{"id":19999,"date":"2021-12-15T09:28:29","date_gmt":"2021-12-15T08:28:29","guid":{"rendered":"https:\/\/idibell.cat\/?p=19999"},"modified":"2021-12-15T09:30:10","modified_gmt":"2021-12-15T08:30:10","slug":"nova-tecnica-diagnostica-per-a-la-deteccio-de-vph-en-cancers-dorofaringe","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2021\/12\/nova-tecnica-diagnostica-per-a-la-deteccio-de-vph-en-cancers-dorofaringe\/","title":{"rendered":"Nova t\u00e8cnica diagn\u00f2stica per a la detecci\u00f3 de VPH en c\u00e0ncers d’orofaringe"},"content":{"rendered":"

Al m\u00f3n es diagnostiquen cada any al voltant de 42.000 nous casos de c\u00e0ncers d’orofaringe causats per la infecci\u00f3 del virus del papil\u00b7loma hum\u00e0 (VPH).<\/p>\n

Determinar si es tracta o no d’un c\u00e0ncer relacionat amb el VPH \u00e9s vital per definir la millor estrat\u00e8gia terap\u00e8utica, ja que d’aix\u00f2 en dependr\u00e0 la resposta al tractament i l’evoluci\u00f3 diferencial de la malaltia.<\/p>\n

Les guies cl\u00edniques recomanen realitzar una doble prova per definir si un tumor \u00e9s causat pel virus o no. Es recomana la detecci\u00f3 de p16, una prote\u00efna indicadora de tumorogenesi causada pel virus, juntament amb la detecci\u00f3 directa de l\u2019ADN del virus i el seu genotipatge.<\/p>\n

El grup de recerca d’Infeccions i C\u00e0ncer<\/a> de l’Institut d’Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) i de l’Institut Catal\u00e0 d’Oncologia (ICO), en col\u00b7laboraci\u00f3 amb la companyia diagn\u00f2stica Atila Biosystems, ha avaluat la capacitat d’un nou m\u00e8tode de detecci\u00f3 del VPH, l\u2019assaig AmpFire HPV. Aquest nou assaig permet la detecci\u00f3 de fins a 15 genotips de VPH de manera molt m\u00e9s senzilla i r\u00e0pida que les t\u00e8cniques moleculars utilitzades fins al moment.<\/p>\n

En l’estudi publicat a The Journal of Molecular Diagnostics<\/em> <\/a>els i les investigadores han analitzat fins a 160 mostres de tumors d’orofaringe. \u00a0L\u2019assaig de Linear Array, un dels assajos de PCR m\u00e9s utilitzats en la pr\u00e0ctica cl\u00ednica per a la detecci\u00f3 de VPH, s\u2019ha comparat amb el nou assaig AmpFire HPV. Els resultats obtinguts han determinat que les dues t\u00e8cniques tenen la mateixa sensibilitat de detecci\u00f3 i s\u00f3n capaces de distingir les mateixes variants del VPH.<\/p>\n

Amb aquests resultats, el Dr. Miguel \u00c1ngel Pav\u00f3n, l\u00edder del projecte, conclou: “Aquesta nova t\u00e8cnica, amb la mateixa sensibilitat i especificitat que les t\u00e8cniques utilitzades fins ara, ens permetr\u00e0 diagnosticar els tumors d\u2019orofaringe causats pel VPH<\/em> d\u2019una manera m\u00e9s senzilla<\/em> i f\u00e0cil d\u2019implementar a la pr\u00e0ctica cl\u00ednica<\/em>“.<\/p>\n

 <\/p>\n

 <\/p>\n

L\u2019Institut d’Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) \u00e9s un centre de recerca en biomedicina creat l\u2019any 2004. Est\u00e0 participat per l’Hospital Universitari de Bellvitge i l\u2019Hospital de Viladecans de l’Institut Catal\u00e0 de la Salut, l’Institut Catal\u00e0 d’Oncologia, la Universitat de Barcelona i l\u2019Ajuntament de l\u2019Hospitalet de Llobregat.<\/em><\/p>\n

L\u2019IDIBELL \u00e9s membre del Campus d’Excel\u00b7l\u00e8ncia Internacional de la Universitat de Barcelona HUBc i forma part de la instituci\u00f3 CERCA de la Generalitat de Catalunya. L’any 2009 es va convertir en un dels cinc primers centres d\u2019investigaci\u00f3 espanyols acreditats com a institut d\u2019investigaci\u00f3 sanit\u00e0ria per l\u2019Instituto de Salud Carlos III. A m\u00e9s, forma part del programa \u201cHR Excellence in Research\u201d de la Uni\u00f3 Europea i \u00e9s membre de EATRIS i REGIC. Des de l\u2019any 2018, l\u2019IDIBELL \u00e9s un Centro Acreditado de la Fundaci\u00f3n Cient\u00edfica AECC (FCAECC).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

El nou assaig permet la detecci\u00f3 i genotipatge del virus del papil\u00b7loma hum\u00e0 (VPH) amb la mateixa sensibilitat d\u2019altres PCRs d\u2019\u00fas habitual per\u00f2 seguint un procediment molt m\u00e9s senzill.<\/p>\n","protected":false},"author":8,"featured_media":20000,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[332,337,454],"tags":[],"class_list":["post-19999","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cancer","category-infeccions-i-cancer","category-p-depidemiologia-salut-publica-prevencio-del-cancer-i-cures-palliatives"],"publishpress_future_action":{"enabled":false,"date":"2024-12-25 23:46:57","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/19999","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=19999"}],"version-history":[{"count":1,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/19999\/revisions"}],"predecessor-version":[{"id":20001,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/19999\/revisions\/20001"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/20000"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=19999"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=19999"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=19999"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}