{"id":20044,"date":"2021-12-21T09:03:54","date_gmt":"2021-12-21T08:03:54","guid":{"rendered":"https:\/\/idibell.cat\/?p=20044"},"modified":"2021-12-21T09:04:37","modified_gmt":"2021-12-21T08:04:37","slug":"identificats-dos-gens-implicats-en-les-afectacions-cerebrals-dels-nens-i-nenes-amb-simptomes-obsessiu-compulsiu","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2021\/12\/identificats-dos-gens-implicats-en-les-afectacions-cerebrals-dels-nens-i-nenes-amb-simptomes-obsessiu-compulsiu\/","title":{"rendered":"Identificats dos gens implicats en les afectacions cerebrals dels nens i nenes amb s\u00edmptomes obsessiu-compulsiu"},"content":{"rendered":"<p>El trastorn obsessiu compulsiu (TOC) es caracteritza per l&#8217;aparici\u00f3 de pensaments o impulsos intrusius que acaben desembocant en comportaments repetitius. Es tracta d&#8217;un trastorn que pateix entre l&#8217;1 i el 3% de la poblaci\u00f3, la majoria dels quals s\u00f3n pacients cr\u00f2nics. Tot i aix\u00f2, l&#8217;impacte d&#8217;aquesta malaltia es pot minimitzar molt amb la prevenci\u00f3 i la detecci\u00f3 preco\u00e7.<\/p>\n<p>Un <a href=\"https:\/\/idibell.cat\/recerca\/area-de-neurociencies\/programa-de-neurociencies\/psiquiatria-i-salut-mental\/\">equip de recerca<\/a> del programa de neuroci\u00e8ncies de l&#8217;IDIBELL i de l&#8217;Hospital Universitari de Bellvitge, liderat pel Dr. Carles Soriano-Mas, tamb\u00e9 membre del CIBER de Salut Mental (CIBERSAM), ha identificat <strong>dos gens associats amb el comportament anormalment reverberant dels circuits cerebrals implicats al TOC<\/strong>. L&#8217;activaci\u00f3 reiterada d&#8217;aquests circuits impedeix que el pacient pugui passar de manera fluida d&#8217;una tasca a la seg\u00fcent, cosa que s&#8217;acaba traduint en el comportament repetitiu caracter\u00edstic.<\/p>\n<p><em>\u201cAquests resultats suposen un pas endavant en la identificaci\u00f3 de possibles dianes terap\u00e8utiques i el desenvolupament de nous tractaments farmacol\u00f2gics\u201d<\/em>, explica el <strong>Dr. Soriano-Mas<\/strong>. Aix\u00ed mateix, els gens identificats estan relacionats amb l&#8217;anomenada neurotransmissi\u00f3 glutamat\u00e8rgica, per tant, tal com indica el doctor, una de les vies terap\u00e8utiques que cal abordar seria aquest tipus de connexi\u00f3 neuronal.<\/p>\n<p>L&#8217;aparici\u00f3 de <strong>s\u00edmptomes obsessivocompulsius durant la inf\u00e0ncia<\/strong> es considera un factor de risc per desenvolupar TOC a l&#8217;edat adulta. Es creu que l&#8217;aparici\u00f3 d&#8217;aquests s\u00edmptomes primerencs ja \u00e9s indicativa d&#8217;una possible alteraci\u00f3 en els circuits cerebrals implicats al TOC. <em>\u201cD&#8217;aqu\u00ed la import\u00e0ncia de la detecci\u00f3 preco\u00e7<\/em> \u2013indica <strong>Dr. Maria Su\u00f1ol<\/strong>, primera autora del treball\u2013, <em>si identifiquem a temps els primers s\u00edmptomes i les seves causes podr\u00edem ser capa\u00e7os d\u2019aturar-ho abans que es cronifiquin les possibles alteracions cerebrals\u201d.<\/em><\/p>\n<p>&nbsp;<\/p>\n<h3>Combinant resson\u00e0ncies magn\u00e8tiques cerebrals amb an\u00e0lisi gen\u00e8tic<\/h3>\n<p>Per a aquest <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2667174321001543?via%3Dihub\">projecte<\/a> es van estudiar m\u00e9s de <strong>220 nens i nenes<\/strong> sense un diagn\u00f2stic de trastorn obsessiu compulsiu per\u00f2 que en mostraven s\u00edmptomes a diferents nivells, amb l\u2019objectiu d\u2019evitar que la medicaci\u00f3 o altres comorbiditats afectessin el resultat.<\/p>\n<p>A aquests nens i nenes se&#8217;ls va realitzar una resson\u00e0ncia magn\u00e8tica del cervell per avaluar-ne la funcionalitat i l&#8217;afectaci\u00f3 dels circuits neuronals implicats al TOC. Paral\u00b7lelament, se&#8217;ls va practicar una an\u00e0lisi de sang per avaluar-ne els gens i, a trav\u00e9s d&#8217;assajos bioinform\u00e0tics posteriors, es varen determinar aquells que podrien estar modulant l&#8217;activaci\u00f3 reverberant dels circuits neuronals.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><em>L\u2019Institut d&#8217;Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) \u00e9s un centre de recerca en biomedicina creat l\u2019any 2004. Est\u00e0 participat per l&#8217;Hospital Universitari de Bellvitge i l\u2019Hospital de Viladecans de l&#8217;Institut Catal\u00e0 de la Salut, l&#8217;Institut Catal\u00e0 d&#8217;Oncologia, la Universitat de Barcelona i l\u2019Ajuntament de l\u2019Hospitalet de Llobregat.<\/em><\/p>\n<p><em>L\u2019IDIBELL \u00e9s membre del Campus d&#8217;Excel\u00b7l\u00e8ncia Internacional de la Universitat de Barcelona HUBc i forma part de la instituci\u00f3 CERCA de la Generalitat de Catalunya. L&#8217;any 2009 es va convertir en un dels cinc primers centres d\u2019investigaci\u00f3 espanyols acreditats com a institut d\u2019investigaci\u00f3 sanit\u00e0ria per l\u2019Instituto de Salud Carlos III. A m\u00e9s, forma part del programa \u201cHR Excellence in Research\u201d de la Uni\u00f3 Europea i \u00e9s membre de EATRIS i REGIC. Des de l\u2019any 2018, l\u2019IDIBELL \u00e9s un Centro Acreditado de la Fundaci\u00f3n Cient\u00edfica AECC (FCAECC).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un equip de l&#8217;IDIBELL, l&#8217;Hospital Universitari de Bellvitge i CIBERSAM, en col\u00b7laboraci\u00f3 amb ISGlobal i Harvard Medical School, ha descrit alteracions en dos gens que explicaria el comportament anormalment reverberant dels circuits cerebrals implicats al TOC.<\/p>\n","protected":false},"author":8,"featured_media":20045,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[340,457,429],"tags":[],"class_list":["post-20044","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-neurociencies","category-p-de-neurociencies","category-psiquiatria-i-salut-mental"],"publishpress_future_action":{"enabled":false,"date":"2025-01-25 10:25:07","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/20044","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=20044"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/20044\/revisions"}],"predecessor-version":[{"id":20047,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/20044\/revisions\/20047"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/20045"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=20044"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=20044"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=20044"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}