{"id":19957,"date":"2021-12-10T12:00:45","date_gmt":"2021-12-10T11:00:45","guid":{"rendered":"https:\/\/idibell.cat\/?p=19957"},"modified":"2021-12-10T10:20:27","modified_gmt":"2021-12-10T09:20:27","slug":"descobreixen-un-mecanisme-essencial-pel-manteniment-de-la-densitat-ossia","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2021\/12\/descobreixen-un-mecanisme-essencial-pel-manteniment-de-la-densitat-ossia\/","title":{"rendered":"Descobreixen un mecanisme essencial pel manteniment de la densitat \u00f2ssia"},"content":{"rendered":"<p>A part de materials com calci, f\u00f2sfor o col\u00b7l\u00e0gen, els ossos tamb\u00e9 contenen c\u00e8l\u00b7lules de tres tipus: osteoblasts, osteoclasts i oste\u00f2cits. Actualment, sabem que els oste\u00f2cits actuen com a directors d\u00b4orquestra, comunicant-se amb osteoblasts i osteoclasts per coordinar la remodelaci\u00f3 \u00f2ssia, necess\u00e0ria per adaptar-se a les exig\u00e8ncies fisiol\u00f2giques de l\u2019organisme. Els osteoblasts fabriquen teixit ossi i els osteoclasts el reabsorbeixen i remodelen. <strong>Per tal que es mantingui la integritat dels ossos, cal un equilibri entre l\u2019activitat dels tres tipus de c\u00e8l\u00b7lules<\/strong>.<\/p>\n<p>En les malalties osteop\u00e8niques un desequilibri en l\u2019activitat d\u2019aquestes tres c\u00e8l\u00b7lules porta a la p\u00e8rdua de la massa \u00f2ssia. Aquestes malalties tenen causes diverses, relacionades amb la edat, estat hormonal, la gen\u00e8tica o l\u00b4estat nutricional, entre d\u2019altres, i encara no s\u2019ha trobat una cura definitiva que ajudi a recuperar la massa \u00f2ssia perduda<\/p>\n<p>&nbsp;<\/p>\n<h4>El paper de NRF2<\/h4>\n<p>Fins ara, s\u2019havia vist que NRF2, una prote\u00efna que regula l\u2019expressi\u00f3 de gens en resposta a radicals d\u00b4oxigen, tamb\u00e9 tenia certa import\u00e0ncia en el manteniment dels ossos, per\u00f2 no se n\u2019havia pogut aclarir el mecanisme d\u2019acci\u00f3. Un estudi desenvolupat pel grup de recerca en <a href=\"https:\/\/idibell.cat\/recerca\/area-de-medicina-translacional\/programa-de-diabetis-i-metabolisme\/senyalitzacio-cellular-i-biologia-de-los\/\">Senyalitzaci\u00f3 i Biologia de l\u2019Os<\/a> de l\u2019IDIBELL i la UB<strong> ha desentrellat el rol que t\u00e9 NRF2<\/strong> en els ossos. Aquesta prote\u00efna estimula la generaci\u00f3 i la activitat dels oste\u00f2cits, cosa que afavoreix el manteniment i la integritat dels ossos. De fet, s\u2019ha vist que els ratolins que no tenen NRF2 tenen una menor densitat \u00f2ssia.<\/p>\n<p>Dins d\u2019aquesta mateixa recerca, els investigadors han administrat<strong> dimetil fumarat<\/strong>, un f\u00e0rmac que actualment est\u00e0 aprovat com a tractament de l\u2019esclerosi m\u00faltiple, a ratolines amb osteoporosis. Han vist que aquestes ratolines mantenien millor la massa \u00f2ssia en comparaci\u00f3 a les que no rebien el dimetil fumarat.<\/p>\n<p><em>\u201cAix\u00f2 mostra com un cert nivell de radicals lliures d\u00b4oxigen pot ser benefici\u00f3s per mantenir la integritat de l\u00b4esquelet<\/em> \u2013 comenta <strong>Francesc Ventura<\/strong>, coordinador d\u2019aquest treball <em>\u2013, i obre una nova oportunitat terap\u00e8utica pel disseny de nous f\u00e0rmacs amb acci\u00f3 protectora de la densitat i estructura \u00f2ssia\u201d<\/em>.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><em>L\u2019Institut d&#8217;Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) \u00e9s un centre de recerca en biomedicina creat l\u2019any 2004. Est\u00e0 participat per l&#8217;Hospital Universitari de Bellvitge i l\u2019Hospital de Viladecans de l&#8217;Institut Catal\u00e0 de la Salut, l&#8217;Institut Catal\u00e0 d&#8217;Oncologia, la Universitat de Barcelona i l\u2019Ajuntament de l\u2019Hospitalet de Llobregat.<\/em><\/p>\n<p><em>L\u2019IDIBELL \u00e9s membre del Campus d&#8217;Excel\u00b7l\u00e8ncia Internacional de la Universitat de Barcelona HUBc i forma part de la instituci\u00f3 CERCA de la Generalitat de Catalunya. L&#8217;any 2009 es va convertir en un dels cinc primers centres d\u2019investigaci\u00f3 espanyols acreditats com a institut d\u2019investigaci\u00f3 sanit\u00e0ria per l\u2019Instituto de Salud Carlos III. A m\u00e9s, forma part del programa \u201cHR Excellence in Research\u201d de la Uni\u00f3 Europea i \u00e9s membre de EATRIS i REGIC. Des de l\u2019any 2018, l\u2019IDIBELL \u00e9s un Centro Acreditado de la Fundaci\u00f3n Cient\u00edfica AECC (FCAECC).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un grup de recerca de l\u2019IDIBELL i la UB ha revelat la import\u00e0ncia de la funci\u00f3 que t\u00e9 NRF2, una prote\u00efna que regula l\u2019expressi\u00f3 d\u2019alguns gens en resposta a radicals oxidatius, en el manteniment del teixit ossi.<\/p>\n","protected":false},"author":8,"featured_media":19958,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[334,461,338],"tags":[],"class_list":["post-19957","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicina-translacional","category-p-de-diabetis-i-metabolisme","category-senyalitzacio-cellular-i-biologia-de-l-os"],"publishpress_future_action":{"enabled":false,"date":"2024-12-29 23:45:02","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/19957","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=19957"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/19957\/revisions"}],"predecessor-version":[{"id":19960,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/19957\/revisions\/19960"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/19958"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=19957"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=19957"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=19957"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}