{"id":19252,"date":"2021-10-14T09:22:50","date_gmt":"2021-10-14T07:22:50","guid":{"rendered":"https:\/\/idibell.cat\/?p=19252"},"modified":"2021-10-14T10:24:53","modified_gmt":"2021-10-14T08:24:53","slug":"mir-424503-un-grup-de-micrornas-que-controlen-el-desenvolupament-dun-tipus-de-cancer-de-mama","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2021\/10\/mir-424503-un-grup-de-micrornas-que-controlen-el-desenvolupament-dun-tipus-de-cancer-de-mama\/","title":{"rendered":"miR-424~503, un grup de microRNAs que controlen el desenvolupament d\u2019un tipus de c\u00e0ncer de mama"},"content":{"rendered":"<p>Les <strong>gl\u00e0ndules mam\u00e0ries femenines<\/strong> s\u00f3n \u00f2rgans que canvien constantment. L&#8217;expansi\u00f3 i regressi\u00f3 de l&#8217;epiteli d&#8217;aquestes gl\u00e0ndules ve dictat pels canvis hormonals ov\u00e0rics. Aquests cicles estan altament regulats en l&#8217;espai i el temps, ja que petits desajustos poden donar lloc a conseq\u00fc\u00e8ncies patol\u00f2giques molt greus. En aquest sentit, la <strong>via de senyalitzaci\u00f3 Wnt\/\u03b2-catenina<\/strong> hi juga un paper molt important, es tracta d&#8217;una via que, entre d\u2019altres funcions, regula la proliferaci\u00f3 de l&#8217;epiteli mamari, en conseq\u00fc\u00e8ncia, si es troba anormalment activada pot afavorir el desenvolupament de c\u00e0ncer de mama..<\/p>\n<p>La Dra. Ruth Rodr\u00edguez-Barrueco i el Dr. David Llobet-Nav\u00e0s, de <a href=\"https:\/\/idibell.cat\/recerca\/area-de-cancer\/programa-de-mecanismes-molleculars-i-terapia-experimental-en-oncologia-oncobell\/cancer-ginecologic\/\">l&#8217;equip de recerca en c\u00e0ncer ginecol\u00f2gic de l&#8217;IDIBELL<\/a>, conjuntament amb el Dr. Jose Silva, de l&#8217;Icahn School of Medicine al Mount Sinai (Nova York), i el Dr Jiyang Yu del St. Jude Children&#8217;s Research Hospital (Memphis), han descobert que <strong>els tumors mamaris caracteritzats per una activaci\u00f3 de la via Wnt\/\u03b2-catenina presenten freq\u00fcentment alteracions en un grup de microRNAs<\/strong>.<\/p>\n<p>Estudis previs del mateix equip havien descrit que aquest grup de microRNAs, el cl\u00faster miR-424<em><sup>~<\/sup><\/em>503, actuava com a supressor de tumors en el c\u00e0ncer de mama. Aquest nou estudi publicat a l&#8217;<a href=\"https:\/\/www.embopress.org\/doi\/abs\/10.15252\/embr.202153201\"><strong><em>EMBO Reports<\/em><\/strong><\/a> indica que aquest efecte antitumoral vindria donat, en part, pel seu paper en la regulaci\u00f3 de la via Wnt\/\u03b2-catenina.<\/p>\n<p>\u201c<em>Entendre per qu\u00e8 es generen tumors, els mecanismes moleculars subjacents i el paper que hi juga cadasc\u00fa ens d\u00f3na una perspectiva m\u00e9s \u00e0mplia<\/em> \u2013afirma <strong>Ruth Rodr\u00edguez-Barrueco<\/strong>, investigadora principal de l\u2019IDIBELL i la Universitat de Barcelona-. <em>Una perspectiva que ens permet seguir explorant noves dianes terap\u00e8utiques, que puguem modular, per obtenir tractaments m\u00e9s efica\u00e7os i amb menys efectes secundaris per a les pacients<\/em>\u201d.