{"id":19310,"date":"2021-10-22T10:43:04","date_gmt":"2021-10-22T08:43:04","guid":{"rendered":"https:\/\/idibell.cat\/?p=19310"},"modified":"2021-10-22T10:43:04","modified_gmt":"2021-10-22T08:43:04","slug":"el-tractament-amb-nanopolimers-preve-la-formacio-dagregats-proteics-en-neurones-derivades-de-pacients-de-parkinson","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2021\/10\/el-tractament-amb-nanopolimers-preve-la-formacio-dagregats-proteics-en-neurones-derivades-de-pacients-de-parkinson\/","title":{"rendered":"El tractament amb nanopol\u00edmers prev\u00e9 la formaci\u00f3 d&#8217;agregats proteics en neurones derivades de pacients de Parkinson"},"content":{"rendered":"<p>El Parkinson \u00e9s una malaltia neurodegenerativa que es caracteritza per la mort de les neurones anomenades dopamin\u00e8rgiques, el que causa les afectacions motores pr\u00f2pies d&#8217;aquest trastorn. La p\u00e8rdua de neurones \u00e9s causada per l&#8217;acumulaci\u00f3 d&#8217;agregats de la prote\u00efna \u03b1-sinucle\u00efna. Aquesta \u00e9s una prote\u00efna present de manera fisiol\u00f2gica en molts tipus neuronals, per\u00f2, <strong>la formaci\u00f3 anormal d&#8217;agregats de \u03b1-sinucle\u00efna afecta la funci\u00f3 neuronal arribant a causar la mort d&#8217;aquestes<\/strong>.<\/p>\n<p>La nanotecnologia ha ajudat a entendre millor i a buscar nous abordatges terap\u00e8utics per a malalties com el Parkinson. Entre ells destaquen els dendr\u00edmers, <strong>pol\u00edmers molt ramificats amb geometries \u00faniques i ben definides<\/strong> que eviten la formaci\u00f3 d&#8217;agregats de \u03b1-sinucle\u00efna i permeten la seva solubilitzaci\u00f3. Aquesta habilitat dels dendr\u00edmers els ha convertit en una prometedora estrat\u00e8gia terap\u00e8utica del Parkinson. De fet, ja han demostrat la seva efic\u00e0cia impedint l&#8217;agregaci\u00f3 de prote\u00efnes <em>in vitro<\/em> i en l\u00ednies cel\u00b7lulars.<\/p>\n<p>Ara, els grups del <strong>Prof. \u00c1ngel Raya<\/strong> i de la <strong>Dra. Antonella Consiglio<\/strong>, dels programes de Medicina Regenerativa i Neuroci\u00e8ncies de l&#8217;IDIBELL, respectivament, en col\u00b7laboraci\u00f3 amb investigadors de la Universitat d&#8217;Alcal\u00e1, han analitzat l&#8217;efectivitat dels dendr\u00edmers en l&#8217;acumulaci\u00f3 end\u00f2gena de \u03b1-sinucle\u00efna en <strong>neurones procedents de pacients de Parkinson<\/strong>. Per a aix\u00f2 han fet servir com a model neurones dopamin\u00e8rgiques diferenciades a partir de c\u00e8l\u00b7lules mare de pacients de Parkinson.<\/p>\n<p>El treball publicat a la revista <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.biomac.1c00884?ref=pdf\"><em>Biomacromolecules<\/em><\/a> demostra que el tractament de les neurones humanes amb dendr\u00edmers evita l&#8217;acumulaci\u00f3 patol\u00f2gica de \u03b1-sinucle\u00efna. &#8220;<em>Els nostres resultats, en un model genu\u00ed de Parkinson, destaquen el potencial terap\u00e8utic dels sistemes dendr\u00edtics, una estrat\u00e8gia eficient i segura que podria posposar o fins i tot aturar la progressi\u00f3 del Parkinson<\/em>&#8221; afirma la <strong>Dra. Raquel Ferrer<\/strong>, investigadora del programa de Medicina Regenerativa de l&#8217;IDIBELL que ha liderat el treball.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><em>L\u2019Institut d&#8217;Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) \u00e9s un centre de recerca en biomedicina creat l\u2019any 2004. Est\u00e0 participat per l&#8217;Hospital Universitari de Bellvitge i l\u2019Hospital de Viladecans de l&#8217;Institut Catal\u00e0 de la Salut, l&#8217;Institut Catal\u00e0 d&#8217;Oncologia, la Universitat de Barcelona i l\u2019Ajuntament de l\u2019Hospitalet de Llobregat.<\/em><\/p>\n<p><em>L\u2019IDIBELL \u00e9s membre del Campus d&#8217;Excel\u00b7l\u00e8ncia Internacional de la Universitat de Barcelona HUBc i forma part de la instituci\u00f3 CERCA de la Generalitat de Catalunya. L&#8217;any 2009 es va convertir en un dels cinc primers centres d\u2019investigaci\u00f3 espanyols acreditats com a institut d\u2019investigaci\u00f3 sanit\u00e0ria per l\u2019Instituto de Salud Carlos III. A m\u00e9s, forma part del programa \u201cHR Excellence in Research\u201d de la Uni\u00f3 Europea i \u00e9s membre de EATRIS i REGIC. Des de l\u2019any 2018, l\u2019IDIBELL \u00e9s un Centro Acreditado de la Fundaci\u00f3n Cient\u00edfica AECC (FCAECC).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un dels segells d&#8217;identitat de la malaltia de Parkinson \u00e9s l&#8217;acumulaci\u00f3 anormal de la prote\u00efna \u03b1-sinucle\u00efna que acaba provocant la mort neuronal causant de les afectacions motores pr\u00f2pies de la malaltia. Els dendr\u00edmers s\u00f3n pol\u00edmers molt ramificats que han demostrat disminuir l&#8217;acumulaci\u00f3 de \u03b1-sinucle\u00efna en neurones dopamin\u00e8rgiques derivades a partir de c\u00e8l\u00b7lules mare de pacients.<\/p>\n","protected":false},"author":8,"featured_media":19311,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[353,349,340,482,457,483],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-07 16:00:06","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/19310"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=19310"}],"version-history":[{"count":1,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/19310\/revisions"}],"predecessor-version":[{"id":19312,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/19310\/revisions\/19312"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/19311"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=19310"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=19310"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=19310"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}