{"id":20048,"date":"2021-12-29T10:30:23","date_gmt":"2021-12-29T09:30:23","guid":{"rendered":"https:\/\/idibell.cat\/?p=20048"},"modified":"2021-12-23T15:34:13","modified_gmt":"2021-12-23T14:34:13","slug":"sobren-noves-vies-en-el-tractament-de-la-fibrosi-quistica","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2021\/12\/sobren-noves-vies-en-el-tractament-de-la-fibrosi-quistica\/","title":{"rendered":"S\u2019obren noves vies en el tractament de la fibrosi qu\u00edstica"},"content":{"rendered":"<p><span data-contrast=\"auto\"><strong>La fibrosi qu\u00edstica\u00a0\u00e9s la malaltia heredit\u00e0ria m\u00e9s freq\u00fcent<\/strong> en la poblaci\u00f3 cauc\u00e0sica.\u00a0Aquesta malaltia\u00a0est\u00e0 causada per una mutaci\u00f3 gen\u00e8tica que\u00a0provoca, entre altres,\u00a0afectacions\u00a0en\u00a0les vies a\u00e8ries. Aquestes es deshidraten i produeixen una\u00a0mucositat molt m\u00e9s enganxosa\u00a0que\u00a0atrapa\u00a0els\u00a0pat\u00f2gens\u00a0amb m\u00e9s facilitat,\u00a0donant\u00a0lloc\u00a0a\u00a0<strong>infeccions\u00a0i inflamacions\u00a0recurrents<\/strong>, el que acaba sent\u00a0un problema\u00a0cr\u00f2nic en\u00a0persones\u00a0amb fibrosi qu\u00edstica.<\/span><\/p>\n<p><span data-contrast=\"auto\">El efectes sobre les <strong>vies respirat\u00f2ries<\/strong>\u00a0indueixen\u00a0un\u00a0increment\u00a0de\u00a0les\u00a0esp\u00e8cies reactives d\u2019oxigen, mol\u00e8cules\u00a0inestables que ataquen el que tenen al voltant i provoquen<strong>\u00a0estr\u00e8s oxidatiu.<\/strong>\u00a0L\u2019estr\u00e8s oxidatiu\u00a0degrada\u00a0les c\u00e8l\u00b7lules i els\u00a0teixits\u00a0i minva l\u2019efic\u00e0cia de les\u00a0defenses enfront agressions externes, tot\u00a0afavorint\u00a0les infeccions i la inflamaci\u00f3 esmentades.\u00a0Per aix\u00f2,\u00a0les c\u00e8l\u00b7lules\u00a0activen una resposta de protecci\u00f3\u00a0molt complexa\u00a0regulada a nivell gen\u00e8tic.<\/span><\/p>\n<p><span data-contrast=\"auto\">Un estudi del grup de recerca en\u00a0<\/span><a href=\"https:\/\/idibell.cat\/recerca\/area-de-medicina-translacional\/programa-de-gens-malaltia-i-terapia\/processos-immune-inflamatoris-i-terapia-genica\/\"><span data-contrast=\"none\">Processos\u00a0Immunoinflamatoris\u00a0i Ter\u00e0pia G\u00e8nica<\/span><\/a><span data-contrast=\"auto\">\u00a0de l\u2019IDIBELL amb el suport de la Unitat de Bioinform\u00e0tica\u00a0ha\u00a0fet un\u00a0an\u00e0lisi\u00a0amb l\u2019objectiu de trobar nous gens i\u00a0reguladors\u00a0relacionats\u00a0amb\u00a0la resposta a\u00a0l\u2019estr\u00e8s oxidatiu.\u00a0S\u2019han identificat diversos\u00a0gens i reguladors\u00a0que\u00a0hi\u00a0tenen un paper important i, per tant,\u00a0serien\u00a0possibles\u00a0candidats\u00a0a l\u2019hora de <strong>dissenyar noves ter\u00e0pies<\/strong>.\u00a0A m\u00e9s,\u00a0en la mateixa investigaci\u00f3 tamb\u00e9 han\u00a0buscat <strong>f\u00e0rmacs\u00a0ja comercialitzats\u00a0que\u00a0puguin\u00a0ajudar\u00a0<\/strong>a\u00a0combatre l\u2019estr\u00e8s oxidatiu\u00a0mitjan\u00e7ant els gens identificats anteriorment.\u00a0Aquest treball ha rebut finan\u00e7ament de l\u2019<\/span><a href=\"https:\/\/fibrosiquistica.org\/ca\/\"><span data-contrast=\"none\">Associaci\u00f3 Catalana de Fibrosi Qu\u00edstica<\/span><\/a><span data-contrast=\"auto\">\u00a0(ACFQ).<\/span><\/p>\n<p><i><span data-contrast=\"auto\">\u201cAquests\u00a0f\u00e0rmacs, sols o combinats amb els tractaments actuals, podrien beneficiar als pacients amb fibrosi qu\u00edstica tot\u00a0prevenint\u00a0la degradaci\u00f3 accelerada dels pulmons, que \u00e9s un dels pitjors efectes de la malaltia\u201d<\/span><\/i><span data-contrast=\"auto\">\u00a0explica el\u00a0<\/span><b><span data-contrast=\"auto\">Dr. Josep Maria Aran<\/span><\/b><span data-contrast=\"auto\">, qui ha liderat aquest treball, \u201c<\/span><i><span data-contrast=\"auto\">per\u00f2\u00a0aix\u00f2 s\u00f3n resultats preliminars\u00a0i\u00a0per portar-los a la pr\u00e0ctica cal fer\u00a0m\u00e9s\u00a0experiments\u00a0controlats\u00a0i\u00a0assajos cl\u00ednics\u201d .<\/span><\/i><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><em>L\u2019Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) \u00e9s un centre de recerca en biomedicina creat l\u2019any 2004. Est\u00e0 participat per l\u2019Hospital Universitari de Bellvitge i l\u2019Hospital de Viladecans de l\u2019Institut Catal\u00e0 de la Salut, l\u2019Institut Catal\u00e0 d\u2019Oncologia, la Universitat de Barcelona i l\u2019Ajuntament de l\u2019Hospitalet de Llobregat.<\/em><\/p>\n<p><em>L\u2019IDIBELL \u00e9s membre del Campus d\u2019Excel\u00b7l\u00e8ncia Internacional de la Universitat de Barcelona HUBc i forma part de la instituci\u00f3 CERCA de la Generalitat de Catalunya. L\u2019any 2009 es va convertir en un dels cinc primers centres d\u2019investigaci\u00f3 espanyols acreditats com a institut d\u2019investigaci\u00f3 sanit\u00e0ria per l\u2019Instituto de Salud Carlos III. A m\u00e9s, forma part del programa \u201cHR Excellence in Research\u201d de la Uni\u00f3 Europea i \u00e9s membre de EATRIS i REGIC. Des de l\u2019any 2018, l\u2019IDIBELL \u00e9s un Centro Acreditado de la Fundaci\u00f3n Cient\u00edfica AECC (FCAECC).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un grup d\u2019investigaci\u00f3 de l\u2019IDIBELL ha\u00a0identificat gens relacionats amb la resposta a l\u2019estr\u00e8s oxidatiu que podrien\u00a0ajudar a dissenyar nous\u00a0tractament\u00a0per\u00a0la fibrosi qu\u00edstica.<\/p>\n","protected":false},"author":8,"featured_media":20098,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[334,464,378],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-09 06:08:55","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/20048"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=20048"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/20048\/revisions"}],"predecessor-version":[{"id":20074,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/20048\/revisions\/20074"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/20098"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=20048"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=20048"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=20048"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}