Dr. Manel Esteller<\/strong>, del l’Institut de Recerca contra la Leuc\u00e8mia Josep Carreras (IJC), demostra que existeixen canvis epigen\u00e8tics lligats al desencadenament de MISC, almenys en el grup de la cohort estudiat.<\/p>\nEls resultats de l’estudi, signat per la Dra. Ver\u00f3nica D\u00e1valos<\/strong> i Carlos A. Garc\u00eda-Prieto<\/strong>, van mostrar que hi havia gens espec\u00edfics afectats en els pacients, com els associats a l’activaci\u00f3 dels limf\u00f2cits T, les c\u00e8l\u00b7lules natural killer, el reconeixement d’ant\u00edgens i la coagulaci\u00f3. Aquest patr\u00f3 de desregulaci\u00f3 epigen\u00e8tica tamb\u00e9 es va observar en la s\u00edndrome de Kawasaki, una altra malaltia inflamat\u00f2ria que va arribar al seu punt \u00e0lgid en 2009 i que possiblement est\u00e0 relacionada amb la infecci\u00f3 pel virus de la grip A H1N1.<\/p>\nCuriosament, dos dels 33 esdeveniments de metilaci\u00f3 de l’ADN que defineixen la signatura s\u00f3n tamb\u00e9 caracter\u00edstics en adults sense comorbiditats que desenvolupen la malaltia greu de COVID-19, com es va definir pr\u00e8viament a la signatura EPICOVID trobada pel mateix equip l\u2019any passat. Aquest fet confirma que tots dos processos, el MISC en nens i la S\u00edndrome de dificultat respirat\u00f2ria aguda en adults, s\u00f3n complicacions inflamat\u00f2ries postinfeccioses i podrien ser tractades de forma diferent de la fase inicial de la infecci\u00f3 viral. En aquest sentit, els investigadors plantegen la hip\u00f2tesi que la inhibici\u00f3 farmacol\u00f2gica del gen CUL2, un mediador de la inflamaci\u00f3, podria ser \u00fatil per als pacients amb MISC, ja que se sap que protegeix contra les respostes hiperinflamatorias.<\/p>\n
Es tracta d’una caracter\u00edstica inusual i la Dra. Pujol<\/strong> comenta que “\u00e9s interessant veure que dos trastorns que presenten manifestacions cl\u00edniques similars, el MISC i el Kawasaki, tamb\u00e9 comparteixen una signatura epigen\u00e8tica comuna, que \u00e9s diferent de la signatura epigen\u00e8tica causada per altres virus, incl\u00f2s el VIH<\/em>“. En la mateixa l\u00ednia, el Dr. Esteller<\/strong> conclou que \u201csembla que en ambdues s\u00edndromes, la MISC i la Kawasaki, hi ha una reacci\u00f3 exagerada del sistema immune dels nens davant d’una agressi\u00f3 v\u00edrica. Con\u00e8ixer els mecanismes de totes dues malalties ens donar\u00e0 millors eines per diagnosticar-les i tractar-les<\/em>\u201d.<\/p>\n <\/p>\n
<\/p>\n
L\u2019Institut d’Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) \u00e9s un centre de recerca en biomedicina creat l\u2019any 2004. Est\u00e0 participat per l’Hospital Universitari de Bellvitge i l\u2019Hospital de Viladecans de l’Institut Catal\u00e0 de la Salut, l’Institut Catal\u00e0 d’Oncologia, la Universitat de Barcelona i l\u2019Ajuntament de l\u2019Hospitalet de Llobregat.<\/em><\/p>\nL\u2019IDIBELL \u00e9s membre del Campus d’Excel\u00b7l\u00e8ncia Internacional de la Universitat de Barcelona HUBc i forma part de la instituci\u00f3 CERCA de la Generalitat de Catalunya. L’any 2009 es va convertir en un dels cinc primers centres d\u2019investigaci\u00f3 espanyols acreditats com a institut d\u2019investigaci\u00f3 sanit\u00e0ria per l\u2019Instituto de Salud Carlos III. A m\u00e9s, forma part del programa \u201cHR Excellence in Research\u201d de la Uni\u00f3 Europea i \u00e9s membre de EATRIS i REGIC. Des de l\u2019any 2018, l\u2019IDIBELL \u00e9s un Centro Acreditado de la Fundaci\u00f3n Cient\u00edfica AECC (FCAECC).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"L\u2018equip de la Dra. Aurora Pujol de l\u2019IDIBELL i el Dr. Manel Esteller de l\u2019Institut de Recerca contra la Leuc\u00e8mia Josep Carreras han identificat una signatura epigen\u00e8tica associada a la S\u00edndrome Inflamat\u00f2ria Multisist\u00e8mica en Nens (MISC) que apareix despr\u00e9s de la infecci\u00f3 del virus SARS-CoV-2.<\/p>\n","protected":false},"author":8,"featured_media":21756,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[380,340,457],"tags":[],"class_list":["post-21755","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-malalties-neurometaboliques","category-neurociencies","category-p-de-neurociencies"],"publishpress_future_action":{"enabled":false,"date":"2024-12-01 03:54:56","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/21755","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=21755"}],"version-history":[{"count":1,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/21755\/revisions"}],"predecessor-version":[{"id":21757,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/21755\/revisions\/21757"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/21756"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=21755"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=21755"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=21755"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}