009 es va convertir en un dels cinc primers centres d\u2019investigaci\u00f3 espanyols acreditats com a institut d\u2019investigaci\u00f3 sanit\u00e0ria per l\u2019Instituto de Salud Carlos III. A m\u00e9s, forma part del programa \u201cHR Excellence in Research\u201d de la Uni\u00f3 Europea i \u00e9s membre de EATRIS i REGIC. Des de l\u2019any 2018, l\u2019IDIBELL \u00e9s un Centro Acreditado de la Fundaci\u00f3n Cient\u00edfica AECC (FCAECC).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

La recerca, liderada per investigadors de l\u2019IDIBELL i l\u2019Hospital Universitari de Bellvitge (HUB), ha establert que quan es detecta incidentalment amilo\u00efdosi a la pr\u00f2stata gaireb\u00e9 sempre es tracta de la variant sist\u00e8mica de tipus TTR de la malaltia, associada a l\u2019envelliment. <\/p>\n","protected":false},"author":8,"featured_media":22075,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[332,395,447,452],"tags":[],"class_list":["post-22046","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cancer","category-mecanismes-de-resistencia-i-progressio-en-el-cancer-de-prostata","category-p-de-mecanismes-molelculars-i-terapia-experimental-en-oncologia-oncobell","category-procure"],"publishpress_future_action":{"enabled":false,"date":"2024-11-12 12:21:52","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/22046"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=22046"}],"version-history":[{"count":1,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/22046\/revisions"}],"predecessor-version":[{"id":22048,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/22046\/revisions\/22048"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/22075"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=22046"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=22046"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=22046"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}