El trasplantament de fetge \u00e9s l’\u00fanic tractament curatiu per a la insufici\u00e8ncia hep\u00e0tica aguda i la malaltia hep\u00e0tica terminal. At\u00e8s que la seva principal limitaci\u00f3 \u00e9s l’escassetat d’\u00f2rgans disponibles, en les \u00faltimes d\u00e8cades s’ha fet un esfor\u00e7 important per ampliar els criteris per a l’\u00fas d’\u00f2rgans, incloent-hi aquells procedents de donants d’edat avan\u00e7ada o de defuncions per mort card\u00edaca.<\/p>\n
A m\u00e9s, tamb\u00e9 s’han posat en marxa estrat\u00e8gies destinades a millorar la qualitat d’aquests \u00f2rgans i a reduir el risc de mal funcionament despr\u00e9s del trasplantament. No obstant aix\u00f2, a mesura que l’esperan\u00e7a de vida i la prevalen\u00e7a de l’obesitat i la malaltia de fetge gras no alcoh\u00f2lic (HGNA) han augmentat r\u00e0pidament en la poblaci\u00f3 general, tamb\u00e9 s’ha incrementat la incid\u00e8ncia de donants amb fetges esteat\u00f2sics. La relaci\u00f3 entre aquest tipus de donants i els resultats del trasplantament hep\u00e0tic s’ha associat amb una major taxa de disfunci\u00f3 primerenca de l’\u00f2rgan.<\/p>\n
En l’estudi, liderat pel laboratori de Liver Disease de la Dra. Malu Mart\u00ednez Chantar (CIC bioGUNE i CIBER de Malalties Hep\u00e0tiques i Digestives (CIBEREHD), i que ha comptat amb la col\u00b7laboraci\u00f3 del grup de l’IDIBELL liderat per la Dra. Isabel Fabregat<\/strong>, s’ha caracteritzat els efectes del silenciament de la prote\u00efna MCJ en models precl\u00ednics d’isqu\u00e8mia i reperfusi\u00f3 i regeneraci\u00f3 hep\u00e0tica. El treball s’ha centrat en animals compromesos metab\u00f2licament, amb fetge gras i envelliment, tal com passa avui dia a la cl\u00ednica de trasplantament hep\u00e0tic.<\/p>\n En general, el silenciament espec\u00edfic de MCJ a l’hepat\u00f2cit augmenta la producci\u00f3 d’ATP i, per tant, evita el caracter\u00edstic esgotament mitocondrial. D’aquesta manera, es millora el deteriorament de la regeneraci\u00f3 i es redueix la susceptibilitat a la isqu\u00e8mia dels \u00f2rgans “marginals” (fetges esteat\u00f2sics o procedents de donants de edats molt avan\u00e7ades), fent-los aptes per a la cirurgia hep\u00e0tica i el trasplantament de fetge.<\/p>\n “Aquesta mol\u00e8cula obre una finestra terap\u00e8utica per al seu \u00fas en el trasplantament hep\u00e0tic<\/em>“, comenta Naroa Goikoetxea-Usandizaga<\/strong>, investigadora de laboratori Liver Disease en CIC bioGUNE i primer signant d’aquest treball.<\/p>\n En aquest article hi ha participat la Dra. Marta Varela, i s’ha realitzat en col\u00b7laboraci\u00f3 amb el Dr. Jon Mabe (Teknik), Dr. Jordi Gr\u00e0cia (IDIBAPS), Dr. \u00d3scar Lorenzo (Fundaci\u00f3 Jim\u00e9nez D\u00edaz-Universitat Aut\u00f2noma de Madrid), Dra. Paloma Mart\u00edn-Sanz (Institut d’Investigacions Biom\u00e8diques-IIB), Alberto Sols (CSIC-UAM) Dr. Nicola GA Abrescia (CIC bioGUNE), Dra. Guadalupe Sabio (Centre Nacional d’Investigacions Cardiovasculars-CNIC), Dra. Mercedes Rac\u00f3 (University of Vermont), Dr. Juan Anguita (CIC bioGUNE), Dr. Eduardo Mi\u00f1ambres (Marqu\u00e8s de Valdecilla University Hospital-IDIVAL), Dr. C\u00e9sar Mart\u00edn (Universitat del Pa\u00eds Pasco-UPV \/ EHU), Dra. Marina Berenguer (Hospital Universitari i Polit\u00e8cnic La Fe), Dra. Marta Casado (Institut de Biomedicina de Val\u00e8ncia, IBV-CSIC), Dra. Carmen Peralta (Institut d’Investigacions Biom\u00e8diques August Pi i Sunyer-IDIBAPS) i altres investigadors nacionals i internacionals d’aquestes institucions.<\/p>\n <\/p>\n <\/p>\n L\u2019Institut d’Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) \u00e9s un centre de recerca en biomedicina creat l\u2019any 2004. Est\u00e0 participat per l’Hospital Universitari de Bellvitge i l\u2019Hospital de Viladecans de l’Institut Catal\u00e0 de la Salut, l’Institut Catal\u00e0 d’Oncologia, la Universitat de Barcelona i l\u2019Ajuntament de l\u2019Hospitalet de Llobregat.<\/em><\/p>\n L\u2019IDIBELL \u00e9s membre del Campus d’Excel\u00b7l\u00e8ncia Internacional de la Universitat de Barcelona HUBc i forma part de la instituci\u00f3 CERCA de la Generalitat de Catalunya. L’any 2009 es va convertir en un dels cinc primers centres d\u2019investigaci\u00f3 espanyols acreditats com a institut d\u2019investigaci\u00f3 sanit\u00e0ria per l\u2019Instituto de Salud Carlos III. A m\u00e9s, forma part del programa \u201cHR Excellence in Research\u201d de la Uni\u00f3 Europea i \u00e9s membre de EATRIS i REGIC. Des de l\u2019any 2018, l\u2019IDIBELL \u00e9s un Centro Acreditado de la Fundaci\u00f3n Cient\u00edfica AECC (FCAECC).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":" El silenciament de la prote\u00efna MCJ es posiciona com a nova ter\u00e0pia per evitar la fallada hep\u00e0tica despr\u00e9s d’una isqu\u00e8mia-reperfusi\u00f3 en models de s\u00edndrome metab\u00f2lic i envelliment<\/p>\n","protected":false},"author":8,"featured_media":19148,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[332,447,360],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-10 11:00:09","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/19147"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=19147"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/19147\/revisions"}],"predecessor-version":[{"id":19150,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/19147\/revisions\/19150"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/19148"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=19147"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=19147"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=19147"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}