{"id":19229,"date":"2021-10-13T09:00:05","date_gmt":"2021-10-13T07:00:05","guid":{"rendered":"https:\/\/idibell.cat\/?p=19229"},"modified":"2022-01-11T15:09:41","modified_gmt":"2022-01-11T14:09:41","slug":"dues-noves-variants-genetiques-associades-amb-els-intents-de-suicidi-ajuden-a-desentrellar-ne-els-factors-de-risc","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2021\/10\/dues-noves-variants-genetiques-associades-amb-els-intents-de-suicidi-ajuden-a-desentrellar-ne-els-factors-de-risc\/","title":{"rendered":"Dues noves variants gen\u00e8tiques associades amb els intents de su\u00efcidi ajuden a desentrellar-ne els factors de risc"},"content":{"rendered":"<p>El su\u00efcidi s&#8217;ha convertit en un problema de salut p\u00fablica global i ja \u00e9s una de les principals causes de mort, amb gaireb\u00e9 un mili\u00f3 de casos per any a tot el m\u00f3n. <strong>S&#8217;estima que entre un 0,5 i un 5% de la poblaci\u00f3 realitzar\u00e0 un intent de su\u00efcidi al llarg de la seva vida<\/strong>. Entre els factors de risc hi ha principalment alguns \u00a0trastorns psiqui\u00e0trics, com l\u2019esquizofr\u00e8nia, la depressi\u00f3 end\u00f2gena o els trastorns alimentaris, per\u00f2 tamb\u00e9 hi juguen un paper important, les afectacions del son, el tabaquisme o les situacions estressants, tots ells factors que poden estar condicionats per la gen\u00e8tica.<\/p>\n<p>Ara, <strong>l&#8217;an\u00e0lisi del tot el genoma de m\u00e9s mig mili\u00f3 de persones ha identificat dues noves variants gen\u00e8tiques associades amb els intents de su\u00efcidi<\/strong>. Aquestes variants corresponen a un gen codificant per un important receptor del sistema immunitari i estan situades a una regi\u00f3 de la qual encara se&#8217;n desconeix la funci\u00f3. Els resultats s&#8217;han publicat recentment a la revista <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0006322321015705\"><em>Biological Psychiatry<\/em><\/a>.<\/p>\n<p>L&#8217;estudi del Internatinal Suicide Genetics Consortium, en el que hi participen el <strong>Dr. Fernando Fern\u00e1ndez-Aranda<\/strong> i la <strong>Dra. Susana Jimenez-Murcia<\/strong>, investigadors principals de l&#8217;Institut d&#8217;Investigaci\u00f3 Biom\u00e8dica de Bellvitge (<a href=\"https:\/\/idibell.cat\/recerca\/area-de-neurociencies\/programa-de-neurociencies\/psiquiatria-i-salut-mental\/\">IDIBELL<\/a>), caps de la Unitat de Trastorns Alimentaris i de la Unitat d\u2019Addiccions Conductuals de l&#8217;Hospital Universitari de Bellvitge respectivament, membres del CIBEROBN (Red d\u2019Excel\u00b7l\u00e8ncia sobre Obesitat i Nutrici\u00f3 del ISCIII), i professors de la Universitat de Barcelona, mostra que la variant situada en la regi\u00f3 de funci\u00f3 desconeguda contribueix al component gen\u00e8tic del su\u00efcidi, sense estar relacionada amb cap trastorn psiqui\u00e0tric. Aquest estudi tamb\u00e9 ha comptat amb la participaci\u00f3 de l&#8217;Hospital Universitari de la Vall d&#8217;Hebr\u00f3n.<\/p>\n<p>Aquest treball, amb una mostra cinc vegades superior a la dels estudis previs, pret\u00e9n diferenciar les causes gen\u00e8tiques del su\u00efcidi de \u00a0les \u00a0dels trastorns psiqui\u00e0trics i aix\u00ed <strong>caracteritzar les relacions entre el su\u00efcidi, els trastorns psiqui\u00e0trics i altres factors de risc<\/strong>.<\/p>\n<p>El <strong>Dr. Fern\u00e1ndez-Aranda<\/strong> apunta: \u201c<em>\u00c9s molt important tenir en compte que desentrellar el risc gen\u00e8tic actualment no significa poder predir el risc de su\u00efcidi, seria molt prematur. Ens falta encara informaci\u00f3 per poder utilitzar aquests resultats en la pr\u00e0ctica cl\u00ednica, fer-ho, ara per ara, podria ser perill\u00f3s pels pacients<\/em>\u201d.