El c\u00e0ncer de pr\u00f2stata \u00e9s el c\u00e0ncer m\u00e9s prevalent en homes arreu del m\u00f3n, i de fet va representar la cinquena causa de mort per c\u00e0ncer en homes l\u2019any 2020. Prop d\u2019un 70% dels pacients amb c\u00e0ncer de pr\u00f2stata en estadis avan\u00e7ats, les c\u00e8l\u00b7lules canceroses es desplacen fins el torrent sanguini i arriben a instal\u00b7lar-se als ossos. Aquest fenomen es coneix com a met\u00e0stasi \u00f2ssia i dona lloc a complicacions que perjudiquen greument la qualitat de vida del pacient, a m\u00e9s de reduir dr\u00e0sticament les probabilitats de superviv\u00e8ncia.<\/p>\n
Un grup d\u2019investigadors de l\u2019Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL<\/a>), de la Universitat de Barcelona (UB) i Vall d\u2019Hebr\u00f3n Recerca ha fet un estudi per identificar quines mol\u00e8cules podrien afavorir la met\u00e0stasi \u00f2ssia en el c\u00e0ncer de pr\u00f2stata<\/strong>. Tal com expliquen al seu treball, publicat a la revista Cancers<\/em><\/a>, han observat que les c\u00e8l\u00b7lules tumorals amb una baixa expressi\u00f3 d\u2019una mol\u00e8cula concreta, el microRNA miR-135b<\/em><\/strong>, tenen m\u00e9s capacitat per a establir met\u00e0stasi \u00f2ssia. \u00c9s a dir, una de les funcions de miR-135b<\/em> seria evitar aquesta complicaci\u00f3 en els estadis m\u00e9s avan\u00e7ats de la malaltia. Els resultats han estat possibles gr\u00e0cies a l\u2019estudi de mostres de pacients del Servei d\u2019Urologia de l\u2019Hospital Universitari Vall Hebron.<\/p>\n Els microRNAs s\u00f3n petites mol\u00e8cules que regulen l\u2019expressi\u00f3 de gens concrets i, per tant, el funcionament de la c\u00e8l\u00b7lula. \u201cAlguns microRNAs poden promoure el creixement del tumor i d\u2019altres el poden restringir, per tant, si arribem a con\u00e8ixer b\u00e9 com funcionen, podrien representar eines molt valuoses per controlar i tractar aquesta malaltia\u201d<\/em>, expliquen les \u00a0Dres. Ruth Rodr\u00edguez-Barrueco i Anna Santamaria, <\/strong>coordinadores d\u2019aquest treball i investigadores de l\u2019IDIBELL i del Vall d\u2019Hebron Recerca, respectivament.<\/p>\n La Dra. Mireia Olivan<\/strong>, ara investigadora de l\u2019IDIBELL i la UB i primera autora de l\u2019estudi, afegeix que \u201canalitzar els nivells del miR-135b en els casos de c\u00e0ncer de pr\u00f2stata podria ser, doncs, un indicador del pron\u00f2stic d\u2019aquesta malaltia, a m\u00e9s de ser \u00fatil a l\u2019hora de dissenyar nous tractaments\u201d<\/em>.<\/p>\n <\/p>\n <\/p>\n L\u2019Institut d’Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) \u00e9s un centre de recerca en biomedicina creat l\u2019any 2004. Est\u00e0 participat per l’Hospital Universitari de Bellvitge i l\u2019Hospital de Viladecans de l’Institut Catal\u00e0 de la Salut, l’Institut Catal\u00e0 d’Oncologia, la Universitat de Barcelona i l\u2019Ajuntament de l\u2019Hospitalet de Llobregat.<\/em><\/p>\n L\u2019IDIBELL \u00e9s membre del Campus d’Excel\u00b7l\u00e8ncia Internacional de la Universitat de Barcelona HUBc i forma part de la instituci\u00f3 CERCA de la Generalitat de Catalunya. L’any 2009 es va convertir en un dels cinc primers centres d\u2019investigaci\u00f3 espanyols acreditats com a institut d\u2019investigaci\u00f3 sanit\u00e0ria per l\u2019Instituto de Salud Carlos III. A m\u00e9s, forma part del programa \u201cHR Excellence in Research\u201d de la Uni\u00f3 Europea i \u00e9s membre de EATRIS i REGIC. Des de l\u2019any 2018, l\u2019IDIBELL \u00e9s un Centro Acreditado de la Fundaci\u00f3n Cient\u00edfica AECC (FCAECC).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":" Un grup d\u2019investigadors de l\u2019IDIBELL, la UB i Vall d\u2019Hebr\u00f3n Recerca han identificat una mol\u00e8cula implicada en la met\u00e0stasi \u00f2ssia associada al c\u00e0ncer de pr\u00f2stata i que podria ser \u00fatil en el disseny de noves ter\u00e0pies per al seu tractament.<\/p>\n","protected":false},"author":8,"featured_media":20315,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[332,365,447],"tags":[],"class_list":["post-20314","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cancer","category-cancer-ginecologic","category-p-de-mecanismes-molelculars-i-terapia-experimental-en-oncologia-oncobell"],"publishpress_future_action":{"enabled":false,"date":"2024-11-28 21:57:38","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/20314","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=20314"}],"version-history":[{"count":1,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/20314\/revisions"}],"predecessor-version":[{"id":20316,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/20314\/revisions\/20316"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/20315"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=20314"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=20314"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=20314"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}