{"id":21725,"date":"2022-06-22T10:00:24","date_gmt":"2022-06-22T08:00:24","guid":{"rendered":"https:\/\/idibell.cat\/?p=21725"},"modified":"2022-06-21T15:34:37","modified_gmt":"2022-06-21T13:34:37","slug":"un-estudi-descriu-una-nova-manera-de-generar-cellules-productores-dinsulina","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2022\/06\/un-estudi-descriu-una-nova-manera-de-generar-cellules-productores-dinsulina\/","title":{"rendered":"Un estudi descriu una nova manera de generar c\u00e8l\u00b7lules productores d’insulina"},"content":{"rendered":"

Els resultats de l’estudi liderat pel Dr. lov Andersson, investigador s\u00e8nior del Departament de Biologia Cel\u00b7lular i Molecular de l’Institut Karolinska han identificat una nova mol\u00e8cula i desxifrat el mecanisme d\u2019acci\u00f3 que fa que aquesta mol\u00e8cula\u00a0 sigui capa\u00e7 d’estimular la formaci\u00f3 de noves c\u00e8l\u00b7lules productores d’insulina com a potencial tractament de la diabetis<\/p>\n

Tant la diabetis tipus 1 com el tipus 2 es caracteritzen per nivells elevats de sucre en sang. Aix\u00f2 pot ser degut a nivells baixos d’insulina end\u00f2gena, l’hormona necess\u00e0ria per a la captaci\u00f3 de glucosa de la sang, o b\u00e9, a una incapacitat fisiol\u00f2gica per utilitzar la insulina secretada, o ambdues. Les injeccions d’insulina i els f\u00e0rmacs que baixen la glucosa poden controlar la malaltia, per\u00f2 no curar-la.<\/p>\n

Una alternativa a aquests f\u00e0rmacs podria ser un tractament que reguli la glucosa en sang augmentant el nombre de c\u00e8l\u00b7lules \u03b2 pancre\u00e0tiques productores d’insulina, per\u00f2 per aix\u00f2 cal controlar la regeneraci\u00f3 d’aquestes c\u00e8l\u00b7lules.<\/p>\n

En estudis previs, l’equip del Karolinska havia descrit una mol\u00e8cula petita capa\u00e7 d’estimular la regeneraci\u00f3 de les c\u00e8l\u00b7lules productores d’insulina. Ho van aconseguir analitzant una \u00e0mplia bateria de mol\u00e8cules en el model de peix zebra. En el present estudi, examinen el mecanisme molecular d’aquesta estimulaci\u00f3.<\/p>\n

Mitjan\u00e7ant l’an\u00e0lisi d’un gran nombre d’interaccions moleculars en c\u00e8l\u00b7lules de llevat, els investigadors han demostrat que la seva mol\u00e8cula s’uneix a una prote\u00efna anomenada MNK2. Estudis posteriors en peix zebra i cultius cel\u00b7lulars indiquen que la mol\u00e8cula funciona regulant la traducci\u00f3 de l’ARNm i potenciant la s\u00edntesi de prote\u00efnes, sense les quals no es pot augmentar la formaci\u00f3 de noves c\u00e8l\u00b7lules \u03b2.<\/p>\n

L’estudi tamb\u00e9 mostra que la mol\u00e8cula pot induir la formaci\u00f3 de noves c\u00e8l\u00b7lules \u03b2 pancre\u00e0tiques de porc i estimular l’expressi\u00f3 d’insulina en organoids humans (formacions cel\u00b7lulars semblants a \u00f2rgans).<\/p>\n

Text adaptat de Institut Karolinska (enlla\u00e7<\/a>)<\/p>\n

 <\/p>\n

L\u2019Institut d’Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) \u00e9s un centre de recerca en biomedicina creat l\u2019any 2004. Est\u00e0 participat per l’Hospital Universitari de Bellvitge i l\u2019Hospital de Viladecans de l’Institut Catal\u00e0 de la Salut, l’Institut Catal\u00e0 d’Oncologia, la Universitat de Barcelona i l\u2019Ajuntament de l\u2019Hospitalet de Llobregat.<\/em><\/p>\n

L\u2019IDIBELL \u00e9s membre del Campus d’Excel\u00b7l\u00e8ncia Internacional de la Universitat de Barcelona HUBc i forma part de la instituci\u00f3 CERCA de la Generalitat de Catalunya. L’any 2009 es va convertir en un dels cinc primers centres d\u2019investigaci\u00f3 espanyols acreditats com a institut d\u2019investigaci\u00f3 sanit\u00e0ria per l\u2019Instituto de Salud Carlos III. A m\u00e9s, forma part del programa \u201cHR Excellence in Research\u201d de la Uni\u00f3 Europea i \u00e9s membre de EATRIS i REGIC. Des de l\u2019any 2018, l\u2019IDIBELL \u00e9s un Centro Acreditado de la Fundaci\u00f3n Cient\u00edfica AECC (FCAECC).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

Investigadors de l’Institut Karolinska de Su\u00e8cia, amb la col\u00b7laboraci\u00f3 de Meritxell Rovira de l’IDIBELL, el P-CMRC i la UB mostren que una mol\u00e8cula recentment identificada estimula la formaci\u00f3 de noves c\u00e8l\u00b7lules productores d’insulina en teixits de peix zebra i mam\u00edfers.<\/p>\n","protected":false},"author":8,"featured_media":21727,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[349,482,489],"tags":[],"class_list":["post-21725","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicina-regenerativa","category-p-de-medicina-regenerativa","category-regeneracio-de-lpancrees-progenitors-pancreatics-i-els-seus-ninxols"],"publishpress_future_action":{"enabled":false,"date":"2024-12-01 01:09:13","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/21725","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=21725"}],"version-history":[{"count":1,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/21725\/revisions"}],"predecessor-version":[{"id":21726,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/21725\/revisions\/21726"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/21727"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=21725"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=21725"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=21725"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}