{"id":20321,"date":"2022-01-05T16:52:56","date_gmt":"2022-01-05T15:52:56","guid":{"rendered":"https:\/\/idibell.cat\/?p=20321"},"modified":"2022-01-27T16:30:40","modified_gmt":"2022-01-27T15:30:40","slug":"quines-raons-genetiques-hi-ha-darrere-la-resistencia-al-covid-19","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2022\/01\/quines-raons-genetiques-hi-ha-darrere-la-resistencia-al-covid-19\/","title":{"rendered":"Quines raons gen\u00e8tiques hi ha darrere la resist\u00e8ncia al COVID-19?"},"content":{"rendered":"<p>Est\u00e0 comprovat que la infecci\u00f3 per SARS-CoV-2 es manifesta de formes molt diferents: alguns casos simplement mostren un malestar lleu durant pocs dies, altres han d\u2019ingressar a la UCI i d\u2019altres fins i tot la passen sense experimentar cap mena de s\u00edmptoma. Tamb\u00e9 hi ha casos, per\u00f2, que tot i haver estat convisquent amb persones infectades, no arriben ni tan sols a contagiar-se: <strong>\u00a0el virus no pot entrar al seu cos i, per tant, no hi ha infecci\u00f3 ni resposta immunit\u00e0ria<\/strong>. Descobrir quin \u00e9s aquest mecanisme de protecci\u00f3 pot ajudar a dissenyar tractaments farmacol\u00f2gics que ajudin a combatre, o fins i tot evitar, la infecci\u00f3.<\/p>\n<p>Un estudi internacional on hi participen m\u00e9s de 40 centres de recerca de tot el m\u00f3n, entre ells l\u2019IDIBELL, busca si aquestes persones tenen alguna <strong>particularitat gen\u00e8tica que les fa resistents a la infecci\u00f3<\/strong>. La proposta del projecte ha estat publicada a la revista <em>Nature Immunology<\/em>. Els requisits per participar a l\u2019estudi s\u00f3n haver conviscut amb una persona infectada almenys 5 dies, tenint contacte estret durant un m\u00ednim d\u2019una hora al dia, sense utilitzar mascareta ni cap altra mesura de protecci\u00f3. A m\u00e9s, el candidat ha de tenir un test PCR negatiu seguit d\u2019una prova d\u2019anticossos negativa durant les quatre setmanes posteriors, tot aix\u00f2 acompanyat d\u2019un test PCR positiu de la persona infectada. Als participants se\u2019ls pren una mostra de sang o saliva, a trav\u00e9s de la qual es seq\u00fcencia l\u2019ADN per tal de trobar difer\u00e8ncies respecte les persones que han patit la infecci\u00f3.<\/p>\n<p>Una de les hip\u00f2tesis \u00e9s que hi hagi una mutaci\u00f3 a la prote\u00efna que el virus reconeix per entrar a la c\u00e8l\u00b7lula. \u201c<em>Aix\u00f2 faria que <strong>el virus no pugui entrar a la c\u00e8l\u00b7lula<\/strong>.<\/em>\u201d explica la <strong>Dra Aurora Pujol<\/strong>, metge genetista, professora ICREA i cap del grup de recerca en <a href=\"https:\/\/idibell.cat\/recerca\/area-de-neurociencies\/programa-de-neurociencies\/malalties-neurometaboliques\/\">Malalties Neurometab\u00f2liques<\/a> de l\u2019IDIBELL. \u201c<em>El virus t\u00e9 prote\u00efnes que li funcionen per entrar a les c\u00e8l\u00b7lules de la gran majoria de persones, excepte en aquests casos, on no podria infectar i per tant no hi ha cap mena de resposta immunit\u00e0ria<\/em>\u201d.<\/p>\n<p>Des del principi de l\u2019estudi hi ha hagut un allau de persones candidates, per\u00f2 a hores d\u2019ara <strong>ja s\u2019han reclutat tots els participants necessaris<\/strong>, m\u00e9s de 3.000, i comencen a analitzar dades. La ci\u00e8ncia est\u00e0 avan\u00e7ant a gran velocitat, per tant, es creu que podrem veure resultats en q\u00fcesti\u00f3 de mesos o pocs anys.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><em>L\u2019Institut d&#8217;Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) \u00e9s un centre de recerca en biomedicina creat l\u2019any 2004. Est\u00e0 participat per l&#8217;Hospital Universitari de Bellvitge i l\u2019Hospital de Viladecans de l&#8217;Institut Catal\u00e0 de la Salut, l&#8217;Institut Catal\u00e0 d&#8217;Oncologia, la Universitat de Barcelona i l\u2019Ajuntament de l\u2019Hospitalet de Llobregat.<\/em><\/p>\n<p><em>L\u2019IDIBELL \u00e9s membre del Campus d&#8217;Excel\u00b7l\u00e8ncia Internacional de la Universitat de Barcelona HUBc i forma part de la instituci\u00f3 CERCA de la Generalitat de Catalunya. L&#8217;any 2009 es va convertir en un dels cinc primers centres d\u2019investigaci\u00f3 espanyols acreditats com a institut d\u2019investigaci\u00f3 sanit\u00e0ria per l\u2019Instituto de Salud Carlos III. A m\u00e9s, forma part del programa \u201cHR Excellence in Research\u201d de la Uni\u00f3 Europea i \u00e9s membre de EATRIS i REGIC. Des de l\u2019any 2018, l\u2019IDIBELL \u00e9s un Centro Acreditado de la Fundaci\u00f3n Cient\u00edfica AECC (FCAECC).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Est\u00e0 comprovat que la infecci\u00f3 per SARS-CoV-2 es manifesta de formes molt diferents: alguns casos simplement mostren un malestar lleu durant pocs dies, altres han d\u2019ingressar a la UCI i d\u2019altres fins i tot la passen sense experimentar cap mena de s\u00edmptoma. Tamb\u00e9 hi ha casos, per\u00f2, que tot i haver estat convisquent amb persones [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":20322,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[380,340,457],"tags":[],"class_list":["post-20321","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-malalties-neurometaboliques","category-neurociencies","category-p-de-neurociencies"],"publishpress_future_action":{"enabled":false,"date":"2025-01-02 20:34:31","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/20321","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=20321"}],"version-history":[{"count":3,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/20321\/revisions"}],"predecessor-version":[{"id":20335,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/20321\/revisions\/20335"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/20322"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=20321"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=20321"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=20321"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}