{"id":20509,"date":"2022-02-16T09:00:48","date_gmt":"2022-02-16T08:00:48","guid":{"rendered":"https:\/\/idibell.cat\/?p=20509"},"modified":"2022-02-16T09:34:57","modified_gmt":"2022-02-16T08:34:57","slug":"un-model-de-cuc-permet-estudiar-els-efectes-adversos-de-la-quimioterapia-mes-comuna-contra-els-tumors-solids-i-millorar-ne-lefectivitat","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2022\/02\/un-model-de-cuc-permet-estudiar-els-efectes-adversos-de-la-quimioterapia-mes-comuna-contra-els-tumors-solids-i-millorar-ne-lefectivitat\/","title":{"rendered":"Un model de cuc permet estudiar els efectes adversos de la quimioter\u00e0pia m\u00e9s comuna contra els tumors s\u00f2lids i millorar-ne l’efectivitat"},"content":{"rendered":"

La quimioter\u00e0pia amb cisplat\u00ed \u00e9s la m\u00e9s comuna per abordar els tumors s\u00f2lids. No obstant aix\u00f2, malgrat la seva efic\u00e0cia, els efectes adversos associats, especialment el potencial neurot\u00f2xic, i les resist\u00e8ncies al tractament que poden desenvolupar les c\u00e8l\u00b7lules tumorals fan augmentar el frac\u00e0s de la ter\u00e0pia i, en conseq\u00fc\u00e8ncia, la mortalitat.<\/p>\n

Ara un grup d’investigadors de l’IDIBELL i de l’ICO han fet servir un model de cuc per estudiar els mecanismes d’adquisici\u00f3 de resist\u00e8ncia al tractament i cercar noves vies per evitar-ho<\/strong>.<\/p>\n

El treball, publicat a la revista Disease Models & Mechanisms<\/em><\/a>, ha estat liderat pel Dr. Juli\u00e1n Cer\u00f3n<\/strong>, de l’IDIBELL, i el Dr. Ernest Nadal<\/strong>, de l’IDIBELL i de l’ICO, amb la col\u00b7laboraci\u00f3 del Dr. Alberto Villanueva<\/strong>, de la mateixa instituci\u00f3. En ell es descriu que una dieta rica en glucosa fa els cucs m\u00e9s sensibles al cisplat\u00ed. A m\u00e9s, mostren que el tractament amb dopamina protegeix de l’efecte neurot\u00f2xic de la quimioter\u00e0pia al model animal.<\/p>\n

Moltes vegades els onc\u00f2legs es veuen obligats a reduir la dosi o fins i tot aturar el tractament amb cisplat\u00ed a causa de la seva toxicitat. “Els nostres resultats suggereixen explorar l’\u00fas de dopamina o derivats per mitigar els efectes neurot\u00f2xics d’aquesta quimioter\u00e0pia. Aix\u00f2 permetria mantenir les dosis desitjades de cisplat\u00ed i augmentar l’efic\u00e0cia del tractament contra els tumors s\u00f2lids<\/em>“, afirma la Dra. Carmen Mart\u00ednez-Fern\u00e1ndez<\/strong>, primera autora del treball.<\/p>\n

 <\/p>\n

El cuc per estudiar una malaltia humana<\/h3>\n

El cuc de terra C. elegans<\/em> \u00e9s \u00e0mpliament utilitzat en la investigaci\u00f3 biom\u00e8dica perqu\u00e8, tot i ser molt simple i petit, t\u00e9 la majoria de les estructures dels animals m\u00e9s complexos i comparteix moltes de les vies metab\u00f2liques. A m\u00e9s, un 40% del seu genoma compr\u00e8n gens hom\u00f2legs als humans.<\/p>\n

La manipulaci\u00f3 del genoma per la tecnologia CRISPR en aquest organisme permet crear models per estudiar malalties m\u00e9s r\u00e0pidament que altres models animals. Tot plegat, unit a altres trets com la transpar\u00e8ncia del seu cos, un curt cicle de vida, i un baix cost de manteniment, el converteix en una eina ideal per a la investigaci\u00f3 biom\u00e8dica.<\/p>\n

“Les caracter\u00edstiques del model C. elegans ens han perm\u00e8s investigar en un organisme pluricel\u00b7lular la resposta al tractament amb cisplat\u00ed, cosa que ens aporta una visi\u00f3 m\u00e9s global i sist\u00e8mica dels seus efectes<\/em>“, afirma el Dr. Cer\u00f3n<\/strong>.<\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

L\u2019Institut d’Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) \u00e9s un centre de recerca en biomedicina creat l\u2019any 2004. Est\u00e0 participat per l’Hospital Universitari de Bellvitge i l\u2019Hospital de Viladecans de l’Institut Catal\u00e0 de la Salut, l’Institut Catal\u00e0 d’Oncologia, la Universitat de Barcelona i l\u2019Ajuntament de l\u2019Hospitalet de Llobregat.<\/em><\/p>\n

L\u2019IDIBELL \u00e9s membre del Campus d’Excel\u00b7l\u00e8ncia Internacional de la Universitat de Barcelona HUBc i forma part de la instituci\u00f3 CERCA de la Generalitat de Catalunya. L’any 2009 es va convertir en un dels cinc primers centres d\u2019investigaci\u00f3 espanyols acreditats com a institut d\u2019investigaci\u00f3 sanit\u00e0ria per l\u2019Instituto de Salud Carlos III. A m\u00e9s, forma part del programa \u201cHR Excellence in Research\u201d de la Uni\u00f3 Europea i \u00e9s membre de EATRIS i REGIC. Des de l\u2019any 2018, l\u2019IDIBELL \u00e9s un Centro Acreditado de la Fundaci\u00f3n Cient\u00edfica AECC (FCAECC).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

Fent servir com a model el cuc de terra C. elegans, un grup d’investigadors de l’IDIBELL i de l’ICO, han demostrat que la dieta rica en glucosa accentua l’efecte del cisplat\u00ed i que la dopamina protegeix davant dels efectes neurot\u00f2xics de la droga.<\/p>\n","protected":false},"author":8,"featured_media":20510,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[332,334,355,464,447,333],"tags":[],"class_list":["post-20509","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cancer","category-medicina-translacional","category-models-de-malaltia-en-c-elegans","category-p-de-gens-malaltia-i-terapia","category-p-de-mecanismes-molelculars-i-terapia-experimental-en-oncologia-oncobell","category-metabolisme-i-mort-cellular"],"publishpress_future_action":{"enabled":false,"date":"2024-12-29 17:33:36","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/20509","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=20509"}],"version-history":[{"count":1,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/20509\/revisions"}],"predecessor-version":[{"id":20511,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/20509\/revisions\/20511"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/20510"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=20509"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=20509"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=20509"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}