<\/p>\n<p>Els microRNAs s\u00f3n petits fragments d&#8217;\u00e0cids nucleics que regulen de manera espec\u00edfica l&#8217;expressi\u00f3 de certs gens. &#8220;<em>Nosaltres hem observat que els microRNA miR-424 i miR-503 bloquegen la s\u00edntesi d&#8217;un receptor essencial per a la via de senyalitzaci\u00f3 Wnt\/\u03b2-catenina. Es tracta d&#8217;una estrat\u00e8gia de les c\u00e8l\u00b7lules de l&#8217;epiteli mamari per regular la proliferaci\u00f3 cel\u00b7lular<\/em>&#8221; afirma el <strong>Dr. David Llobet-Nav\u00e0s<\/strong>, tamb\u00e9 investigador principal de l&#8217;IDIBELL i membre del CIBERONC. \u201c<em>Amb aquest estudi nosaltres proposem que quan desapareix aquest grup de microRNAs desapareix el fre de la proliferaci\u00f3 cel\u00b7lular en l\u2019epiteli mamari, i per tant, es pot afavorir el creixement descontrolat i l\u2019aparici\u00f3 eventual de tumors<\/em>\u201d.<\/p>\n<p>Per a aquesta investigaci\u00f3, l&#8217;equip ha utilitzat un <strong>model de ratol\u00ed que no expressa el grup de microRNAs miR-424<\/strong><strong><em><sup>~<\/sup><\/em><\/strong><strong>503<\/strong>. Els investigadors han observat que les femelles que no expressen aquests microRNAs desenvolupen m\u00e9s freq\u00fcentment tumors a la gl\u00e0ndula mam\u00e0ria que es caracteritzen per una sobreactivaci\u00f3 de la via Wnt\/\u03b2-catenina.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><em>L\u2019Institut d&#8217;Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) \u00e9s un centre de recerca en biomedicina creat l\u2019any 2004. Est\u00e0 participat per l&#8217;Hospital Universitari de Bellvitge i l\u2019Hospital de Viladecans de l&#8217;Institut Catal\u00e0 de la Salut, l&#8217;Institut Catal\u00e0 d&#8217;Oncologia, la Universitat de Barcelona i l\u2019Ajuntament de l\u2019Hospitalet de Llobregat.<\/em><\/p>\n<p><em>L\u2019IDIBELL \u00e9s membre del Campus d&#8217;Excel\u00b7l\u00e8ncia Internacional de la Universitat de Barcelona HUBc i forma part de la instituci\u00f3 CERCA de la Generalitat de Catalunya. L&#8217;any 2009 es va convertir en un dels cinc primers centres d\u2019investigaci\u00f3 espanyols acreditats com a institut d\u2019investigaci\u00f3 sanit\u00e0ria per l\u2019Instituto de Salud Carlos III. A m\u00e9s, forma part del programa \u201cHR Excellence in Research\u201d de la Uni\u00f3 Europea i \u00e9s membre de EATRIS i REGIC. Des de l\u2019any 2018, l\u2019IDIBELL \u00e9s un Centro Acreditado de la Fundaci\u00f3n Cient\u00edfica AECC (FCAECC).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Investigadors de l&#8217;IDIBELL i la UB, conjuntament amb el Mount Sinai, han descrit un conjunt de microRNAs que estarien regulant els c\u00e0ncers de mama dependents de la via de senyalitzaci\u00f3 Wnt\/\u03b2-catenina.<\/p>\n","protected":false},"author":8,"featured_media":19254,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1,332,365,447],"tags":[],"class_list":["post-19252","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sin-categorizar","category-cancer","category-cancer-ginecologic","category-p-de-mecanismes-molelculars-i-terapia-experimental-en-oncologia-oncobell"],"publishpress_future_action":{"enabled":false,"date":"2025-01-29 04:41:45","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/19252","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=19252"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/19252\/revisions"}],"predecessor-version":[{"id":19255,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/19252\/revisions\/19255"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/19254"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=19252"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=19252"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=19252"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}