La ter\u00e0pia antiangiog\u00e8nica \u00e9s una de les principals estrat\u00e8gies contra els tumors s\u00f2lids. Aquesta ter\u00e0pia inhibeixen la formaci\u00f3 de vasos sanguinis en els tumors, reduint aix\u00ed el subministrament d\u2019oxigen i nutrients, i en conseq\u00fc\u00e8ncia reduint el creixement tumoral. No obstant, aquest estrat\u00e8gia terap\u00e8utica presenta certes limitacions, ja que en algunes ocasions, produeix un augment de l\u2019agressivitat dels tumors, i per tant, de les met\u00e0stasis. Con\u00e8ixer les bases biol\u00f2giques i moleculars que porten els tumors a augmentar la seva agressivitat \u00e9s b\u00e0sic per predir com i quan la ter\u00e0pia antiangiog\u00e8nica funcionar\u00e0, i m\u00e9s important, millorar-ne la seva efic\u00e0cia per ampliar la superviv\u00e8ncia dels pacients.<\/p>\n
Les c\u00e8l\u00b7lules canceroses no nom\u00e9s formen una massa tumoral de c\u00e8l\u00b7lules mutades que es divideixen descontroladament. En realitat, formen part d\u2019un ecosistema molt complex format per diferents tipus cel\u00b7lulars<\/strong> que treballen i es comuniquen de maneres conjunta dins d\u2019una matriu extracel\u00b7lular que les aguanta i protegeix. Tot aquest conjunt de c\u00e8l\u00b7lules i mol\u00e8cules complexes \u00e9s el que anomenem microambient tumoral.<\/p>\n La formaci\u00f3 i progressi\u00f3 de tumors est\u00e0 estretament lligada a la interacci\u00f3 entre els diferents components que formen el microambient tumoral, i un dels actors principals dins aquest ecosistema \u00e9s la angiog\u00e8nesi, la formaci\u00f3 de vasos sanguinis. Felix Peix<\/strong> i Oriol Casanovas<\/strong>, cap del grup de recerca en Angiog\u00e8nesi Tumoral<\/a> de l\u2019IDIBELL i de l\u2019ICO, acaben de publicar un article a la revista Seminars in Cancer Biology<\/em> <\/a>\u00a0que repassa tot el que es coneix sobre com la remodelaci\u00f3 del microamibient tumoral per part de la ter\u00e0pia antiangiog\u00e8nica podria ser l\u2019instigadora del augment de la agressivitat tumoral.<\/p>\n L\u2019article repassa com els antiangiog\u00e8nics produeixen hip\u00f2xia, estr\u00e8s mec\u00e0nic i acidificaci\u00f3 del microambient tumoral, i com tots aquets canvis s\u00f3n detectats per les c\u00e8l\u00b7lules tumorals a partir de receptors de superf\u00edcie. En conseq\u00fc\u00e8ncia, aquets receptors inicien casades de senyalitzaci\u00f3 per induir canvis en les c\u00e8l\u00b7lules tumorals<\/strong> que les ajudin adaptar-se en aquest nou ambient.<\/p>\n Felix Peix<\/strong> i Oriol Casanovas<\/strong> declaren: \u201cUtilitzar ter\u00e0pies que bloquegin l\u2019acci\u00f3 d\u2019aquets receptors i sensors cel\u00b7lulars podria resultat un tractament molt efectiu per prevenir que les c\u00e8l\u00b7lules tumorals augmentin la seva agressivitat despr\u00e9s de la ter\u00e0pia antiangiog\u00e8nica<\/em>\u201d.<\/p>\n <\/p>\n <\/p>\n L\u2019Institut d’Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) \u00e9s un centre de recerca en biomedicina creat l\u2019any 2004. Est\u00e0 participat per l’Hospital Universitari de Bellvitge i l\u2019Hospital de Viladecans de l’Institut Catal\u00e0 de la Salut, l’Institut Catal\u00e0 d’Oncologia, la Universitat de Barcelona i l\u2019Ajuntament de l\u2019Hospitalet de Llobregat.<\/em><\/p>\n L\u2019IDIBELL \u00e9s membre del Campus d’Excel\u00b7l\u00e8ncia Internacional de la Universitat de Barcelona HUBc i forma part de la instituci\u00f3 CERCA de la Generalitat de Catalunya. L’any 2009 es va convertir en un dels cinc primers centres d\u2019investigaci\u00f3 espanyols acreditats com a institut d\u2019investigaci\u00f3 sanit\u00e0ria per l\u2019Instituto de Salud Carlos III. A m\u00e9s, forma part del programa \u201cHR Excellence in Research\u201d de la Uni\u00f3 Europea i \u00e9s membre de EATRIS i REGIC. Des de l\u2019any 2018, l\u2019IDIBELL \u00e9s un Centro Acreditado de la Fundaci\u00f3n Cient\u00edfica AECC (FCAECC).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":" Un article del grup de recerca en Angiog\u00e8nesi Tumoral de l\u2019IDIBELL i de l\u2019ICO repassa els mecanismes implicats en l\u2019increment de malignitat tumoral que pot provocar la ter\u00e0pia antiangiog\u00e8nica.<\/p>\n","protected":false},"author":8,"featured_media":20993,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[397,332,447,452],"tags":[],"class_list":["post-20991","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-angiogenesi-tumoral","category-cancer","category-p-de-mecanismes-molelculars-i-terapia-experimental-en-oncologia-oncobell","category-procure"],"publishpress_future_action":{"enabled":false,"date":"2024-12-10 18:17:43","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/20991","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=20991"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/20991\/revisions"}],"predecessor-version":[{"id":20996,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/20991\/revisions\/20996"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/20993"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=20991"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=20991"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=20991"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}