{"id":20469,"date":"2022-02-10T12:18:11","date_gmt":"2022-02-10T11:18:11","guid":{"rendered":"https:\/\/idibell.cat\/?p=20469"},"modified":"2022-02-10T12:18:11","modified_gmt":"2022-02-10T11:18:11","slug":"el-tractament-amb-plasma-convalescent-contra-la-covid-19-no-es-efectiu","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2022\/02\/el-tractament-amb-plasma-convalescent-contra-la-covid-19-no-es-efectiu\/","title":{"rendered":"El tractament amb plasma convalescent contra la COVID-19 no \u00e9s efectiu"},"content":{"rendered":"

Un assaig cl\u00ednic amb la participaci\u00f3 de l\u2019IDIBELL i l\u2019Hospital Universitari de Bellvitge, impulsat per la Fundaci\u00f3 Lluita contra la Sida i l\u2019Hospital Universitari Germans Trias i Pujol, ha concl\u00f2s que l\u2019administraci\u00f3 de plasma convalescent amb t\u00edtols alts d\u2019anticossos a pacients amb COVID-19 lleu en els primers 7 dies des de l\u2019inici de s\u00edmptomes no redueix la progressi\u00f3 a malaltia greu i hospitalitzaci\u00f3. Tampoc t\u00e9 un efecte sobre la c\u00e0rrega viral en els pacients que s\u2019han sotm\u00e8s al tractament.<\/p>\n

El plasma convalescent \u00e9s un tipus d\u2019immunoter\u00e0pia passiva<\/strong>, \u00e9s a dir que s\u2019administra directament anticossos al pacient, a difer\u00e8ncia de la vacunaci\u00f3 o immunoter\u00e0pia activa en que s\u2019estimula a l\u2019organisme hum\u00e0 a produir anticossos. El cost relativament baix i la producci\u00f3 senzilla de plasma convalescent van donar lloc al seu \u00fas generalitzat a Europa i sobretot als Estats Units.<\/p>\n

Els resultats de l\u2019assaig cl\u00ednic aleatoritzat s\u2019han publicat a la revista Lancet Respiratory Medicine<\/em><\/a>. L\u2019estudi ha comptat amb la participaci\u00f3 de 376 voluntaris no hospitalitzats de la regi\u00f3 Metropolitana Nord i Metropolitana Sud de Barcelona i de la Catalunya Central. A la meitat d\u2019ells se\u2019ls va administrar una infusi\u00f3 intravenosa de plasma convalescent i la resta de participants van rebre una infusi\u00f3 de s\u00e8rum sal\u00ed com a subst\u00e0ncia placebo. A totes les persones participants se\u2019ls va fer un seguiment m\u00e8dic durant 60 dies i es va demostrar que no hi havia difer\u00e8ncies significatives en la taxa d\u2019hospitalitzaci\u00f3 entre el grup experimental (22 de 188 participants, 12%) i el grup control (21 de 188 participants, 11%). Tampoc es van veure difer\u00e8ncies entre els grups quant a la reducci\u00f3 de la c\u00e0rrega viral als 7 dies, <\/strong>en la durada dels s\u00edmptomes, la necessitat d\u2019ingr\u00e9s a l\u2019UCI, ni els par\u00e0metres inflamatoris pron\u00f2stics en sang. El reclutament de pacients va tenir lloc des de novembre de 2020 fins a maig de 2021, amb seguiment fins al juliol de 2021.<\/p>\n

Els investigadors de l\u2019estudi han afirmat que \u201cels resultats d\u2019aquest estudi no descarten definitivament l\u2019\u00fas d\u2019aquesta ter\u00e0pia que encara podria ser efectiva si es millora la dosis i l\u2019afinitat dels anticossos i els procediments per processar el producte. Per una banda, un producte amb major quantitat d\u2019anticossos, i que aquests fossin espec\u00edfics per a la variant circulant podria incrementar l\u2019efic\u00e0cia. Per altra banda, el plasma a Catalunya se sotmet a un proc\u00e9s d\u2019inactivaci\u00f3 de pat\u00f2gens amb blau de metil\u00e8 que podria degradar els anticossos, i per tant \u00e9s necessari un canvi en el processament per assegurar-ne la integritat\u201d.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

L\u2019estudi demostra que no hi ha difer\u00e8ncies a l\u2019hora de presentar complicacions que requereixin hospitalitzaci\u00f3 entre les persones amb COVID-19 que van rebre la infusi\u00f3 endovenosa de plasma i les que no la van rebre.<\/p>\n","protected":false},"author":8,"featured_media":20483,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[340,344,457],"tags":[],"class_list":["post-20469","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-neurociencies","category-neurofarmacologia-i-dolor","category-p-de-neurociencies"],"publishpress_future_action":{"enabled":false,"date":"2025-03-01 16:07:08","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/20469","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=20469"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/20469\/revisions"}],"predecessor-version":[{"id":20484,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/20469\/revisions\/20484"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/20483"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=20469"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=20469"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=20469"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}