El trasplantament de medul\u00b7la \u00f2ssia pot ser una ter\u00e0pia curativa per a aquells pacients amb malalties hematol\u00f2giques malignes i no malignes. No obstant aix\u00f2, aquest tractament comporta un risc no menyspreable de complicacions potencialment mortals i un impacte directe en la qualitat de vida dels pacients. L’avaluaci\u00f3 pretrasplantament del risc individual \u00e9s essencial per a seleccionar aquells pacients que es podrien beneficiar m\u00e9s del procediment.<\/p>\n
L’endoteli, la monocapa de c\u00e8l\u00b7lules que recobreix l’interior dels vasos sanguinis, juga un paper primordial en la resposta a complicacions infeccioses i no infeccioses dels pacients que reben un trasplantament de medul\u00b7la. Un estudi del grup de recerca en tumors hematopo\u00e8tics i limfoides<\/a> de l’IDIBELL i de l’ICO, publicat a la revista Blood Advances<\/em><\/a>, ha descrit la capacitat d’un indicador d’activaci\u00f3 endotelial, calculat previ al procediment, per predir la probabilitat de trasllat a l’UCI en els pacients receptors d’un trasplantament de progenitors hematopo\u00e8tics. Aquest \u00edndex, anomenat EASIX de les seves sigles en angl\u00e8s Endothelial Activation and Stress Index<\/em><\/strong>, fa servir tres par\u00e0metres disponibles en les an\u00e0lisis de sang de rutina (LDH, creatinina i plaquetes) per calcular el grau d’activaci\u00f3 de l’endoteli.<\/p>\n L’estudi liderat per la Dra. Anna Sureda<\/strong>, cap de grup de l’IDIBELL i cap del servei d’hematologia cl\u00ednica de l’ICO, mostren que els pacients amb un \u00edndex EASIX pretrasplantament elevat, presenten major probabilitat d’ingr\u00e9s a l’UCI que la resta. A m\u00e9s, l’estudi confirma el potencial d’aquest \u00edndex per predir la mortalitat relacionada amb el trasplantament i la superviv\u00e8ncia global en aquests pacients.<\/p>\n Els i les investigadores proposen l’\u00fas de l’\u00edndex EASIX com una eina de pron\u00f2stic per identificar els pacients amb un major risc de patir complicacions greus, i, per tant, necessitar, cures intensives. “La identificaci\u00f3 del risc individual de desenvolupar complicacions greus que requereixin trasllat a l’UCI en pacients receptors d’un trasplantament de progenitors hematopo\u00e8tics podria ajudar-nos a implementar intervencions personalitzades de forma preco\u00e7 i a gestionar recursos sanitaris<\/em>” indica la Dra. Marta Pe\u00f1a<\/strong>, primera autora del treball.<\/p>\n <\/p>\n <\/p>\n L\u2019Institut d’Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) \u00e9s un centre de recerca en biomedicina creat l\u2019any 2004. Est\u00e0 participat per l’Hospital Universitari de Bellvitge i l\u2019Hospital de Viladecans de l’Institut Catal\u00e0 de la Salut, l’Institut Catal\u00e0 d’Oncologia, la Universitat de Barcelona i l\u2019Ajuntament de l\u2019Hospitalet de Llobregat.<\/em><\/p>\n L\u2019IDIBELL \u00e9s membre del Campus d’Excel\u00b7l\u00e8ncia Internacional de la Universitat de Barcelona HUBc i forma part de la instituci\u00f3 CERCA de la Generalitat de Catalunya. L’any 2009 es va convertir en un dels cinc primers centres d\u2019investigaci\u00f3 espanyols acreditats com a institut d\u2019investigaci\u00f3 sanit\u00e0ria per l\u2019Instituto de Salud Carlos III. A m\u00e9s, forma part del programa \u201cHR Excellence in Research\u201d de la Uni\u00f3 Europea i \u00e9s membre de EATRIS i REGIC. Des de l\u2019any 2018, l\u2019IDIBELL \u00e9s un Centro Acreditado de la Fundaci\u00f3n Cient\u00edfica AECC (FCAECC).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":" L’equip d’Hematologia de l’IDIBELL i de l’ICO ha publicat un article a la revista Blood Advances en qu\u00e8 es proposa aquest \u00edndex com una eina capa\u00e7 d’identificar els pacients amb major risc de trasllat a la Unitat de Cures Intensives (UCI) posteriorment al trasplantament de c\u00e8l\u00b7lules progenitores hematopo\u00e8tiques.<\/p>\n","protected":false},"author":8,"featured_media":19121,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[332,447,449],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-11 10:39:58","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/19120"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=19120"}],"version-history":[{"count":1,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/19120\/revisions"}],"predecessor-version":[{"id":19122,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/19120\/revisions\/19122"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/19121"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=19120"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=19120"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=19120"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}