{"id":20999,"date":"2022-03-30T10:56:54","date_gmt":"2022-03-30T08:56:54","guid":{"rendered":"https:\/\/idibell.cat\/?p=20999"},"modified":"2022-03-30T10:57:33","modified_gmt":"2022-03-30T08:57:33","slug":"un-estudi-demostra-que-el-patogen-h-influenzae-tipus-f-es-molt-estable-geneticament","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2022\/03\/un-estudi-demostra-que-el-patogen-h-influenzae-tipus-f-es-molt-estable-geneticament\/","title":{"rendered":"Un estudi demostra que el patogen H. influenzae tipus f \u00e9s molt estable gen\u00e8ticament"},"content":{"rendered":"<p><em>Haemophilus influenzae<\/em> \u00e9s un bacteri patogen important que colonitza el tracte respiratori hum\u00e0. Aquest bacteri pot estar envoltat d&#8217;una c\u00e0psula de sucres, un destacat factor de virul\u00e8ncia que divideix les soques de <em>H. influenzae<\/em> en dos grups, encapsulats i no encapsulats. Dins aquest segon grup s&#8217;han distingit sis serotips (a-f) en funci\u00f3 de la composici\u00f3 dels seus sucres.<\/p>\n<p>Afortunadament, la introducci\u00f3 de la vacuna contra el serotip b, associat a meningitis en nens, va canviar l&#8217;epidemiologia d&#8217;aquest bacteri. No obstant aix\u00f2, amb la pr\u00e0ctica desaparici\u00f3 del serotip b, els <em>H. influenzae<\/em> no encapsulats s\u00f3n actualment el principal agent associat a malalties, seguit per bacteris encapsulats del serotip f.<\/p>\n<p>Recentment, un treball publicat a la revista <a href=\"https:\/\/www.nature.com\/articles\/s41598-022-07185-5#Sec7\"><em>Scientifc Reports<\/em><\/a>, realitzat pel grup de recerca en Epidemiologia Bacteriana de l&#8217;IDIBELL, l&#8217;Hospital de Bellvitge i CIBERES, ha estudiat la diversitat de gens presents en les soques cl\u00edniques de <em>H. influenzae<\/em> serotip f.<\/p>\n<p>Tots els a\u00efllats del serotip f analitzats en aquest estudi pertanyien a un \u00fanic clon que presentava un nombre molt redu\u00eft de variacions gen\u00e8tiques i una alta taxa d&#8217;estabilitat del seu genoma, fins i tot m\u00e9s que altres serotips encapsulats. Tots els bacteris utilitzats procedien d&#8217;un estudi multic\u00e8ntric internacional que inclou l&#8217;IDIBELL i l&#8217;Hospital Universitari de Bellvitge m\u00e9s els centres de refer\u00e8ncia d&#8217;aquest bacteri de Portugal i els Pa\u00efsos Baixos.<\/p>\n<p>Les <strong>Dres. Aida Gonz\u00e1lez i Sara Mart\u00ed<\/strong>, l\u00edders del projecte, comenten que &#8220;<em>l&#8217;homogene\u00eftat gen\u00e8tica del serotip f podria explicar la seva expansi\u00f3 clonal elevada. Si b\u00e9 \u00e9s cert que les soques encapsulades de H. influenzae presenten alta homogene\u00eftat gen\u00f2mica en contraposici\u00f3 a les no encapsulades, aquesta difer\u00e8ncia podria ser deguda a la mateixa c\u00e0psula, que podria actuar com una barrera f\u00edsica reduint els nivells de recombinaci\u00f3 o la seva menor pres\u00e8ncia com colonitzadores dificultant la interacci\u00f3 amb altres microorganismes<\/em>&#8220;.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><em>L\u2019Institut d&#8217;Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) \u00e9s un centre de recerca en biomedicina creat l\u2019any 2004. Est\u00e0 participat per l&#8217;Hospital Universitari de Bellvitge i l\u2019Hospital de Viladecans de l&#8217;Institut Catal\u00e0 de la Salut, l&#8217;Institut Catal\u00e0 d&#8217;Oncologia, la Universitat de Barcelona i l\u2019Ajuntament de l\u2019Hospitalet de Llobregat.<\/em><\/p>\n<p><em>L\u2019IDIBELL \u00e9s membre del Campus d&#8217;Excel\u00b7l\u00e8ncia Internacional de la Universitat de Barcelona HUBc i forma part de la instituci\u00f3 CERCA de la Generalitat de Catalunya. L&#8217;any 2009 es va convertir en un dels cinc primers centres d\u2019investigaci\u00f3 espanyols acreditats com a institut d\u2019investigaci\u00f3 sanit\u00e0ria per l\u2019Instituto de Salud Carlos III. A m\u00e9s, forma part del programa \u201cHR Excellence in Research\u201d de la Uni\u00f3 Europea i \u00e9s membre de EATRIS i REGIC. Des de l\u2019any 2018, l\u2019IDIBELL \u00e9s un Centro Acreditado de la Fundaci\u00f3n Cient\u00edfica AECC (FCAECC).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un treball publicat a la revista Scientifc Reports, realitzat pel grup de recerca en Epidemiologia Bacteriana de l&#8217;IDIBELL, l&#8217;Hospital de Bellvitge i CIBERES, ha estudiat la diversitat de gens presents en les soques cl\u00edniques de H. influenzae serotip f.<\/p>\n","protected":false},"author":8,"featured_media":21000,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[480,334,479],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-04 12:18:58","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/20999"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=20999"}],"version-history":[{"count":1,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/20999\/revisions"}],"predecessor-version":[{"id":21001,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/20999\/revisions\/21001"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/21000"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=20999"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=20999"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=20999"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}