{"id":20578,"date":"2022-02-22T09:28:34","date_gmt":"2022-02-22T08:28:34","guid":{"rendered":"https:\/\/idibell.cat\/?p=20578"},"modified":"2022-02-22T09:28:34","modified_gmt":"2022-02-22T08:28:34","slug":"la-generacio-dun-model-de-neurofibroma-a-partir-de-cellules-mare-obre-la-porta-al-desenvolupament-de-nous-tractaments","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2022\/02\/la-generacio-dun-model-de-neurofibroma-a-partir-de-cellules-mare-obre-la-porta-al-desenvolupament-de-nous-tractaments\/","title":{"rendered":"La generaci\u00f3 d\u2019un model de neurofibroma a partir de c\u00e8l\u00b7lules mare obre la porta al desenvolupament de nous tractaments"},"content":{"rendered":"<p>Un treball publicat a la revista <em><a href=\"https:\/\/www.cell.com\/cell-reports\/fulltext\/S2211-1247(22)00106-1\">Cell Reports<\/a> <\/em>descriu el desenvolupament d&#8217;un nou sistema basat en c\u00e8l\u00b7lules mare per generar neurofibromes, tumors del sistema nervi\u00f3s perif\u00e8ric. Aquests tumors es desenvolupen en persones que tenen una malaltia heredit\u00e0ria molt prevalent, 1 de cada 3000 persones, anomenada Neurofibromatosis de tipus 1, i constitueixen la causa principal de mortalitat entre aquests pacients.<\/p>\n<p>Fins ara, mancava un model robust de neurofibromes humans en ratolins on poder provar nous tractaments. Aquest treball, que ha comptat amb la participaci\u00f3 d&#8217;investigadors del programa de medicina regenerativa de l&#8217;IDIBELL i el P-CMRC, investigadors del programa d&#8217;investigaci\u00f3 en c\u00e0ncer Oncobell de l&#8217;IDIBELL i de l&#8217;ICO, i que ha estat liderat pel grup de C\u00e0ncer Hereditari de l&#8217;IGTP, representa <strong>un salt important en la modelitzaci\u00f3 d&#8217;aquests tumors<\/strong>.<\/p>\n<p>L&#8217;originalitat del treball recau en la utilitzaci\u00f3 d&#8217;un sistema de cultiu 3D, compost per c\u00e8l\u00b7lules de Schwann, derivades de c\u00e8l\u00b7lules mare humanes, i fibroblasts, isolats dels tumors dels pacients, els dos tipus cel\u00b7lulars principals dels neurofibromes. L&#8217;avantatge que ofereix aquest nou model \u00e9s que se&#8217;n poden generar moltes esferes, i per tant, <strong>permeten avaluar m\u00faltiples f\u00e0rmacs al mateix temps<\/strong>. A m\u00e9s, quan aquestes esferes s&#8217;implanten en el nervi ci\u00e0tic d&#8217;un ratol\u00ed, s\u00f3n capaces de generar neurofibromes humans, demostrant que representen un model fidedigne.<\/p>\n<p>Finalment, a partir de neurofibromes de pacients tamb\u00e9 se n&#8217;ha estudiat l&#8217;heterogene\u00eftat cel\u00b7lular a partir de l&#8217;an\u00e0lisi de c\u00e8l\u00b7lula \u00fanica. Aix\u00f2 ha perm\u00e8s disposar d&#8217;una radiografia m\u00e9s clara i completa de la composici\u00f3 cel\u00b7lular d&#8217;aquest tipus de tumors, ajudant a entendre millor aquests tumors i a dissenyar nous potencials f\u00e0rmacs.<\/p>\n<p>Aquest treball tamb\u00e9 ha comptat amb la participaci\u00f3 del Centre de Regulaci\u00f3 Gen\u00f2mica (CRG-CNAG) i el Servei d&#8217;Anatomia Patol\u00f2gica de l&#8217;Hospital de la Vall d&#8217;Hebron.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><em>L\u2019Institut d&#8217;Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) \u00e9s un centre de recerca en biomedicina creat l\u2019any 2004. Est\u00e0 participat per l&#8217;Hospital Universitari de Bellvitge i l\u2019Hospital de Viladecans de l&#8217;Institut Catal\u00e0 de la Salut, l&#8217;Institut Catal\u00e0 d&#8217;Oncologia, la Universitat de Barcelona i l\u2019Ajuntament de l\u2019Hospitalet de Llobregat.<\/em><\/p>\n<p><em>L\u2019IDIBELL \u00e9s membre del Campus d&#8217;Excel\u00b7l\u00e8ncia Internacional de la Universitat de Barcelona HUBc i forma part de la instituci\u00f3 CERCA de la Generalitat de Catalunya. L&#8217;any 2009 es va convertir en un dels cinc primers centres d\u2019investigaci\u00f3 espanyols acreditats com a institut d\u2019investigaci\u00f3 sanit\u00e0ria per l\u2019Instituto de Salud Carlos III. A m\u00e9s, forma part del programa \u201cHR Excellence in Research\u201d de la Uni\u00f3 Europea i \u00e9s membre de EATRIS i REGIC. Des de l\u2019any 2018, l\u2019IDIBELL \u00e9s un Centro Acreditado de la Fundaci\u00f3n Cient\u00edfica AECC (FCAECC).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Els neurofibromes s\u00f3n tumors del sistema nervi\u00f3s perif\u00e8ric, que desenvolupen persones amb una malaltia heredit\u00e0ria, i que suposen la principal causa de mort entre les persones que el pateixen.<\/p>\n","protected":false},"author":8,"featured_media":20579,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[332,417,349,447,482,483,452,346],"tags":[],"class_list":["post-20578","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cancer","category-cancer-hereditari-noticies","category-medicina-regenerativa","category-p-de-mecanismes-molelculars-i-terapia-experimental-en-oncologia-oncobell","category-p-de-medicina-regenerativa","category-potencia-de-cellules-mare","category-procure","category-quimioresistencia-tumoral-i-estromal"],"publishpress_future_action":{"enabled":false,"date":"2024-12-25 05:31:59","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/20578","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=20578"}],"version-history":[{"count":1,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/20578\/revisions"}],"predecessor-version":[{"id":20580,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/20578\/revisions\/20580"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/20579"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=20578"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=20578"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=20578"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}