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Gen\u00e8tica compartida i no compartida del \u00a0su\u00efcidi i dels trastorns psiqui\u00e0trics<\/strong><\/p>\n<p>Segons els estudis realitzats fins al moment, es creu que entre el 17% i el 55% del risc de su\u00efcidi tindria una etiologia gen\u00e8tica, i per tant, es podria heretar de pares a fills. Una part d&#8217;aquest percentatge estaria relacionat amb l&#8217;heretabilitat de trastorns psiqui\u00e0trics, per\u00f2 una altra part desconeguda podria estar relacionada amb altres factors de risc encara per determinar, como factors ambientals i trets de personalitat.<\/p>\n<p>La gran mida mostral d&#8217;aquest estudi ha perm\u00e8s <strong>desxifrar que la contribuci\u00f3 gen\u00e8tica dels intents de su\u00efcidi, no relacionada amb els trastorns psiqui\u00e0trics<\/strong>, s\u00ed que est\u00e0 associada\u00a0 a d\u2019altres factors de risc com l&#8217;insomni, el tabaquisme o la propensi\u00f3 a prendre riscos.<\/p>\n<p>\u201c<em>Con\u00e8ixer quins gens estan relacionats, i si aquests gens tamb\u00e9 estan implicats en altres malalties, ens permet anar dibuixant mica en mica el mapa de mecanismes biol\u00f2gics associats als intents de su\u00efcidi. La informaci\u00f3 que extraguem d&#8217;aquest i estudis futurs ens ajudaran a avaluar la seva utilitat cl\u00ednica<\/em>\u201d, conclou el <strong>Dr. Fern\u00e1ndez-Aranda i la Dra. Susana Jimenez-Murcia<\/strong>.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><em>L\u2019Institut d&#8217;Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) \u00e9s un centre de recerca en biomedicina creat l\u2019any 2004. Est\u00e0 participat per l&#8217;Hospital Universitari de Bellvitge i l\u2019Hospital de Viladecans de l&#8217;Institut Catal\u00e0 de la Salut, l&#8217;Institut Catal\u00e0 d&#8217;Oncologia, la Universitat de Barcelona i l\u2019Ajuntament de l\u2019Hospitalet de Llobregat.<\/em><\/p>\n<p><em>L\u2019IDIBELL \u00e9s membre del Campus d&#8217;Excel\u00b7l\u00e8ncia Internacional de la Universitat de Barcelona HUBc i forma part de la instituci\u00f3 CERCA de la Generalitat de Catalunya. L&#8217;any 2009 es va convertir en un dels cinc primers centres d\u2019investigaci\u00f3 espanyols acreditats com a institut d\u2019investigaci\u00f3 sanit\u00e0ria per l\u2019Instituto de Salud Carlos III. A m\u00e9s, forma part del programa \u201cHR Excellence in Research\u201d de la Uni\u00f3 Europea i \u00e9s membre de EATRIS i REGIC. Des de l\u2019any 2018, l\u2019IDIBELL \u00e9s un Centro Acreditado de la Fundaci\u00f3n Cient\u00edfica AECC (FCAECC).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>El su\u00efcidi s&#8217;ha convertit en un problema de salut p\u00fablica global i ja \u00e9s una de les principals causes de mort, amb gaireb\u00e9 un mili\u00f3 de casos per any a tot el m\u00f3n. S&#8217;estima que entre un 0,5 i un 5% de la poblaci\u00f3 realitzar\u00e0 un intent de su\u00efcidi al llarg de la seva vida. [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":19230,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[340,457,515],"tags":[],"class_list":["post-19229","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-neurociencies","category-p-de-neurociencies","category-psiconeurobiologia-dels-trastorns-alimentaris-i-conductes-addictives"],"publishpress_future_action":{"enabled":false,"date":"2024-11-28 22:21:50","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/19229","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=19229"}],"version-history":[{"count":4,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/19229\/revisions"}],"predecessor-version":[{"id":20170,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/19229\/revisions\/20170"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/19230"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=19229"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=19229"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=19229"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}