{"id":21348,"date":"2022-05-10T09:30:46","date_gmt":"2022-05-10T07:30:46","guid":{"rendered":"https:\/\/idibell.cat\/?p=21348"},"modified":"2022-05-10T09:31:36","modified_gmt":"2022-05-10T07:31:36","slug":"presenten-una-nova-proteina-recombinant-que-reverteix-lestat-proinflamatori-de-cellules-de-pacients-amb-lupus","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2022\/05\/presenten-una-nova-proteina-recombinant-que-reverteix-lestat-proinflamatori-de-cellules-de-pacients-amb-lupus\/","title":{"rendered":"Presenten una nova prote\u00efna recombinant que reverteix l&#8217;estat proinflamatori de c\u00e8l\u00b7lules de pacients amb lupus"},"content":{"rendered":"<p>El grup de recerca de l&#8217;IDIBELL liderat pel <strong>Dr. Josep Maria Aran<\/strong> acaba de presentar en un article a la revista <a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.883743\/full\"><em>Frontiers in Immunology<\/em><\/a> una prote\u00efna recombinant amb una prometedora activitat immunomoduladora. <strong>La prote\u00efna en q\u00fcesti\u00f3 \u00e9s capa\u00e7 de fer passar les c\u00e8l\u00b7lules del sistema immunitari d&#8217;un estat proinflamatori a un estat tolerog\u00e8nic i antiinflamatori<\/strong>.<\/p>\n<p>El lupus \u00e9s una malaltia autoimmune en la qual les c\u00e8l\u00b7lules del sistema immunitari ataquen els teixits propis. Aix\u00f2 pot causar danys importants en moltes parts del cos com articulacions, ronyons o pulmons. En aquest estudi els investigadors han demostrat que aquesta prote\u00efna recombinant \u00e9s capa\u00e7 de revertir l&#8217;estat proinflamatori, i, per tant, l&#8217;atac al mateix cos de les c\u00e8l\u00b7lules del sistema immunitari de pacients amb lupus nefritis.<\/p>\n<p>&#8220;<em>Aquesta capacitat de frenar l&#8217;estat proinflamatori de les c\u00e8l\u00b7lules dels pacients amb lupus posa en evidencia el <strong>gran potencial terap\u00e8utic<\/strong> d&#8217;aquesta prote\u00efna recombinant pel tractament del lupus i per altres malalties autoimmunit\u00e0ries<\/em>&#8220;, afirma el <strong>Dr. Aran<\/strong>.<\/p>\n<p>La prote\u00efna recombinant que han desenvolupat \u00e9s una reestructuraci\u00f3 d&#8217;una prote\u00efna reguladora del sistema immunitari innat, la primera l\u00ednia de defensa del nostre cos. Els investigadors han identificat i reorganitzat els dominis necessaris d&#8217;aquesta prote\u00efna reguladora per a aconseguir l&#8217;efecte modulador desitjat evitant l&#8217;activitat col\u00b7lateral no desitjada de la prote\u00efna original.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><em>L\u2019Institut d&#8217;Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) \u00e9s un centre de recerca en biomedicina creat l\u2019any 2004. Est\u00e0 participat per l&#8217;Hospital Universitari de Bellvitge i l\u2019Hospital de Viladecans de l&#8217;Institut Catal\u00e0 de la Salut, l&#8217;Institut Catal\u00e0 d&#8217;Oncologia, la Universitat de Barcelona i l\u2019Ajuntament de l\u2019Hospitalet de Llobregat.<\/em><\/p>\n<p><em>L\u2019IDIBELL \u00e9s membre del Campus d&#8217;Excel\u00b7l\u00e8ncia Internacional de la Universitat de Barcelona HUBc i forma part de la instituci\u00f3 CERCA de la Generalitat de Catalunya. L&#8217;any 2009 es va convertir en un dels cinc primers centres d\u2019investigaci\u00f3 espanyols acreditats com a institut d\u2019investigaci\u00f3 sanit\u00e0ria per l\u2019Instituto de Salud Carlos III. A m\u00e9s, forma part del programa \u201cHR Excellence in Research\u201d de la Uni\u00f3 Europea i \u00e9s membre de EATRIS i REGIC. Des de l\u2019any 2018, l\u2019IDIBELL \u00e9s un Centro Acreditado de la Fundaci\u00f3n Cient\u00edfica AECC (FCAECC).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>La prote\u00efna en q\u00fcesti\u00f3 \u00e9s capa\u00e7 de frenar l&#8217;activitat proinflamat\u00f2ria de les c\u00e8l\u00b7lules del sistema immunitari, i, per tant, aturar l&#8217;atac d&#8217;aquestes al mateix cos.<\/p>\n","protected":false},"author":8,"featured_media":21349,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[334,464,378],"tags":[],"class_list":["post-21348","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicina-translacional","category-p-de-gens-malaltia-i-terapia","category-processos-immune-inflamatoris-i-terapia-genica"],"publishpress_future_action":{"enabled":false,"date":"2024-12-25 09:58:10","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/21348","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=21348"}],"version-history":[{"count":1,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/21348\/revisions"}],"predecessor-version":[{"id":21350,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/21348\/revisions\/21350"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/21349"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=21348"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=21348"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=21348"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}